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  • Sun, YingShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)

Joint Exposure to Positive Affect, Life Satisfaction, Depressive Symptoms, and Neuroticism and Incident Type 2 Diabetes

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-05-12
  • The Endocrine Society,2022
  • printrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-485480
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485480URI
  • https://doi.org/10.1210/clinem/dgac304DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149711846URI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Context Whether the psychological wellbeing status could be a risk factor for type 2 diabetes is unclear. Objective We aimed to measure the association between combined psychological wellbeing factors and type 2 diabetes and investigate whether this association was modified by genetic predisposition. Methods Prospective cohort study from the UK Biobank. In total, 127 496 participants who completed a psychological wellbeing questionnaire and did not have type 2 diabetes at baseline (2006-2010) were included; among them, 88 584 (69.5%) were analyzed to determine their genetic predisposition. The main outcome measure was incident type 2 diabetes. Results During the median follow-up of 10.0 years, 2547 incident type 2 diabetes cases were documented. Moderate to extreme unhappiness, satisfaction score <= 3, presence of broad depression, and a neuroticism score >= 3 were all significantly and independently associated with an increased risk of diabetes. When considered as a combination indicator, compared with individuals in the highest quartile of the psychological wellbeing score, the fully adjusted hazard ratios (95% CI) of type 2 diabetes were 1.41 (1.21-1.65) in the third quartile, 1.45 (1.24-1.69) in the second quartile, and 1.73 (1.48-2.01) in the lowest quartile. In the stratified analysis, we observed significant interactions between age and physical activity, and type 2 diabetes (P-interaction < .001 and 0.049, respectively). However, there was no significant interaction between the psychological wellbeing score and genetic susceptibility to diabetes (P-interaction = .980). Conclusion Worse overall psychological wellbeing was associated with a significantly increased risk of type 2 diabetes in a dose-response fashion regardless of genetic predisposition.

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  • Yu, YuefengShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Zhang, HaojieShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Wang, BinShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Chen, ChiShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Wang, YuyingShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Tan, XiaoKarolinska Institutet,Uppsala universitet,Institutionen för neurovetenskap,Karolinska Inst, Dept Clin Neurosci, Solna, Sweden.(Swepub:uu)xzata683 (author)
  • Zhang, JihuiGuangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Mental Hlth Ctr, Guangzhou, Guangdong, Peoples R China. (author)
  • Chen, YiShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Xia, FangzhenShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Lu, YingliShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Wang, NingjianShanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China. (author)
  • Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Inst & Dept Endocrinol & Metab, Shanghai 200011, Peoples R China.Institutionen för neurovetenskap (creator_code:org_t)

Related titles

  • In:Journal of Clinical Endocrinology and Metabolism: The Endocrine Society107:8, s. E3186-E31930021-972X1945-7197

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