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Angiocrine polyamin...
Angiocrine polyamine production regulates adiposity
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- Monelli, Erika (författare)
- Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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- Villacampa, Pilar (författare)
- Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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- Zabala-Letona, Amaia (författare)
- Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
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visa fler...
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- Martinez-Romero, Anabel (författare)
- Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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- Llena, Judith (författare)
- Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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- Beiroa, Daniel (författare)
- Univ Santiago de Compostela, CIMUS, Inst Invest Sanitaria, Santiago De Compostela, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain
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- Gouveia, Leonor (författare)
- Uppsala universitet,Vaskulärbiologi,Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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- Chivite, Inigo (författare)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Neuronal Control Metab Lab, Barcelona, Spain
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- Zagmutt, Sebastian (författare)
- Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain
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- Gama-Perez, Pau (författare)
- Univ Barcelona, Fac Med & Hlth Sci, Dept Physiol Sci, Barcelona, Spain.;Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain
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- Osorio-Conles, Oscar (författare)
- Univ Barcelona, Hosp Clin, Dept Endocrinol, IDIBAPS, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
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- Muixi, Laia (författare)
- Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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- Martinez-Gonzalez, Ainara (författare)
- Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain
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- Castillo, Sandra D. (författare)
- Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain
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- Martin-Martin, Natalia (författare)
- Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.;Biocruces Bizkaia Hlth Res Inst, Traslat Prostate Canc Res Lab, CIC BioGUNE Basurto, Baracaldo, Spain
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- Castel, Pau (författare)
- NYU, Grossman Sch Med, Dept Biochem & Mol Pharmacol, New York, NY USA
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- Valcarcel-Jimenez, Lorea (författare)
- Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain
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- Garcia-Gonzalez, Irene (författare)
- Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain
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- Villena, Josep A. (författare)
- Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain.;Univ Autonoma Barcelona, Vall dHebron Inst Recerca, Lab Metab & Obes, Barcelona, Spain
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- Fernandez-Ruiz, Sonia (författare)
- Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain
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- Serra, Dolors (författare)
- Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain
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- Herrero, Laura (författare)
- Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Univ Barcelona, Inst Biomed Univ Barcelona IBUB, Sch Pharm & Food Sci, Dept Biochem & Physiol, Barcelona, Spain
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- Benedito, Rui (författare)
- Ctr Nacl Invest Cardiovasc CNIC, Mol Genet Angiogenesis Grp, Madrid, Spain
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- Garcia-Roves, Pablo (författare)
- Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Univ Barcelona, Fac Med & Hlth Sci, Dept Physiol Sci, Barcelona, Spain.;Bellvitge Biomed Res Inst IDIBELL, Barcelona, Spain
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- Vidal, Josep (författare)
- Univ Barcelona, Hosp Clin, Dept Endocrinol, IDIBAPS, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
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- Cohen, Paul (författare)
- Rockefeller Univ, Lab Mol Metab, 1230 York Ave, New York, NY 10021 USA
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- Nogueiras, Ruben (författare)
- Univ Santiago de Compostela, CIMUS, Inst Invest Sanitaria, Santiago De Compostela, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Fisiopatol Obesidad & Nutr, Madrid, Spain.;Xunta Galicia, Galician Agcy Invest, La Coruna, Spain
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- Claret, Marc (författare)
- Inst Invest Biomed August Pi & Sunyer IDIBAPS, Neuronal Control Metab Lab, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Diabet & Enfermedades Metab, Madrid, Spain
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- Carracedo, Arkaitz (författare)
- Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain.;Biocruces Bizkaia Hlth Res Inst, Traslat Prostate Canc Res Lab, CIC BioGUNE Basurto, Baracaldo, Spain.;Univ Basque Country UPV EHU, Biochem & Mol Biol Dept, Bilbao, Spain.;Basque Fdn Sci, Ikerbasque, Bilbao, Spain
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- Graupera, Mariona (författare)
- Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain.;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain
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visa färre...
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Josep Carreras Leukaemia Res Inst IJC, Endothelial Pathobiol & Microenviroment Grp, Barcelona, Spain Basque Res & Technol Alliance BRTA, Ctr Cooperat Res Biosci CIC BioGUNE, Bizkaia Technol Pk, Derio, Spain;Inst Salud Carlos III, Ctr Invest Biomed Red Canc CIBERONC, Madrid, Spain (creator_code:org_t)
- 2022-03-14
- 2022
- Engelska.
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Ingår i: Nature Metabolism. - : Springer Nature. - 2522-5812. ; 4:3, s. 327-
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Reciprocal interactions between endothelial cells (ECs) and adipocytes are fundamental to maintain white adipose tissue (WAT) homeostasis, as illustrated by the activation of angiogenesis upon WAT expansion, a process that is impaired in obesity. However, the molecular mechanisms underlying the crosstalk between ECs and adipocytes remain poorly understood. Here, we show that local production of polyamines in ECs stimulates adipocyte lipolysis and regulates WAT homeostasis in mice. We promote enhanced cell-autonomous angiogenesis by deleting Pten in the murine endothelium. Endothelial Pten loss leads to a WAT-selective phenotype, characterized by reduced body weight and adiposity in pathophysiological conditions. This phenotype stems from enhanced fatty acid beta-oxidation in ECs concomitant with a paracrine lipolytic action on adipocytes, accounting for reduced adiposity. Combined analysis of murine models, isolated ECs and human specimens reveals that WAT lipolysis is mediated by mTORC1-dependent production of polyamines by ECs. Our results indicate that angiocrine metabolic signals are important for WAT homeostasis and organismal metabolism. Endothelial cells in white adipose tissue are shown to produce polyamines, which regulate adipocyte lipolysis, thus demonstrating how local angiocrine signals contribute to healthy adipose tissue homeostasis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Monelli, Erika
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Villacampa, Pila ...
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Zabala-Letona, A ...
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Martinez-Romero, ...
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Llena, Judith
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Beiroa, Daniel
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visa fler...
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Gouveia, Leonor
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Chivite, Inigo
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Zagmutt, Sebasti ...
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Gama-Perez, Pau
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Osorio-Conles, O ...
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Muixi, Laia
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Martinez-Gonzale ...
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Castillo, Sandra ...
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Martin-Martin, N ...
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Castel, Pau
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Valcarcel-Jimene ...
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Garcia-Gonzalez, ...
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Villena, Josep A ...
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Fernandez-Ruiz, ...
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Serra, Dolors
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Herrero, Laura
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Benedito, Rui
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Garcia-Roves, Pa ...
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Vidal, Josep
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Cohen, Paul
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Nogueiras, Ruben
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Claret, Marc
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Carracedo, Arkai ...
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Graupera, Marion ...
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och Cell och molekyl ...
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Uppsala universitet