Bioactive Silicon Nitride Implant Surfaces with Maintained Antibacterial Properties

Silicon nitride (Si3N4) is a promising biomaterial, currently used in spinal fusion implants. Such implants should result in high vertebral union rates without major complications. However, pseudarthrosis remains an important complication that could lead to a need for implant replacement. Making silicon nitride implants more bioactive could lead to higher fusion rates, and reduce the incidence of pseudarthrosis. In this study, it was hypothesized that creating a highly negatively charged Si3N4 surface would enhance its bioactivity without affecting the antibacterial nature of the material. To this end, samples were thermally, chemically, and thermochemically treated. Apatite formation was examined for a 21-day immersion period as an in-vitro estimate of bioactivity. Staphylococcus aureus bacteria were inoculated on the surface of the samples, and their viability was investigated. It was found that the thermochemically and chemically treated samples exhibited enhanced bioactivity, as demonstrated by the increased spontaneous formation of apatite on their surface. All modified samples showed a reduction in the bacterial population; however, no statistically significant differences were noticed between groups. This study successfully demonstrated a simple method to improve the in vitro bioactivity of Si3N4 implants while maintaining the bacteriostatic properties.

Zhou, YijunUppsala universitet,Institutionen för materialvetenskap,Medicinsk teknik(Swepub:uu)yijzh368 (författare)
Welch, Ken,1968-Uppsala universitet,Nanoteknologi och funktionella material(Swepub:uu)kewel087 (författare)
Xia, Wei,Senior Lecture/Associate ProfessorUppsala universitet,Tillämpad materialvetenskap(Swepub:uu)weixi400 (författare)
Persson, CeciliaUppsala universitet,Institutionen för materialvetenskap,Medicinsk teknik(Swepub:uu)cecpe877 (författare)
Engqvist, Håkan,1972-Uppsala universitet,Tillämpad materialvetenskap(Swepub:uu)hakaengq (författare)
Uppsala universitetTillämpad materialvetenskap (creator_code:org_t)

Av författaren/redakt...: Katsaros, Ioanni ...; Zhou, Yijun; Welch, Ken, 1968 ...; Xia, Wei, Senior ...; Persson, Cecilia; Engqvist, Håkan, ...

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinsk biotek ...; och Biomaterialveten ...

TEKNIK OCH TEKNOLOGIER: TEKNIK OCH TEKNO ...; och Medicinteknik; och Medicinsk materi ...

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