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Sökning: id:"swepub:oai:DiVA.org:uu-485919" > Factor's that impac...

  • Buchanan, JamesUniv Oxford, Hlth Econ Res Ctr, Nuffield Dept Populat Hlth, Oxford, England.;Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England. (författare)

Factor's that impact on women's decision-making around prenatal genomic tests : An international discrete choice survey

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2022-04-30
  • John Wiley & Sons,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-485919
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485919URI
  • https://doi.org/10.1002/pd.6159DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:149425705URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective We conducted a survey-based discrete-choice experiment (DCE) to understand the test features that drive women's preferences for prenatal genomic testing, and explore variation across countries. Methods Five test attributes were identified as being important for decision-making through a literature review, qualitative interviews and quantitative scoring exercise. Twelve scenarios were constructed in which respondents choose between two invasive tests or no test. Women from eight countries who delivered a baby in the previous 24 months completed a DCE presenting these scenarios. Choices were modeled using conditional logit regression analysis. Results Surveys from 1239 women (Australia: n = 178; China: n = 179; Denmark: n = 88; Netherlands: n = 177; Singapore: n = 90; Sweden: n = 178; UK: n = 174; USA: n = 175) were analyzed. The key attribute affecting preferences was a test with the highest diagnostic yield (p < 0.01). Women preferred tests with short turnaround times (p < 0.01), and tests reporting variants of uncertain significance (VUS; p < 0.01) and secondary findings (SFs; p < 0.01). Several country-specific differences were identified, including time to get a result, who explains the result, and the return of VUS and SFs. Conclusion Most women want maximum information from prenatal genomic tests, but our findings highlight country-based differences. Global consensus on how to return uncertain results is not necessarily realistic or desirable.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hill, MelissaGreat Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England. (författare)
  • Vass, Caroline M.Univ Manchester, Manchester Ctr Hlth Econ, Manchester, Lancs, England.;RTI Hlth Solut, Manchester, Lancs, England. (författare)
  • Hammond, JenniferGreat Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England. (författare)
  • Riedijk, SamErasmus MC, Dept Clin Genet, Rotterdam, Netherlands. (författare)
  • Klapwijk, Jasmijn E.Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands. (författare)
  • Harding, EleanorUCL Great Ormond St Inst Child Hlth, BSc Paediat & Child Hlth, London, England. (författare)
  • Lou, StinaAarhus Univ, Ctr Fetal Diagnost, Dept Clin Med, Aarhus, Denmark.;DEFACTUM Publ Hlth & Hlth Serv Res, Cent Denmark Reg, Aarhus, Denmark. (författare)
  • Vogel, IdaAarhus Univ, Ctr Fetal Diagnost, Dept Clin Med, Aarhus, Denmark.;Aarhus Univ Hosp, Dept Clin Genet, Aarhus, Denmark. (författare)
  • Hui, LisaMurdoch Childrens Res Inst, Reprod Epidemiol Grp, Parkville, Vic, Australia.;Mercy Hosp Women, Dept Perinatal Med, Heidelberg, Vic, Australia.;Northern Hlth, Dept Obstet & Gynaecol, Epping, Vic, Australia. (författare)
  • Ingvoldstad, CharlottaUppsala universitet,Centrum för forsknings- och bioetik,Karolinska Univ Hosp, Ctr Fetal Med, Stockholm, Sweden.;Karolinska Inst, Karolinska Hosp, Dept Clin Genet, Stockholm, Sweden.;Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden.(Swepub:uu)cin24816 (författare)
  • Soller, Maria JohanssonKarolinska Institutet (författare)
  • Ormond, Kelly E.Stanford Univ, Sch Med, Dept Genet, Stanford, CA USA.;Stanford Univ, Sch Med, Stanford Ctr Biomed Eth, Stanford, CA USA.;Swiss Fed Inst Technol, Hlth Eth & Policy Lab, Dept Hlth Sci & Technol, Zurich, Switzerland. (författare)
  • Choolani, MaheshNatl Univ Singapore Hosp, Dept Obstet & Gynaecol, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore. (författare)
  • Zheng, QianGreat Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England. (författare)
  • Chitty, Lyn S.Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England. (författare)
  • Lewis, CelineGreat Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Populat Policy & Practice, London, England. (författare)
  • Univ Oxford, Hlth Econ Res Ctr, Nuffield Dept Populat Hlth, Oxford, England.;Natl Inst Hlth Res Oxford Biomed Res Ctr, Oxford, England.Great Ormond St Hosp Sick Children, North Thames Genom Lab Hub, London, England.;UCL Great Ormond St Inst Child Hlth, Genet & Genom Med, London, England. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Prenatal Diagnosis: John Wiley & Sons42:7, s. 934-9460197-38511097-0223

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