Sökning: WFRF:(Walker Susan P)
> (2020-2024) >
Associations Betwee...
Associations Between Soluble fms-Like Tyrosine Kinase-1 and Placental Growth Factor and Disease Severity Among Women With Preterm Eclampsia and Preeclampsia
-
- Hastie, Roxanne (författare)
- Uppsala universitet,Klinisk obstetrik,Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia; Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia
-
- Bergman, Lina (författare)
- Uppsala universitet,Klinisk obstetrik,Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa; Univ Gothenburg, Sahlgrenska Acad, Dept Obstet & Gynecol, Inst Clin Sci, Gothenburg, Sweden
-
- Walker, Susan P. (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
-
visa fler...
-
- Kaitu'u-Lino, Tu'uhevaha (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
-
- Hannan, Natalie J. (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
-
- Brownfoot, Fiona (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
-
- Schell, Sonja (författare)
- Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa.
-
- Harper, Alesia (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
-
- Cannon, Ping (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
-
- Cluver, Catherine A. (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.;Stellenbosch Univ, Dept Obstet & Gynaecol, Cape Town, South Africa.
-
- Tong, Stephen (författare)
- Mercy Hosp Women, Mercy Perinatal, Melbourne, Vic, Australia.;Univ Melbourne, Translat Obstet Grp, Dept Obstet & Gynaecol, Heidelberg, Vic, Australia.
-
visa färre...
-
(creator_code:org_t)
- John Wiley & Sons, 2022
- 2022
- Engelska.
-
Ingår i: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 11:16
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- BackgroundThe angiogenic factors soluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF) are postulated to be pathogenic disease drivers of preeclampsia. If true, then circulating levels should become more deranged with increasing disease severity.Methods and ResultsWe investigated the association between circulating sFlt‐1 and PlGF levels and severe adverse maternal outcomes among 348 women with preeclampsia. Compared with 125 women with preeclampsia without severe features, 25 women with preeclampsia and any of hemolysis, elevated liver enzymes, low platelet count syndrome, disseminated intravascular coagulation, or severe renal involvement had sFlt‐1 levels that were 2.63‐fold higher (95% CI, 1.81–3.82), sFlt‐1/PlGF levels that were 10.07‐fold higher (95% CI, 5.36–18.91) and PlGF levels that were 74% lower (adjusted fold change, 0.26 [95% CI, 0.18–0.39]). Compared with 125 women with preeclampsia without severe features, 37 with eclampsia had sFlt‐1 levels that were 2‐fold higher (2.02 [95% CI, 1.32–3.09]), sFlt‐1/PIGF levels that were 4.71‐fold higher (95% CI, 2.30–9.66) and PIGF levels that were 63% lower (0.43‐fold change [95% CI, 0.27–0.68]). Compared with those without severe features, preeclampsia with severe hypertension (n=146) was also associated with altered angiogenic levels (sFlt‐1, 1.71‐fold change [95% CI, 1.39–2.11]; sFlt/PlGF, 2.91 [95% CI, 2.04–4.15]; PlGF, 0.59 [95%CI 0.47–0.74]). We also found that sFlt‐1 and PlGF levels were altered by the number of maternal complications experienced.ConclusionsFurther angiogenic imbalance among women with preeclampsia is likely a pathogenic disease driver responsible for the life‐threatening maternal complications.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- antiangiogenic factors
- eclampsia
- PlGF
- preeclampsia
- severe features
- sFlt-1
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Hastie, Roxanne
-
Bergman, Lina
-
Walker, Susan P.
-
Kaitu'u-Lino, Tu ...
-
Hannan, Natalie ...
-
Brownfoot, Fiona
-
visa fler...
-
Schell, Sonja
-
Harper, Alesia
-
Cannon, Ping
-
Cluver, Catherin ...
-
Tong, Stephen
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Reproduktionsmed ...
- Artiklar i publikationen
-
Journal of the A ...
- Av lärosätet
-
Uppsala universitet