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Estimation of recur...
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Hageman, Steven H. J.Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands
(författare)
Estimation of recurrent atherosclerotic cardiovascular event risk in patients with established cardiovascular disease : the updated SMART2 algorithm
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-02-15
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Oxford University Press,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-485619
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485619URI
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https://doi.org/10.1093/eurheartj/ehac056DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:149049652URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Aims The 10-year risk of recurrent atherosclerotic cardiovascular disease (ASCVD) events in patients with established ASCVD can be estimated with the Secondary Manifestations of ARTerial disease (SMART) risk score, and may help refine clinical management. To broaden generalizability across regions, we updated the existing tool (SMART2 risk score) and recalibrated it with regional incidence rates and assessed its performance in external populations.Methods and results Individuals with coronary artery disease, cerebrovascular disease, peripheral artery disease, or abdominal aortic aneurysms were included from the Utrecht Cardiovascular Cohort-SMART cohort [n = 8355; 1706 ASCVD events during a median follow-up of 8.2 years (interquartile range 4.2-12.5)] to derive a 10-year risk prediction model for recurrent ASCVD events (non-fatal myocardial infarction, non-fatal stroke, or cardiovascular mortality) using a Fine and Gray competing risk-adjusted model. The model was recalibrated to four regions across Europe, and to Asia (excluding Japan), Japan, Australia, North America, and Latin America using contemporary cohort data from each target region. External validation used data from seven cohorts [Clinical Practice Research Datalink, SWEDEHEART, the international REduction of Atherothrombosis for Continued Health (REACH) Registry, Estonian Biobank, Spanish Biomarkers in Acute Coronary Syndrome and Biomarkers in Acute Myocardial Infarction (BACS/BAMI), the Norwegian COgnitive Impairment After STroke, and Bialystok PLUS/Polaspire] and included 369 044 individuals with established ASCVD of whom 62 807 experienced an ASCVD event. C-statistics ranged from 0.605 [95% confidence interval (CI) 0.547-0.664] in BACS/BAMI to 0.772 (95% CI 0.659-0.886) in REACH Europe high-risk region. The clinical utility of the model was demonstrated across a range of clinically relevant treatment thresholds for intensified treatment options.Conclusion The SMART2 risk score provides an updated, validated tool for the prediction of recurrent ASCVD events in patients with established ASCVD across European and non-European populations. The use of this tool could allow for a more personalized approach to secondary prevention based upon quantitative rather than qualitative estimates of residual risk.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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McKay, Ailsa J.Imperial Coll London, Dept Primary Care & Publ Hlth, London, England
(författare)
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Ueda, PeterKarolinska Institutet
(författare)
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Gunn, Laura H.Imperial Coll London, Dept Primary Care & Publ Hlth, London, England.;Univ North Carolina Charlotte, Dept Publ Hlth Sci, Charlotte, NC USA.;Univ North Carolina Charlotte, Sch Data Sci, Charlotte, NC USA
(författare)
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Jernberg, TomasKarolinska Institutet
(författare)
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Hagström, EmilUppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)emhag677
(författare)
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Bhatt, Deepak L.Harvard Med Sch, Brigham & Womens Hosp, Heart & Vasc Ctr, Boston, MA 02115 USA
(författare)
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Steg, Ph GabrielUniv Paris, Hop Bichat, AP HP, INSERM Unite,French Alliance Cardiovasc Trials, F-1148 Paris, France
(författare)
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Lall, KristiUniv Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
(författare)
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Magi, ReedikUniv Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
(författare)
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Gynnild, Mari NordboNTNU Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway.;Trondheim Reg & Univ Hosp, Dept Stroke, Clin Med, St Olavs Hosp, Trondheim, Norway
(författare)
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Ellekjaer, HanneNTNU Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway.;Trondheim Reg & Univ Hosp, Dept Stroke, Clin Med, St Olavs Hosp, Trondheim, Norway
(författare)
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Saltvedt, IngvildNTNU Norwegian Univ Sci & Technol, Fac Med & Hlth Sci, Dept Neuromed & Movement Sci, Trondheim, Norway.;Trondheim Reg & Univ Hosp, Dept Geriatr, Clin Med, St Olavs Hosp, Trondheim, Norway
(författare)
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Tunon, JoseUniv Autonoma Madrid, Fdn Jimenez Diaz, Dept Cardiol, Madrid, Spain.;CIBERCV, Madrid, Spain
(författare)
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Mahillo, IgnacioFdn Jimenez Diaz, Dept Epidemiol, Madrid, Spain
(författare)
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Acena, AlvaroUniv Autonoma Madrid, Fdn Jimenez Diaz, Dept Cardiol, Madrid, Spain
(författare)
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Kaminski, KarolMed Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland
(författare)
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Chlabicz, MalgorzataMed Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland.;Med Univ Bialystok, Dept Invas Cardiol, Bialystok, Poland
(författare)
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Sawicka, EmiliaMed Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland.;Med Univ Bialystok, Dept Cardiol, Bialystok, Poland
(författare)
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Tillman, TaaviUCL, Ctr Noncommunicable Dis, Inst Global Hlth, London, England
(författare)
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McEvoy, John W.Natl Inst Prevent & Cardiovasc Hlth, Galway, Ireland.;Natl Univ Ireland Galway, Galway Campus, Galway, Ireland
(författare)
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Di Angelantonio, EmanueleUniv Cambridge, Dept Publ Hlth & Primary Care, Cardiovasc Epidemiol Unit, Cambridge, England
(författare)
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Graham, IanUniv Dublin, Trinity Coll Dublin, Sch Med, Dublin, Ireland
(författare)
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De Bacquer, DirkUniv Ghent, Dept Publ Hlth & Primary Care, Ghent, Belgium
(författare)
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Ray, Kausik K.Imperial Coll London, Dept Primary Care & Publ Hlth, London, England
(författare)
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Dorresteijn, Jannick A. N.Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands
(författare)
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Visseren, Frank L. J.Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, Netherlands
(författare)
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Univ Med Ctr Utrecht, Dept Vasc Med, POB 85500, NL-3508 GA Utrecht, NetherlandsImperial Coll London, Dept Primary Care & Publ Hlth, London, England
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Heart Journal: Oxford University Press43:18, s. 1715-17270195-668X1522-9645
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Till lärosätets databas
- Av författaren/redakt...
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Hageman, Steven ...
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McKay, Ailsa J.
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Ueda, Peter
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Gunn, Laura H.
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Jernberg, Tomas
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Hagström, Emil
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visa fler...
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Bhatt, Deepak L.
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Steg, Ph Gabriel
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Lall, Kristi
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Magi, Reedik
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Gynnild, Mari No ...
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Ellekjaer, Hanne
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Saltvedt, Ingvil ...
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Tunon, Jose
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Mahillo, Ignacio
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Acena, Alvaro
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Kaminski, Karol
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Chlabicz, Malgor ...
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Sawicka, Emilia
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Tillman, Taavi
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McEvoy, John W.
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Di Angelantonio, ...
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Graham, Ian
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De Bacquer, Dirk
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Ray, Kausik K.
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Dorresteijn, Jan ...
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Visseren, Frank ...
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visa färre...
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och Klinisk medicin
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och Kardiologi
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European Heart J ...
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Uppsala universitet
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Karolinska Institutet