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Angiocrine polyamin...
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Monelli, ErikaJosep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
(author)
Angiocrine polyamine production regulates adiposity
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-03-14
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Springer Nature,2022
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-485876
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485876URI
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https://doi.org/10.1038/s42255-022-00544-6DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of angiogenesis upon WAT expansion, a process that is impaired in obesity. However, the molecular mechanisms underlying the crosstalk between ECs and adipocytes remain poorly understood. Here, we show that local production of polyamines in ECs stimulates adipocyte lipolysis and regulates WAT homeostasis in mice. We promote enhanced cell-autonomous angiogenesis by deleting Pten in the murine endothelium. Endothelial Pten loss leads to a WAT-selective phenotype, characterized by reduced body weight and adiposity in pathophysiological conditions. This phenotype stems from enhanced fatty acid beta-oxidation in ECs concomitant with a paracrine lipolytic action on adipocytes, accounting for reduced adiposity. Combined analysis of murine models, isolated ECs and human specimens reveals that WAT lipolysis is mediated by mTORC1-dependent production of polyamines by ECs. Our results indicate that angiocrine metabolic signals are important for WAT homeostasis and organismal metabolism. Endothelial cells in white adipose tissue are shown to produce polyamines, which regulate adipocyte lipolysis, thus demonstrating how local angiocrine signals contribute to healthy adipose tissue homeostasis.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Villacampa, PilarJosep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
(author)
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Zabala-Letona, AmaiaBasque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
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Martinez-Romero, AnabelJosep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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Llena, JudithJosep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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Beiroa, DanielUniv Santiago de Compostela, CIMUS, Inst Invest Sanitaria, Santiago De Compostela, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
(author)
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Gouveia, LeonorUppsala universitet,Vaskulärbiologi,Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain(Swepub:uu)margo865
(author)
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Chivite, InigoInst Invest Biomed August Pi & Sunyer IDIBAPS, Neuronal Control Metab Lab, Barcelona, Spain
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Zagmutt, SebastianUniv Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain
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Gama-Perez, PauUniv Barcelona, Fac Med & Hlth Sci, Dept Physiol Sci, Barcelona, Spain.;Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain
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Osorio-Conles, OscarUniv Barcelona, Hosp Clin, Dept Endocrinol, IDIBAPS, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
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Muixi, LaiaJosep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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Martinez-Gonzalez, AinaraBasque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain
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Castillo, Sandra D.Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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Martin-Martin, NataliaBasque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.;Biocruces Bizkaia Hlth Res Inst, Traslat Prostate Canc Res Lab, CIC BioGUNE Basurto, Baracaldo, Spain
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Castel, PauNYU, Grossman Sch Med, Dept Biochem & Mol Pharmacol, New York, NY USA
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Valcarcel-Jimenez, LoreaBasque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain
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Garcia-Gonzalez, IreneCtr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain
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Villena, Josep A.Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.;Univ Autonoma Barcelona, Vall dHebron Inst Recerca, Lab Metab & Obes, Barcelona, Spain
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Fernandez-Ruiz, SoniaBasque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain
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Serra, DolorsInst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain
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Herrero, LauraInst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain
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Benedito, RuiCtr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain
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Garcia-Roves, PabloInst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Univ Barcelona, Fac Med & Hlth Sci, Dept Physiol Sci, Barcelona, Spain.;Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain
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Vidal, JosepUniv Barcelona, Hosp Clin, Dept Endocrinol, IDIBAPS, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
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Cohen, PaulRockefeller Univ, Lab Mol Metab, 1230 York Ave, New York, NY 10021 USA
(author)
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Nogueiras, RubenUniv Santiago de Compostela, CIMUS, Inst Invest Sanitaria, Santiago De Compostela, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Xunta Galicia, Galician Agcy Invest, La Coruna, Spain
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Claret, MarcInst Invest Biomed August Pi & Sunyer IDIBAPS, Neuronal Control Metab Lab, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
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Carracedo, ArkaitzBasque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.;Biocruces Bizkaia Hlth Res Inst, Traslat Prostate Canc Res Lab, CIC BioGUNE Basurto, Baracaldo, Spain.;Univ Basque Country UPV EHU, Biochem & Mol Biol Dept, Bilbao, Spain.;Basque Fdn Sci, Ikerbasque, Bilbao, Spain
(author)
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Graupera, MarionaJosep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
(author)
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Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, SpainBasque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
(creator_code:org_t)
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In:Nature Metabolism: Springer Nature4:3, s. 327-+2522-5812
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Monelli, Erika
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Villacampa, Pila ...
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Zabala-Letona, A ...
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Martinez-Romero, ...
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Llena, Judith
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Beiroa, Daniel
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Gouveia, Leonor
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Chivite, Inigo
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Zagmutt, Sebasti ...
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Gama-Perez, Pau
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Osorio-Conles, O ...
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Muixi, Laia
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Martinez-Gonzale ...
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Castillo, Sandra ...
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Martin-Martin, N ...
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Castel, Pau
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Valcarcel-Jimene ...
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Garcia-Gonzalez, ...
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Villena, Josep A ...
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Fernandez-Ruiz, ...
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Serra, Dolors
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Herrero, Laura
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Benedito, Rui
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Garcia-Roves, Pa ...
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Vidal, Josep
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Cohen, Paul
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Nogueiras, Ruben
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Claret, Marc
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Carracedo, Arkai ...
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Graupera, Marion ...
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