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Distribution of E- ...
Distribution of E- and N-cadherin in subgroups of non-functioning pituitary neuroendocrine tumours
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- Oystese, Kristin Astrid B. (författare)
- Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
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- Casar Borota, Olivera (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Uppsala Univ Hosp, Dept Clin Pathol, Uppsala, Sweden.
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- Berg-Johnsen, Jon (författare)
- Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.;Oslo Univ Hosp, Dept Neurosurg, Oslo, Norway.
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- Berg, Jens Petter (författare)
- Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
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- Bollerslev, Jens (författare)
- Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway.;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway.
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Oslo Univ Hosp, Dept Endocrinol Morbid Obes & Prevent Med, Oslo, Norway;Univ Oslo, Fac Med, Inst Clin Med, Oslo, Norway. Institutionen för immunologi, genetik och patologi (creator_code:org_t)
- 2022-06-08
- 2022
- Engelska.
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Ingår i: Endocrine. - : Springer Nature. - 1355-008X .- 1559-0100. ; 77:1, s. 151-159
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Purpose Clinically non-functioning pituitary neuroendocrine tumours (NF-PitNETs) present a varying degree of aggressiveness, and reliable prognostic markers are lacking. We aimed to characterise the distribution of E- and N-cadherin in corticotroph, PIT1 and null-cell NF-PitNETs, and link it to the course of the tumours. Methods The distribution of E- and N-cadherin was investigated by immunohistochemistry in a retrospective cohort of 30 tumours of the less common NF-PitNETs (corticotroph (N = 18), PIT1 (N = 8) and null-cell PitNETs (N = 4)). Immunoreactive scores (IRS) were compared to previously presented cohorts of gonadotroph NF-PitNETs (N = 105) and corticotroph functioning PitNETs (N = 17). Results We found a low IRS for the extra-cellular domain of E-cadherin (median 0 (IQR 0-0, N = 135)), a medium to high IRS for the intra-cellular domain of E-cadherin (median 6 (IQR 4-9)) and a high IRS for N-cadherin (median 12 (IQR 10.5-12)) throughout the cohort of NF-PitNETs. The corticotroph NF-PitNETs presented a higher IRS for both the extra- and intra-cellular domain of E-cadherin (median 0 (IQR 0-1) and median 9 (IQR 6-12), respectively) than the gonadotroph NF-PitNETs (p < 0.001 for both comparisons). Presence of nuclear E-cadherin was associated with a weaker staining for the intra-cellular domain of E-cadherin (median 4 (IQR 0.5-6) and median 9 (IQR 9-12), for tumours with and without nuclear E-cadherin, respectively), and with a lower rate of re-intervention (p = 0.03). Conclusions Considering our results and the benign course of NF-PitNETs, we suggest that a high N-cadherin and downregulation of membranous E-cadherin are not associated with a more aggressive tumour behaviour in these subgroups of NF-PitNETs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Nyckelord
- Pituitary neuroendocrine tumours
- Non-functioning pituitary adenomas
- Corticotroph pituitary adenomas
- Adherence junctions
- Prognostic markers of pituitary tumours
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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