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RNA sequencing-based single sample predictors of molecular subtype and risk of recurrence for clinical assessment of early-stage breast cancer
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- Staaf, Johan (author)
- Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Häkkinen, Jari (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Hegardt, Cecilia (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Saal, Lao H (author)
- Lund University,Lunds universitet,Translational Oncogenomics,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Kimbung, Siker (author)
- Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Hedenfalk, Ingrid (author)
- Lund University,Lunds universitet,Bröst- och ovarialcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast and Ovarian Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Lien, Tonje (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, POB 4953 Nydalen, N-0424 Oslo, Norway.;Oslo Univ Hosp, Dept Pathol, POB 4953 Nydalen, N-0424 Oslo, Norway.,Oslo university hospital
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- Sørlie, Therese (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, POB 4953 Nydalen, N-0424 Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.,Oslo university hospital
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- Naume, Bjørn (author)
- Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Dept Oncol, Div Canc Med, POB 4953 Nydalen, N-0424 Oslo, Norway.,Oslo university hospital
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- Russnes, Hege (author)
- Oslo Univ Hosp, Inst Canc Res, Dept Canc Genet, POB 4953 Nydalen, N-0424 Oslo, Norway.;Oslo Univ Hosp, Dept Pathol, POB 4953 Nydalen, N-0424 Oslo, Norway.,Oslo university hospital
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- Marcone, Rachel (author)
- Ecole Polytech Fed Lausanne, Sch Life Sci, ISREC Swiss Inst Expt Canc Res, CH-1015 Lausanne, Switzerland.;Ecole Polytech Fed Lausanne, Sch Life Sci, Swiss Inst Bioinformat, CH-1005 Lausanne, Switzerland.,Swiss Institute for Experimental Cancer Research (ISREC)
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- Ayyanan, Ayyakkannu (author)
- Ecole Polytech Fed Lausanne, Sch Life Sci, ISREC Swiss Inst Expt Canc Res, CH-1015 Lausanne, Switzerland.,Swiss Institute for Experimental Cancer Research (ISREC)
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- Brisken, Cathrin (author)
- Ecole Polytech Fed Lausanne, Sch Life Sci, ISREC Swiss Inst Expt Canc Res, CH-1015 Lausanne, Switzerland.,Swiss Institute for Experimental Cancer Research (ISREC)
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- Malterling, Rebecka R. (author)
- Reg Jönköping Cty, Dept Surg, Jönköping, Sweden.,Region Jönköping County
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- Asking, Bengt (author)
- Reg Jönköping Cty, Dept Surg, Jönköping, Sweden.,Region Jönköping County
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- Olofsson, Helena (author)
- Uppsala universitet,Klinisk och experimentell patologi,Centrum för klinisk forskning, Västerås,Uppsala University Hospital
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- Lindman, Henrik (author)
- Uppsala universitet,Experimentell och klinisk onkologi,Uppsala University Hospital
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- Bendahl, Pär-Ola (author)
- Lund University,Lunds universitet,Individuell Bröstcancerbehandling,Forskargrupper vid Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Personalized Breast Cancer Treatment,Lund University Research Groups,The Liquid Biopsy and Tumor Progression in Breast Cancer,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Ehinger, Anna (author)
- Lund University,Lunds universitet,Lund Univ, Dept Clin Sci Lund, Div Oncol, SE-22381 Lund, Sweden.;Reg Skane, Lab Med, Dept Genet & Pathol, Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Patologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Pathology, Lund,Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Region Skåne
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- Larsson, Christer (author)
- Lund University,Lunds universitet,Tumörcellsbiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Tumor Cell Biology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Loman, Niklas (author)
- Lund University,Lunds universitet,Lund Univ, Dept Clin Sci Lund, Div Oncol, SE-22381 Lund, Sweden.;Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/ovarialcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/ovarian cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Rydén, Lisa (author)
- Lund University,Lunds universitet,Bröstcancerkirurgi,Forskargrupper vid Lunds universitet,The Liquid Biopsy och Tumörprogression i Bröstcancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast Cancer Surgery,Lund University Research Groups,The Liquid Biopsy and Tumor Progression in Breast Cancer,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital
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- Malmberg, Martin (author)
- Skane Univ Hosp, Dept Hematol Oncol & Radiat Phys, Lund, Sweden.,Skåne University Hospital
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- Borg, Åke (author)
- Lund University,Lunds universitet,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Vallon-Christersson, Johan (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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(creator_code:org_t)
- 2022-08-16
- 2022
- English.
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In: npj Breast Cancer. - : Nature Publishing Group. - 2374-4677. ; 8:1
- Related links:
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Abstract
Subject headings
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- Multigene assays for molecular subtypes and biomarkers can aid management of early invasive breast cancer. Using RNA-sequencing we aimed to develop single-sample predictor (SSP) models for clinical markers, subtypes, and risk of recurrence (ROR). A cohort of 7743 patients was divided into training and test set. We trained SSPs for subtypes and ROR assigned by nearest-centroid (NC) methods and SSPs for biomarkers from histopathology. Classifications were compared with Prosigna in two external cohorts (ABiM, n = 100 and OSLO2-EMIT0, n = 103). Prognostic value was assessed using distant recurrence-free interval. Agreement between SSP and NC for PAM50 {five subtypes) was high (85%, Kappa = 0.78) for Subtype (four subtypes) very high {90%, Kappa = 0.84) and for ROR risk category high (84%, Kappa = 0.75, weighted Kappa = 0.90). Prognostic value was assessed as equivalent and clinically relevant. Agreement with histopathology was very high or high for receptor status, while moderate for Ki67 status and poor for Nottingham histological grade. SSP and Prosigna concordance was high for subtype (OSLO-EMIT0 83%, Kappa = 0.73 and ABiM 80%, Kappa = 0.72) and moderate and high for ROR risk category (68 and 84%, Kappa = 0.50 and 0.70, weighted Kappa = 0.70 and 0.78). Pooled concordance for emulated treatment recommendation dichotomized for chemotherapy was high (85%, Kappa = 0.66). Retrospective evaluation suggested that SSP application could change chemotherapy recommendations for up to 17% of postmenopausal ER+/HER2-/N0 patients with balanced escalation and de-escalation. Results suggest that NC and SSP models are interchangeable on a group-level and nearly so on a patient level and that SSP models can be derived to closely match clinical tests.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Staaf, Johan
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Häkkinen, Jari
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Hegardt, Cecilia
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Saal, Lao H
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Kimbung, Siker
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Hedenfalk, Ingri ...
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show more...
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Lien, Tonje
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Sørlie, Therese
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Naume, Bjørn
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Russnes, Hege
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Marcone, Rachel
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Ayyanan, Ayyakka ...
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Brisken, Cathrin
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Malterling, Rebe ...
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Asking, Bengt
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Olofsson, Helena
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Lindman, Henrik
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Bendahl, Pär-Ola
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Ehinger, Anna
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Larsson, Christe ...
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Loman, Niklas
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Rydén, Lisa
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Malmberg, Martin
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Borg, Åke
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Vallon-Christers ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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npj Breast Cance ...
- By the university
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Uppsala University
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Lund University