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  • Chye, Alexander (author)

Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke : AFFINITY Study Findings

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Ovid Technologies (Wolters Kluwer Health),2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-484032
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-484032URI
  • https://doi.org/10.1161/JAHA.121.025425DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We compare repeated-measures and single-measure analyses of the mRS from a randomized clinical trialMethods and Results: Serial mRS data from AFFINITY (Assessment of Fluoxetine in Stroke Recovery), a double-blind placebo randomized clinical trial of fluoxetine following stroke (n=1280) were analyzed to identify demographic and clinical associations with functional recovery (reduction in mRS) over 12 months. Associations were identified using single-measure (day 365) and repeated-measures (days 28, 90, 180, and 365) partial proportional odds logistic regression. Ninety-five percent of participants experienced a reduction in mRS after 12 months. Functional recovery was associated with age at stroke <70 years; no prestroke history of diabetes, coronary heart disease, or ischemic stroke; prestroke history of depression, a relationship partner, living with others, independence, or paid employment; no fluoxetine intervention; ischemic stroke (compared with hemorrhagic); stroke treatment in Vietnam (compared with Australia or New Zealand); longer time since current stroke; and lower baseline National Institutes of Health Stroke Scale & Patient Health Questionnaire-9 scores. Direction of associations was largely concordant between single-measure and repeated-measures models. Association strength and variance was generally smaller in the repeated-measures model compared with the single-measure model.Conclusions: Repeated-measures may improve trial precision in identifying trial associations and effects. Further repeated-measures stroke analyses are required to prove methodological value. Registration URL: http://www.anzctr.org.au; Unique identifier: ACTRN12611000774921.

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  • Hackett, Maree L (author)
  • Hankey, Graeme J (author)
  • Lundström, Erik,1964-Uppsala universitet,Neurologi(Swepub:uu)erlun676 (author)
  • Almeida, Osvaldo P (author)
  • Gommans, John (author)
  • Dennis, Martin (author)
  • Jan, Stephen (author)
  • Mead, Gillian E (author)
  • Ford, Andrew H (author)
  • Beer, Christopher Etherton (author)
  • Flicker, Leon (author)
  • Delcourt, Candice (author)
  • Billot, Laurent (author)
  • Anderson, Craig S (author)
  • Stibrant Sunnerhagen, Katharina (author)
  • Yi, Qilong (author)
  • Bompoint, Severine (author)
  • Nguyen, Thang Huy (author)
  • Lung, Thomas (author)
  • Uppsala universitetNeurologi (creator_code:org_t)

Related titles

  • In:Journal of the American Heart Association: Ovid Technologies (Wolters Kluwer Health)11:162047-9980

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