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  • Thobani, Rozina S.Aga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)

Field evaluation of typhoid conjugate vaccine in a catch-up campaign among children aged 9 months to 15 years in Sindh, Pakistan

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-486664
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-486664URI
  • https://doi.org/10.1016/j.vaccine.2022.06.072DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Typhoid conjugate vaccine (TCV) has recently been introduced in the expanded program for immunization (EPI) in Pakistan. Before its introduction in routine immunization, a onetime catchup cam-paign among children 9 months to 15 years old was conducted in November 2019. We performed field evaluation of TCV against culture confirmed Salmonella Typhi (S. Typhi) among 9 months to 15 years old children during the catch up campaign in Karachi and Hyderabad.Methods: A rapid assessment of blood culture confirmed S. Typhi was performed. Age eligible cases of culture confirmed S. Typhi were identified from the laboratory networks of Aga Khan University Hospital Karachi and Hyderabad, Kharadar General Hospital Karachi, and Liaqat University of Medical & Health Sciences (LUMHS) Hyderabad. Information on sociodemographic, typhoid vaccination history and antimicrobial resistance was collected using a structured questionnaire.Patient medical records and lab reports were also reviewed to collect information on diagnosis and antimicrobial susceptibility information. Information about the population vaccination coverage during catch-up campaign was obtained from the provincial EPI office. Field performance of TCV in catchup cam-paign was measured by calculating the effectiveness using rapid screening method which is less resource-intensive technique of calculating vaccine effectiveness (VE). Results: Overall, 968 culture confirmed typhoid cases were enrolled. Among them, 82% (793/968) were from Karachi and 18% (175/968) from Hyderabad. The average age of the participants was 5.68 years, and 54% (523/968) were male. 6% (62/968) of the culture confirmed S. Typhi cases were multidrug resis-tant (MDR), and 61% (586/968) were extensively drug resistant (XDR). The VE using the TCV coverage data provided by EPI was 98%. Conclusion: TCV is effective against culture confirmed S. Typhi among children aged 9 months to 15 years in the catch-up campaign setting. While typhoid vaccination can significantly decrease the burden of typhoid disease, improvements in sanitation and hygiene are necessary for the prevention of spread of enteric fever. Longer term follow up will be needed to assess the duration of protection and requirement for booster doses of TCV.(c) 2022 Elsevier Ltd. All rights reserved.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Yousafzai, Mohammad TahirAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan.;Univ New South Wales, Kirby Inst, Level 6,Wallace Wurth Bldg,High St, Sydney, NSW 2052, Australia. (författare)
  • Sultana, ShaziaAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)
  • Kazi, Abdul MominAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)
  • Jan, MuhammadAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)
  • Rafey, AbdulAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)
  • Khan, AyubAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)
  • Irfan, SeemaAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)
  • Ujjan, Ikram UddinLiaquat Univ Med & Hlth Sci, C7JC 5GP, Jamshoro, Pakistan. (författare)
  • Brown, NickUppsala universitet,Internationell barnhälsa och nutrition(Swepub:uu)nicbr307 (författare)
  • Mårtensson, Andreas,1963-Uppsala universitet,Internationell barnhälsa och nutrition(Swepub:uu)andma331 (författare)
  • Qamar, Farah NazAga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan. (författare)
  • Aga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan.Aga Khan Univ Hosp, Dept Paediat & Child Hlth, Natl Stadium Rd, Karachi 74800, Sindh, Pakistan.;Univ New South Wales, Kirby Inst, Level 6,Wallace Wurth Bldg,High St, Sydney, NSW 2052, Australia. (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Vaccine: Elsevier40:36, s. 5391-53980264-410X1873-2518

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  • Vaccine (Sök värdpublikationen i LIBRIS)

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