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  • Linde, CeciliaKarolinska Institutet (author)

Baseline characteristics of 547 new onset heart failure patients in the PREFERS heart failure study

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-04-10
  • John Wiley & Sons,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-485796
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485796URI
  • https://doi.org/10.1002/ehf2.13922DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149246310URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aim We present the baseline characteristics of the PREFERS Stockholm epidemiological study on the natural history and course of new onset heart failure (HF) aiming to improve phenotyping focusing on HF with preserved left ventricular ejection fraction (HFpEF) pathophysiology.Methods and results New onset HF patients diagnosed in hospital or at outpatient HF clinics were included at five Stockholm hospitals 2015-2018 and characterized by N-terminal pro brain natriuretic peptide (NT-proBNP), biomarkers, echocardiography, and cardiac magnetic resonance imaging (subset). HFpEF [left ventricular ejection fraction (LVEF) >= 50%) was compared with HF with mildly reduced LVEF (HFmrEF; LVEF 41-49%) and with HF with reduced LVEF (HFrEF; LVEF <= 40%). We included 547 patients whereof HFpEF (n = 137; 25%), HFmrEF (n = 61; 11%), and HFrEF (n = 349; 64%). HFpEF patients were older (76; 70-81 years; median; interquartile range) than HFrEF (67; 58-74; P < 0.001), more often women (49% vs. 30%; P < 0.001), and had significantly higher comorbidity burden. They more often had atrial fibrillation, hypertension, and renal dysfunction. NT-proBNP was lower in HFpEF (896; 462-1645 ng/L) than in HFrEF (1160; 563-2370; P = 0.005). In HFpEF, left ventricular (LV) diameters and volumes were smaller (P < 0.001) and septa! and posterior wall thickness and relative wall thickness higher (P < 0.001). E/e >= 14 was present in 26% of HFpEF vs. 32% of HFrEF (P = 0.017) and left atrial volume index > 34 mL/m(2) in 57% vs. 61% (P = 0.040). HFmrEF patients were intermediary between HFpEF and HFrEF for LV mass, LV volumes, and RV volumes but had the highest proportion of left ventricular hypertrophy and the lowest proportion of elevated E/e.Conclusions Phenotype data in new onset HF patients recruited in a broad clinical setting showed that 25% had HFpEF, were older, more often women, and had greater comorbidity burden. PREFERS is well suited to further explore biomarker and imaging components of HFpEF pathophysiology and may contribute to the emerging knowledge of HF epidemiology.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Ekstrom, MattiasKarolinska Institutet (author)
  • Eriksson, Maria J.Karolinska Institutet (author)
  • Maret, EvaKarolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Physiol, Stockholm, Sweden (author)
  • Wallen, HakanKarolinska Institutet (author)
  • Lynga, PatrikKarolinska Institutet (author)
  • Weden, UllaKarolinska Univ Hosp, Dept Cardiol, S-17176 Stockholm, Sweden (author)
  • Cabrera, CarinKarolinska Institutet (author)
  • Lofstrom, UlrikaKarolinska Institutet (author)
  • Stenudd, JennyDanderyd Hosp, Dept Cardiol, Stockholm, Sweden (author)
  • Lund, Lars H.Karolinska Institutet (author)
  • Persson, BengtUppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för cell- och molekylärbiologi,Karolina Inst, Dept Med Biochem & Biophys, Sci Life Lab, Stockholm, Sweden(Swepub:uu)benpe457 (author)
  • Persson, HansKarolinska Institutet (author)
  • Hage, CamillaKarolinska Inst, Dept Med, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Cardiol, S-17176 Stockholm, Sweden (author)
  • Karolinska InstitutetKarolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.;Karolinska Univ Hosp, Dept Clin Physiol, Stockholm, Sweden (creator_code:org_t)

Related titles

  • In:ESC Heart Failure: John Wiley & Sons9:4, s. 2125-21382055-5822

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