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Postoperative speec...
Postoperative speech impairment and cranial nerve deficits after secondary surgery of posterior fossa tumours in childhood : a prospective European multicentre study
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- Gronbaek, J. Kjaer (författare)
- Copenhagen Univ Hosp, Dept Neurosurg, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.;Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.
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- Toescu, S. (författare)
- Great Ormond St Hosp Sick Children, Dept Neurosurg, Great Ormond St, London WC1N 3JH, England.;UCL GOS Inst Child Hlth, Dev Imaging & Biophys Sect, 30 Guilford St, London WC1N 1EH, England.,Great Ormond Street Hospital,UCL Institute of Child Health
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- Fric, R. (författare)
- Oslo Univ Hosp, Dept Neurosurg, Postboks 4950 Nydalen, N-0424 Oslo, Norway.,Oslo university hospital
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- Nilsson, Pelle (författare)
- Uppsala universitet,Neurokirurgi,Uppsala University Hospital
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- Castor, C. (författare)
- Lund University,Lunds universitet,Barns och familjers hälsa,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Child and Family Health,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Alder Hey Children’s NHS Foundation Trust
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- Mallucci, C. (författare)
- Alder Hey Childrens NHS Fdn Trust, Dept Paediat Neurosurg, E Prescot Rd, Liverpool L14 5AB, Merseyside, England.
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- Pizer, B. (författare)
- Univ Liverpool, Sch Hlth & Life Sci, Brownlow Hill, Liverpool L69 3BX, Merseyside, England.,University of Liverpool
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- Aquilina, K. (författare)
- Great Ormond St Hosp Sick Children, Dept Neurosurg, Great Ormond St, London WC1N 3JH, England.,Great Ormond Street Hospital,Helsinki University Central Hospital
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- Molinari, E. (författare)
- Univ Glasgow, Queen Elizabeth Univ Hosp, Dept Neurol, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland.,Queen Elizabeth University Hospital, Glasgow
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- Hjort, M. Aasved (författare)
- St Olavs Hosp, Dept Pediat Hematol & Oncol, Postboks 3250 Torgarden, N-7006 Trondheim, Norway.,St. Olav’s University Hospital
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- Karppinen, A. (författare)
- Helsinki Univ Hosp, Dept Neurosurg, POB 266,N00029, Helsinki, Finland.;Univ Helsinki, POB 266,N00029, Helsinki, Finland.
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- Rutkauskiene, G. (författare)
- Lithuanian Univ Hlth Sci, Dept Pediat, Mickeviciaus 9, LT-44307 Kaunas, Lithuania.,Lithuanian University of Health Sciences
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- Mudra, K. (författare)
- Semmelweis Univ, Dept Pediat 2, Tuzolto St 79, Budapest, Hungary.
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- Markia, B. (författare)
- Natl Inst Mental Hlth, Neurol & Neurosurg, Laky Adolf U 44, H-1145 Budapest, Hungary.
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- van Baarsen, K. (författare)
- Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands.,Princess Maxima Center for Pediatric Oncology/Hematology
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- Hoving, E. (författare)
- Princess Maxima Ctr Pediat Oncol, Heidelberglaan 25, NL-3584 CS Utrecht, Netherlands.,Princess Maxima Center for Pediatric Oncology/Hematology
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- Zipfel, J. (författare)
- Univ Hosp Tuebingen, Dept Neurosurg, Pediat Neurosurg, Hoppe Seyler Str 3, D-72076 Tubingen, Germany.,University Hospital of Tubingen
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- Wibroe, M. (författare)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.,Copenhagen University Hospital
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- Nysom, K. (författare)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.,Copenhagen University Hospital
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- Schmiegelow, K. (författare)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.,University of Copenhagen,Copenhagen University Hospital
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- Sehested, A. (författare)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.,Copenhagen University Hospital
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- Mathiasen, R. (författare)
- Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.,Copenhagen University Hospital
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- Juhler, M. (författare)
- Copenhagen Univ Hosp, Dept Neurosurg, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark.;Univ Copenhagen, Fac Med, Inst Clin Med, Blegdamsvej 3B, DK-2200 Copenhagen, Denmark.;Aarhus Univ Hosp, Dept Neurosurg, Blvd 99, DK-8200 Aarhus, Denmark.,University of Copenhagen,Copenhagen University Hospital,Aarhus University Hospital
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- Grønbæk, J. Kjær (författare)
- Copenhagen University Hospital
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Copenhagen Univ Hosp, Dept Neurosurg, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark;Copenhagen Univ Hosp, Dept Paediat & Adolescent Med, Rigshosp, Blegdamsvej 9, DK-2100 Copenhagen E, Denmark. Great Ormond St Hosp Sick Children, Dept Neurosurg, Great Ormond St, London WC1N 3JH, England.;UCL GOS Inst Child Hlth, Dev Imaging & Biophys Sect, 30 Guilford St, London WC1N 1EH, England. (creator_code:org_t)
- 2022-02-14
- 2022
- Engelska.
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Ingår i: Child's Nervous System. - : Springer Nature. - 0256-7040 .- 1433-0350. ; 38:4, s. 747-758
- Relaterad länk:
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Purpose Brain tumours constitute 25% of childhood neoplasms, and half of them are in the posterior fossa. Surgery is a fundamental component of therapy, because gross total resection is associated with a higher progression-free survival. Patients with residual tumour, progression of residual tumour or disease recurrence commonly require secondary surgery. We prospectively investigated the risk of postoperative speech impairment (POSI) and cranial nerve dysfunction (CND) following primary and secondary resection for posterior cranial fossa tumours. Methods In the Nordic-European study of the cerebellar mutism syndrome, we prospectively included children undergoing posterior fossa tumour resection or open biopsy in one of the 26 participating European centres. Neurological status was assessed preoperatively, and surgical details were noted post-operatively. Patients were followed up 2 weeks, 2 months and 1 year postoperatively. Here, we analyse the risk of postoperative speech impairment (POSI), defined as either mutism or reduced speech, and cranial nerve dysfunction (CND) following secondary, as compared to primary, surgery. Results We analysed 426 children undergoing primary and 78 undergoing secondary surgery between 2014 and 2020. The incidence of POSI was significantly lower after secondary (12%) compared with primary (28%, p = 0.0084) surgery. In a multivariate analysis adjusting for tumour histology, the odds ratio for developing POSI after secondary surgery was 0.23, compared with primary surgery (95% confidence interval: 0.08-0.65, p = 0.006). The frequency of postoperative CND did not differ significantly after primary vs. secondary surgery (p = 0.21). Conclusion Children have a lower risk of POSI after secondary than after primary surgery for posterior fossa tumours but remain at significant risk of both POSI and CND. The present findings should be taken in account when weighing risks and benefits of secondary surgery for posterior fossa tumours.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Cerebellar mutism syndrome
- Posterior fossa syndrome
- Secondary resection
- Posterior fossa tumour
- Cerebellar mutism syndrome
- Posterior fossa syndrome
- Posterior fossa tumour
- Secondary resection
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Gronbaek, J. Kja ...
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Toescu, S.
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Fric, R.
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Nilsson, Pelle
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Castor, C.
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Mallucci, C.
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visa fler...
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Pizer, B.
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Aquilina, K.
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Molinari, E.
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Hjort, M. Aasved
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Karppinen, A.
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Rutkauskiene, G.
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Mudra, K.
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Markia, B.
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van Baarsen, K.
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Hoving, E.
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Zipfel, J.
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Wibroe, M.
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Nysom, K.
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Schmiegelow, K.
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Sehested, A.
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Mathiasen, R.
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Juhler, M.
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Grønbæk, J. Kjær
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Child's Nervous ...
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Uppsala universitet
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