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Associations of Pol...
Associations of Polymorphisms in the Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Gene With Subsequent Coronary Heart Disease : An Individual-Level Meta-Analysis
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- Schillemans, Tessa (författare)
- Karolinska Institutet
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- Tragante, Vinicius (författare)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
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- Maitusong, Buamina (författare)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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visa fler...
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- Gigante, Bruna (författare)
- Karolinska Institutet
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- Cresci, Sharon (författare)
- Washington Univ, Sch Med, John T Milliken Dept Internal Med, Cardiovasc Div, St Louis, MO USA
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- Laguzzi, Federica (författare)
- Karolinska Institutet
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- Vikstrom, Max (författare)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Richards, Mark (författare)
- Univ Otago, Christchurch Heart Inst, Dept Med, Christchurch, New Zealand.;Natl Univ Singapore, Cardiovasc Res Inst, Singapore, Singapore
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- Pilbrow, Anna (författare)
- Univ Otago, Christchurch Heart Inst, Dept Med, Christchurch, New Zealand
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- Cameron, Vicky (författare)
- Univ Otago, Christchurch Heart Inst, Dept Med, Christchurch, New Zealand.
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- Foco, Luisa (författare)
- Eurac Res, Inst Biomed, Bolzano, Italy
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- Doughty, Robert N. (författare)
- Univ Auckland, Heart Hlth Res Grp, Auckland, New Zealand
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- Kuukasjarvi, Pekka (författare)
- Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiothorac Surg, Tampere, Finland
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- Allayee, Hooman (författare)
- Univ Southern Calif, Keck Sch Med, Dept Biochem & Mol Med, Los Angeles, CA USA.;Univ Southern Calif, Keck Sch Med, Dept Populat & Publ Hlth Sci, Los Angeles, CA USA
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- Hartiala, Jaana A. (författare)
- Karolinska Institutet
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- Tang, W. H. Wilson (författare)
- Cleveland Clin Ohio, Lerner Res Inst, Dept Cardiovasc & Metab Sci, Cleveland, OH USA.;Cleveland Clin Ohio, Lerner Res Inst, Ctr Microbiome & Human Hlth, Cleveland, OH USA.;Cleveland Clin Ohio, Dept Cardiovasc Med, Heart Vasc & Thorac Inst, Cleveland, OH USA
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- Lyytikainen, Leo-Pekka (författare)
- Fimlab Labs Ltd, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere, Finland
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- Nikus, Kjell (författare)
- Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiol, Tampere, Finland.;Tampere Univ Hosp, Heart Ctr, Dept Cardiol, Tampere, Finland
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- Laurikka, Jari O. (författare)
- Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiothorac Surg, Tampere, Finland.;Tampere Univ Hosp, Heart Ctr, Dept Thorac Surg, Tampere, Finland
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- Srinivasan, Sundararajan (författare)
- Univ Dundee, Sch Med, Div Populat Hlth & Genom, Dundee, Scotland
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- Mordi, Ify R. (författare)
- Univ Dundee, Sch Med, Div Mol & Clin Med, Dundee, Scotland
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- Trompet, Stella (författare)
- Leiden Univ Med Ctr, Dept Internal Med, Leiden, Netherlands.;Leiden Univ Med Ctr, Sect Gerontol & Geriatr, Leiden, Netherlands.;Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands
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- Kraaijeveld, Adriaan (författare)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
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- van Setten, Jessica (författare)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands
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- Gijsberts, Crystel M. (författare)
- Univ Utrecht, Univ Med Ctr Utrecht, Lab Expt Cardiol, Utrecht, Netherlands.;Radboud Univ Nijmegen, Dept Cardiol, Med Ctr, Nijmegen, Netherlands
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- Maitland-van der Zee, Anke H. (författare)
- Univ Amsterdam, Amsterdam Univ Med Ctr, Dept Resp Med, Amsterdam, Netherlands
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- Saely, Christoph H. (författare)
- Vorarlberg Inst Vasc Invest & Treatment VIVIT, Feldkirch, Austria.;Private Univ Principal Liechtenstein, Triesen, Liechtenstein.;Acad Teaching Hosp Feldkirch, Feldkirch, Austria
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- Gong, Yan (författare)
- Univ Florida, Ctr Pharmacogen & Precis Med, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA
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- Johnson, Julie A. (författare)
- Univ Florida, Ctr Pharmacogen & Precis Med, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA
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- Cooper-DeHoff, Rhonda M. (författare)
- Univ Florida, Ctr Pharmacogen & Precis Med, Dept Pharmacotherapy & Translat Res, Gainesville, FL USA.;Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA
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- Pepine, Carl J. (författare)
- Univ Florida, Coll Med, Div Cardiovasc Med, Gainesville, FL USA
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- Casu, Gavino (författare)
- Azienda Osped Univ, Sassari, Italy
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- Leiherer, Andreas (författare)
- Vorarlberg Inst Vasc Invest & Treatment VIVIT, Feldkirch, Austria.;Private Univ Principal Liechtenstein, Triesen, Liechtenstein
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- Drexel, Heinz (författare)
- Vorarlberg Inst Vasc Invest & Treatment VIVIT, Feldkirch, Austria.;Private Univ Principal Liechtenstein, Triesen, Liechtenstein.;Cty Hosp Bregenz, Dept Med & Intens Care, Bregenz, Austria
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- Horne, Benjamin D. (författare)
- Intermt Med Ctr Heart Inst, Salt Lake City, UT USA.;Stanford Univ, Div Cardiovasc Med, Stanford, CA 94305 USA
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- van der Laan, Sander W. (författare)
- Univ Med Ctr Utrecht, Div Labs Pharm & Biomed Genet, Cent Diagnost Lab, Utrecht, Netherlands
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- Marziliano, Nicola (författare)
- ASST Rhodense Rho Milano, Med Lab Unit, Lombardy, Italy.;Univ Molise, Dept Med & Hlth Sci, Campobasso, Italy
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- Hazen, Stanley L. (författare)
- Cleveland Clin Ohio, Lerner Res Inst, Dept Cardiovasc & Metab Sci, Cleveland, OH USA.;Cleveland Clin Ohio, Lerner Res Inst, Ctr Microbiome & Human Hlth, Cleveland, OH USA.;Cleveland Clin Ohio, Dept Cardiovasc Med, Heart Vasc & Thorac Inst, Cleveland, OH USA
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- Sinisalo, Juha (författare)
- Univ Helsinki, Helsinki Univ Hosp, Heart & Lung Ctr, Helsinki, Finland
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- Kahonen, Mika (författare)
- Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland.;Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany
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- Lehtimaki, Terho (författare)
- Fimlab Labs Ltd, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland
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- Lang, Chim C. (författare)
- Univ Dundee, Sch Med, Div Populat Hlth & Genom, Dundee, Scotland
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- Burkhardt, Ralph (författare)
- Univ Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany.;Univ Leipzig, Life Res Ctr Civilizat Dis, Leipzig, Germany
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- Scholz, Markus (författare)
- Univ Leipzig, LIFE Res Ctr Civilizat Dis, Inst Med Informat Stat & Epidemiol, Leipzig, Germany
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- Jukema, J. Wouter (författare)
- Leiden Univ Med Ctr, Dept Cardiol, Leiden, Netherlands.;Netherlands Heart Inst, Utrecht, Netherlands
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- Eriksson, Niclas, 1978- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Science for Life Laboratory, SciLifeLab,Kardiologi
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- Åkerblom, Axel, 1977- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- James, Stefan, 1964- (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Klinisk fysiologi
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- Held, Claes, 1956- (författare)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi
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- Hagström, Emil (författare)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Spertus, John A. (författare)
- Univ Missouri, St Lukes Mid Amer Heart Inst, Kansas City, MO USA
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- Algra, Ale (författare)
- Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol & Neurosurg, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
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- de Faire, Ulf (författare)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Akesson, Agneta (författare)
- Karolinska Inst, Inst Environm Med, Stockholm, Sweden
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- Asselbergs, Folkert W. (författare)
- Univ Utrecht, Univ Med Ctr Utrecht, Dept Cardiol, Div Heart & Lungs, Utrecht, Netherlands.;UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England.;UCL, Inst Hlth Informat, London, England
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- Patel, Riyaz S. (författare)
- UCL, Fac Populat Hlth Sci, Inst Cardiovasc Sci, London, England.;UCL, Inst Hlth Informat, London, England.;St Bartholomews Hosp, Barts Heart Ctr, London, England
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- Leander, Karin (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-06-23
- 2022
- Engelska.
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Ingår i: Frontiers in Physiology. - : Frontiers Media S.A.. - 1664-042X. ; 13
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Background: The knowledge of factors influencing disease progression in patients with established coronary heart disease (CHD) is still relatively limited. One potential pathway is related to peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PPARGC1A), a transcription factor linked to energy metabolism which may play a role in the heart function. Thus, its associations with subsequent CHD events remain unclear. We aimed to investigate the effect of three different SNPs in the PPARGC1A gene on the risk of subsequent CHD in a population with established CHD.Methods: We employed an individual-level meta-analysis using 23 studies from the GENetIcs of sUbSequent Coronary Heart Disease (GENIUS-CHD) consortium, which included participants (n = 80,900) with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. Three variants in the PPARGC1A gene (rs8192678, G482S; rs7672915, intron 2; and rs3755863, T528T) were tested for their associations with subsequent events during the follow-up using a Cox proportional hazards model adjusted for age and sex. The primary outcome was subsequent CHD death or myocardial infarction (CHD death/myocardial infarction). Stratified analyses of the participant or study characteristics as well as additional analyses for secondary outcomes of specific cardiovascular disease diagnoses and all-cause death were also performed.Results: Meta-analysis revealed no significant association between any of the three variants in the PPARGC1A gene and the primary outcome of CHD death/myocardial infarction among those with established CHD at baseline: rs8192678, hazard ratio (HR): 1.01, 95% confidence interval (CI) 0.98-1.05 and rs7672915, HR: 0.97, 95% CI 0.94-1.00; rs3755863, HR: 1.02, 95% CI 0.99-1.06. Similarly, no significant associations were observed for any of the secondary outcomes. The results from stratified analyses showed null results, except for significant inverse associations between rs7672915 (intron 2) and the primary outcome among 1) individuals aged >= 65, 2) individuals with renal impairment, and 3) antiplatelet users.Conclusion: We found no clear associations between polymorphisms in the PPARGC1A gene and subsequent CHD events in patients with established CHD at baseline.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- polymorphisms
- PPARGC1A
- meta-analysis
- SNPs
- coronary heart disease
- cohort studies
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- ref (ämneskategori)
- art (ämneskategori)
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Gigante, Bruna
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Vikstrom, Max
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Richards, Mark
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Pilbrow, Anna
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Cameron, Vicky
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Foco, Luisa
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Doughty, Robert ...
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Kuukasjarvi, Pek ...
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Allayee, Hooman
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Hartiala, Jaana ...
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Tang, W. H. Wils ...
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Lyytikainen, Leo ...
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Nikus, Kjell
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Laurikka, Jari O ...
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Srinivasan, Sund ...
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Mordi, Ify R.
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Trompet, Stella
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Kraaijeveld, Adr ...
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van Setten, Jess ...
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Gijsberts, Cryst ...
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Maitland-van der ...
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Saely, Christoph ...
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Gong, Yan
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Johnson, Julie A ...
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Cooper-DeHoff, R ...
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Pepine, Carl J.
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Casu, Gavino
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Leiherer, Andrea ...
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Drexel, Heinz
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Horne, Benjamin ...
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van der Laan, Sa ...
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Marziliano, Nico ...
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Hazen, Stanley L ...
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Sinisalo, Juha
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Kahonen, Mika
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Lehtimaki, Terho
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Lang, Chim C.
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Burkhardt, Ralph
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Scholz, Markus
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Jukema, J. Woute ...
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Eriksson, Niclas ...
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Åkerblom, Axel, ...
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James, Stefan, 1 ...
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Held, Claes, 195 ...
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Hagström, Emil
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Spertus, John A.
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Algra, Ale
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de Faire, Ulf
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Akesson, Agneta
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Asselbergs, Folk ...
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Patel, Riyaz S.
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Leander, Karin
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