Phonological working memory is adversely affected in adults with anorexia nervosa: a systematic literature review

Dahlén, AmeliaUppsala universitet,Institutionen för neurovetenskap,Funktionell farmakologi och neurovetenskap (författare)

Phonological working memory is adversely affected in adults with anorexia nervosa : a systematic literature review

Purpose Cognitive restraint has potentiating and deleterious effects on working memory (WM) in anorexia nervosa (AN). Conflicting evidence may be due to heterogeneity of tasks examining different WM components (e.g., verbal/auditory versus visuospatial), and differences in adolescent versus adult AN. Additionally, differential cognitive profiles of restricting versus binge/purging subtypes, comorbid psychiatric disorders and psychotropic medication use may confound findings.Methods To address these conflicts, 25 studies, published between 2016 and 2021, investigating WM in children, adolescents and adults with AN were systematically reviewed using PRISMA guidelines.Results In 71% of WM tasks, no difference in performance between AN patients and age-matched controls was reported, while 29% of WM tasks showed worse performance. Adults with AN displayed deficits in 44% of the verbal/auditory tasks, while performance remained unaffected in 86% of visuospatial tasks.Conclusion Examining age groups and WM subsystems separately revealed novel findings of differentially affected WM components in AN. Comorbidities and psychotropic medications were common among AN participants and should be regarded as critical confounding factors for WM measures. Future studies examining different components of WM, acknowledging these confounding factors, may reveal specific deficits in AN to aid treatment improvement strategies.

Gaudio, SantinoUppsala universitet,Institutionen för neurovetenskap,Funktionell farmakologi och neurovetenskap,Univ Roma Tor Vergata, Dept Biomed & Prevent, I-00133 Rome, Italy(Swepub:uu)sanga517 (författare)
Schiöth, Helgi B.Uppsala universitet,Funktionell farmakologi och neurovetenskap,Institutionen för neurovetenskap,IM Sechenov First Moscow State Med Univ, Inst Translat Med & Biotechnol, Moscow, Russia(Swepub:uu)helgschi (författare)
Brooks, SamanthaUppsala universitet,Institutionen för neurovetenskap,Funktionell farmakologi och neurovetenskap,Liverpool John Moores Univ, Sch Psychol, Fac Hlth, Liverpool, Merseyside, England.;Univ Witwatersrand, Sch Human & Community Dev, Dept Psychol, Neurosci Res Lab NeuRL, Johannesburg, South Africa(Swepub:uu)sambr210 (författare)
Uppsala universitetInstitutionen för neurovetenskap (creator_code:org_t)

Ingår i:Eating and Weight Disorders: Springer27:6, s. 1931-19521124-49091590-1262

Av författaren/redakt...: Dahlén, Amelia; Gaudio, Santino; Schiöth, Helgi B ...; Brooks, Samantha

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Psykiatri

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