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Trans Fatty Acid Bi...
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Lai, Heidi T. M.Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.
(author)
Trans Fatty Acid Biomarkers and Incident Type 2 Diabetes : Pooled Analysis of 12 Prospective Cohort Studies in the Fatty Acids and Outcomes Research Consortium (FORCE)
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-02-10
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American Diabetes Association,2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-484219
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-484219URI
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https://doi.org/10.2337/dc21-1756DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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OBJECTIVE: Trans fatty acids (TFAs) have harmful biologic effects that could increase the risk of type 2 diabetes (T2D), but evidence remains uncertain. We aimed to investigate the prospective associations of TFA biomarkers and T2D by conducting an individual participant-level pooled analysis.RESEARCH DESIGN AND METHODS: We included data from an international consortium of 12 prospective cohorts and nested case-control studies from six nations. TFA biomarkers were measured in blood collected between 1990 and 2008 from 25,126 participants aged >= 18 years without prevalent diabetes. Each cohort conducted de novo harmonized analyses using a prespecified protocol, and findings were pooled using inverse-variance weighted meta-analysis. Heterogeneity was explored by prespecified between-study and within-study characteristics.RESULTS: During a mean follow-up of 13.5 years, 2,843 cases of incident T2D were identified. In multivariable-adjusted pooled analyses, no significant associations with T2D were identified for trans/trans-18:2, relative risk (RR) 1.09 (95% CI 0.94-1.25); cis/trans-18:2, 0.89 (0.73-1.07); and trans/cis-18:2, 0.87 (0.73-1.03). Trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated with T2D (RR 0.81 [95% CI 0.67-0.99], 0.86 [0.75-0.99], and 0.84 [0.74-0.96], respectively). Findings were not significantly different according to prespecified sources of potential heterogeneity (each P >= 0.1).CONCLUSIONS: Circulating individual trans-18:2 TFA biomarkers were not associated with risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 were inversely associated. Findings may reflect the influence of mixed TFA sources (industrial vs. natural ruminant), a general decline in TFA exposure due to policy changes during this period, or the relatively limited range of TFA levels.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Imamura, FumiakiUniv Cambridge, MRC Epidemiol Unit, Cambridge, England.
(author)
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Korat, Andres V. ArdissonHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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Murphy, Rachel A.Univ British Columbia, Fac Med, Sch Populat & Publ Hlth, Vancouver, BC, Canada.
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Tintle, NathanDordt Univ, Dept Math & Stat, Sioux Ctr, IA USA.;Fatty Acid Res Inst, Sioux Falls, SD USA.
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Bassett, Julie K.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.
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Chen, JiayingBrigham & Womens Hosp, Div Aging, Boston, MA USA.
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Kröger, JanineGerman Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.
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Chien, Kuo-LiongNatl Taiwan Univ, Coll Publ Hlth, Inst Epidemiol & Prevent Med, Taipei, Taiwan.
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Senn, MackenzieARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA.
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Wood, Alexis C.ARS, USDA, Childrens Nutr Res Ctr, Dept Pediat,Baylor Coll Med, Houston, TX USA.
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Forouhi, Nita G.Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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Schulze, Matthias B.German Inst Human Nutr Potsdam Rehbrucke, Dept Mol Epidemiol, Nuthetal, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany.;Univ Potsdam, Inst Nutr Sci, Nuthetal, Germany.
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Harris, William S.Fatty Acid Res Inst, Sioux Falls, SD USA.;Univ South Dakota, Sanford Sch Med, Dept Internal Med, Sioux Falls, SD USA.
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Vasan, Ramachandran S.Boston Univ, Sch Med, Boston, MA 02118 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA USA.
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Hu, FrankHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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Giles, Graham G.Canc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Epidemiol & Biostat, Parkville, Vic, Australia.;Monash Univ, Sch Clin Sci Monash Hlth, Precis Med, Clayton, Vic, Australia.
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Hodge, AllisonCanc Council Victoria, Canc Epidemiol Div, Melbourne, Vic, Australia.
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Djousse, LucHarvard Med Sch, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Div Aging, Boston, MA USA.
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Brouwer, Ingeborg A.Vrije Univ Amsterdam, Fac Sci, Amsterdam Publ Hlth Res Inst, Dept Hlth Sci, Amsterdam, Netherlands.
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Qian, FrankHarvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.
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Sun, QiHarvard TH Chan Sch Publ Hlth, Dept Nutr & Epidemiol, Boston, MA USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
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Wu, Jason H. Y.Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia.
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Marklund, MattiUppsala universitet,Klinisk nutrition och metabolism,Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA; Univ New South Wales, Fac Med, George Inst Global Hlth, Sydney, NSW, Australia(Swepub:uu)matma701
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Lemaitre, Rozenn N.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.
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Siscovick, David S.New York Acad Med, New York, NY USA.
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Fretts, Amanda M.Univ Washington, Dept Epidemiol, Sch Publ Hlth, Cardiovasc Hlth Res Unit, Seattle, WA USA.
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Shadyab, Aladdin H.Univ Calif San Diego, Sch Med, Family Med & Publ Hlth, La Jolla, CA 92093 USA.
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Manson, JoAnn E.Harvard Med Sch, Brigham & Womens Hosp, Dept Med, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
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Howard, Barbara, VGeorgetown Univ, Med Ctr, Hyattsville, MD USA.
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Robinson, Jennifer G.Univ Iowa, Iowa City, IA USA.
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Wallace, Robert B.Univ Iowa, Iowa City, IA USA.
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Wareham, Nick J.Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
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Chen, Yii-Der IdaHarbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.
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Rotter, Jerome, IHarbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA USA.
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Tsai, Michael Y.Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA.
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Micha, RenataTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.
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Mozaffarian, DariushTufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.
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Tufts Univ, Friedman Sch Nutr Sci & Policy, Boston, MA 02155 USA.;Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.Univ Cambridge, MRC Epidemiol Unit, Cambridge, England.
(creator_code:org_t)
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In:Diabetes Care: American Diabetes Association45:4, s. 854-8630149-59921935-5548
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Lai, Heidi T. M.
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Imamura, Fumiaki
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Korat, Andres V. ...
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Murphy, Rachel A ...
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Tintle, Nathan
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Bassett, Julie K ...
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Chen, Jiaying
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Kröger, Janine
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Chien, Kuo-Liong
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Senn, Mackenzie
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Wood, Alexis C.
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Forouhi, Nita G.
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Schulze, Matthia ...
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Harris, William ...
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Vasan, Ramachand ...
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Hu, Frank
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Giles, Graham G.
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Hodge, Allison
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Djousse, Luc
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Brouwer, Ingebor ...
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Qian, Frank
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Sun, Qi
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Wu, Jason H. Y.
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Marklund, Matti
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Lemaitre, Rozenn ...
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Siscovick, David ...
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Fretts, Amanda M ...
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Shadyab, Aladdin ...
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Manson, JoAnn E.
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Howard, Barbara, ...
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Robinson, Jennif ...
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Wallace, Robert ...
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Wareham, Nick J.
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Chen, Yii-Der Id ...
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Rotter, Jerome, ...
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Tsai, Michael Y.
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Micha, Renata
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Mozaffarian, Dar ...
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