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Specification of CN...
Specification of CNS macrophage subsets occurs postnatally in defined niches
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- Masuda, Takahiro (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Mol & Syst Pharmacol, Fukuoka, Japan
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- Amann, Lukas (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany
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- Monaco, Gianni (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany
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- Sankowski, Roman (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Fac Med, Berta Ottenstein Programme Clinician Scientists, Freiburg, Germany
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- Staszewski, Ori (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Fac Med, Berta Ottenstein Programme Clinician Scientists, Freiburg, Germany
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Krueger, Martin (författare)
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- Del Gaudio, Francesca (författare)
- Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden
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- He, Liqun (författare)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Science for Life Laboratory, SciLifeLab
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- Paterson, Neil (författare)
- Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany.;Int Max Planck Res Sch Immunobiol Epigenet & Meta, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany
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- Nent, Elisa (författare)
- Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany
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- Fernandez-Klett, Francisco (författare)
- Charite Univ Med Berlin, Neuropsychiat, Berlin, Germany.;Charite Univ Med Berlin, Lab Mol Psychiat, Berlin, Germany.;DZNE, Berlin, Germany
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- Yamasaki, Ayato (författare)
- Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Mol & Syst Pharmacol, Fukuoka, Japan
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- Frosch, Maximilian (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany
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- Fliegauf, Maximilian (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Inst Pharmaceut Sci, Dept Pharmaceut Biol & Biotechnol, Freiburg, Germany
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- Bosch, Lance Fredrick Pahutan (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany
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- Ulupinar, Hatice (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Fac Biol, Freiburg, Germany
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- Hagemeyer, Nora (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany
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- Schreiner, Dietmar (författare)
- Hannover Med Sch, Inst Neuroanat & Cell Biol, Hannover, Germany
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- Dorrier, Cayce (författare)
- Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.;Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92103 USA
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- Tsuda, Makoto (författare)
- Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Mol & Syst Pharmacol, Fukuoka, Japan
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- Grothe, Claudia (författare)
- Hannover Med Sch, Inst Neuroanat & Cell Biol, Hannover, Germany
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- Joutel, Anne (författare)
- Univ Paris, Inst Psychiat & Neurosci Paris IPNP, INSERM, Paris, France
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- Daneman, Richard (författare)
- Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA.;Univ Calif San Diego, Dept Pharmacol, San Diego, CA 92103 USA
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- Betsholtz, Christer (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för immunologi, genetik och patologi,Karolinska Inst, Dept Med Huddinge MedH, Huddinge, Sweden
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- Lendahl, Urban (författare)
- Karolinska Inst, Dept Cell & Mol Biol, Stockholm, Sweden
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- Knobeloch, Klaus-Peter (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, CIBSS Ctr Integrat Biol Signalling Studies, Freiburg, Germany
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- Laemmermann, Tim (författare)
- Max Planck Inst Immunobiol & Epigenet, Freiburg, Germany
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- Priller, Josef (författare)
- Charite Univ Med Berlin, Neuropsychiat, Berlin, Germany.;Charite Univ Med Berlin, Lab Mol Psychiat, Berlin, Germany.;DZNE, Berlin, Germany.;Tech Univ Munich, Sch Med, Dept Psychiat & Psychotherapy, Munich, Germany.;Univ Edinburgh, Edinburgh, Midlothian, Scotland.;UK DRI, Edinburgh, Midlothian, Scotland
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- Kierdorf, Katrin (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, CIBSS Ctr Integrat Biol Signalling Studies, Freiburg, Germany.;Univ Freiburg, Fac Med, Ctr Basics NeuroModulat NeuroModulBasics, Freiburg, Germany
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- Prinz, Marco (författare)
- Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany.;Univ Freiburg, Fac Med, Ctr Basics NeuroModulat NeuroModulBasics, Freiburg, Germany.;Univ Freiburg, Signalling Res Ctr BIOSS, Freiburg, Germany.;Univ Freiburg, Signalling Res Ctr CIBSS, Freiburg, Germany
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Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany;Kyushu Univ, Grad Sch Pharmaceut Sci, Dept Mol & Syst Pharmacol, Fukuoka, Japan Univ Freiburg, Fac Med, Inst Neuropathol, Freiburg, Germany (creator_code:org_t)
- 2022-04-20
- 2022
- Engelska.
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Ingår i: Nature. - : Springer Nature. - 0028-0836 .- 1476-4687. ; 604:7907, s. 740-
- Relaterad länk:
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https://www.nature.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- All tissue-resident macrophages of the central nervous system (CNS)-including parenchymal microglia, as well as CNS-associated macrophages (CAMs(1)) such as meningeal and perivascular macrophages(2-)(7)-are part of the CNS endogenous innate immune system that acts as the first line of defence during infections or trauma(2,8-10). It has been suggested that microglia and all subsets of CAMs are derived from prenatal cellular sources in the yolk sac that were defined as early erythromyeloid progenitors(11-15). However, the precise ontogenetic relationships, the underlying transcriptional programs and the molecular signals that drive the development of distinct CAM subsets in situ are poorly understood. Here we show, using fate-mapping systems, single-cell profiling and cell-specific mutants, that only meningeal macrophages and microglia share a common prenatal progenitor. By contrast, perivascular macrophages originate from perinatal meningeal macrophages only after birth in an integrin-dependent manner. The establishment of perivascular macrophages critically requires the presence of arterial vascular smooth muscle cells. Together, our data reveal a precisely timed process in distinct anatomical niches for the establishment of macrophage subsets in the CNS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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Masuda, Takahiro
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Amann, Lukas
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Monaco, Gianni
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Sankowski, Roman
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Staszewski, Ori
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Krueger, Martin
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Del Gaudio, Fran ...
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He, Liqun
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Paterson, Neil
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Nent, Elisa
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Fernandez-Klett, ...
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Yamasaki, Ayato
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Frosch, Maximili ...
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Fliegauf, Maximi ...
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Bosch, Lance Fre ...
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Ulupinar, Hatice
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Hagemeyer, Nora
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Schreiner, Dietm ...
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Dorrier, Cayce
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Tsuda, Makoto
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Grothe, Claudia
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Joutel, Anne
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Daneman, Richard
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Betsholtz, Chris ...
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Lendahl, Urban
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Knobeloch, Klaus ...
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Laemmermann, Tim
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Priller, Josef
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Kierdorf, Katrin
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Prinz, Marco
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Nature
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Uppsala University
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Karolinska Institutet