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Relationship between certain HLA alleles and the risk of cytomegalovirus reactivation following allogeneic hematopoietic stem cell transplantation

Prem, Shruti (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Remberger, Mats, Professor, 1955- (författare)
Uppsala universitet,Hematologi,Uppsala Univ Hosp, KFUE, Uppsala, Sweden.
Alotaibi, Ahmad (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
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Lam, Wilson (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Law, Arjun Datt (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Kim, Dennis (Dong Hwan) (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Michelis, Fotios, V (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Al-Shaibani, Zeyad (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Lipton, Jeffrey Howard (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Mattsson, Jonas (författare)
Karolinska Institutet
Viswabandya, Auro (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Kumar, Rajat (författare)
Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada.;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada.
Ellison, Cynthia (författare)
Univ Hlth Network, Messner Allogene Transplant Program, Div HLA Lab, Lab Med Program, Toronto, ON, Canada.;Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada.
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Univ Toronto, Sect Med Oncol & Hematol, Dept Med, Toronto, ON, Canada;Univ Hlth Network, Div Med Oncol & Hematol, Hans Messner Allogene Blood & Marrow Transplantat, Princess Margaret Canc Ctr, Toronto, ON, Canada. Hematologi (creator_code:org_t)
2022-07-13
2022
Engelska.
Ingår i: Transplant Infectious Disease. - : John Wiley & Sons. - 1398-2273 .- 1399-3062. ; 24:4
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Introduction: Evidence is emerging to support an association between certain human leukocyte antigen (HLA) alleles and the risk of cytomegalovirus (CMV) reactivation following allogeneic hematopoietic stem cell transplant (allo-HSCT). The primary aim of this study was to identify HLA alleles associated with resistance or susceptibility to CMV reactivation. Methods: We studied 586 adults who underwent al lo-HSCT for high-risk hematological malignancies. High-resolution HLA typing data were available for recipients and donors. HLA class I and II alleles observed at a frequency of >5% in our population were included in the analysis. A CMV viremia level of more than 200 IU/ml on weekly monitoring was considered to be indicative of CMV reactivation. Results: The median follow-up time in surviving patients was 21 months (range 4-74 months). The cumulative incidence of CMV reactivation at 6 months in the entire cohort was 55% (95% confidence interval [CI] 50.8%-59.2%). Mismatched donors, increasing recipient age, occurrence of acute graft versus host disease and recipient CMV seropositivity were associated with an increased risk of CMV reactivation. HLA B*07:02 (hazard ratio 0.59, 95% CI 0.40-0.83) was associated with a decreased risk of CMV reactivation. Patients who developed CMV reactivation had a lower incidence of relapse, higher transplant-related mortality (TRM) and lower overall survival (OS) than those without CMV reactivation. There was an adverse correlation of OS and TRM with increasing numbers of CMV reactivations. Conclusion: We observed that HLA B*07:02 was associated with a decreased risk of CMV reactivation. CMV reactivation was associated with lower relapse post-transplant, but this did not translate into a survival benefit due to higher TRM.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Hematologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Hematology (hsv//eng)

Nyckelord

allogenic hematopoietic stem cell transplant
cytomegalovirus reactivation
HLA alleles

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