Evolution of the ancestral mammalian karyotype and syntenic regions

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Sökning: WFRF:(Lewin P.) > (2020-2024) > Evolution of the an...

Evolution of the ancestral mammalian karyotype and syntenic regions

Damas, Joana (författare): The Genome Center, University of California, Davis, CA 95616

Corbo, Marco (författare): The Genome Center, University of California, Davis, CA 95616

Kim, Jaebum (författare): Department of Biomedical Science and Engineering, Konkuk University, Seoul 05029, South Korea

visa fler...

Turner-Maier, Jason (författare): Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142

Farré, Marta (författare): School of Biosciences, University of Kent, Canterbury CT2 7NJ, United Kingdom

Larkin, Denis M. (författare): The Royal Veterinary College, University of London, London NW1 0TU, United Kingdom

Ryder, Oliver A. (författare): Conservation Genetics, San Diego Zoo Wildlife Alliance, Escondido, CA 92027;Department of Evolution, Behavior, and Ecology, Division of Biology, University of California San Diego, La Jolla, CA 92093

Steiner, Cynthia (författare): Conservation Science Wildlife Health, San Diego Zoo Wildlife Alliance, Escondido, CA 92027

Houck, Marlys L. (författare): Beckman Center for Conservation Research, San Diego Zoo Wildlife Alliance, Escondido, CA 92027

Hall, Shaune (författare): Dovetail Genomics, LLC, Scotts Valley, CA 95066

Shiue, Lily (författare): Dovetail Genomics, LLC, Scotts Valley, CA 95066

Thomas, Stephen (författare): Dovetail Genomics, LLC, Scotts Valley, CA 95066

Swale, Thomas (författare): Dovetail Genomics, LLC, Scotts Valley, CA 95066

Daly, Mark (författare): Dovetail Genomics, LLC, Scotts Valley, CA 95066

Korlach, Jonas (författare): Pacific Biosciences, Menlo Park, CA 94025

Uliano-Silva, Marcela (författare): Wellcome Sanger Institute, Cambridgeshire CB10 1SA, United Kingdom;Berlin Center for Genomics in Biodiversity Research, D-14195 Berlin, Germany;Evolutionary Genetics Department, Leibniz Institut für Zoo- und Wildtierforschung, 10315 Berlin, Germany

Mazzoni, Camila J. (författare): Berlin Center for Genomics in Biodiversity Research, D-14195 Berlin, Germany;Evolutionary Genetics Department, Leibniz Institut für Zoo- und Wildtierforschung, 10315 Berlin, Germany

Birren, Bruce W. (författare): Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142

Genereux, Diane P. (författare): Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142

Johnson, Jeremy (författare): Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142

Lindblad-Toh, Kerstin (författare): Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab,Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142.

Karlsson, Elinor K. (författare): Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA 02142;Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01655;Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01655

Nweeia, Martin T. (författare): Department of Restorative Dentistry and Biomaterials Sciences, Harvard School of Dental Medicine, Boston, MA 02115;Department of Comprehensive Care, Case Western Reserve University School of Dental Medicine, Cleveland, OH 44106;Marine Mammal Program, Department of Vertebrate Zoology, Smithsonian Institution, Washington, DC 20002

Johnson, Rebecca N. (författare): Australian Museum Research Institute, Australian Museum, Sydney, NSW 2010, Australia;School of Life and Environmental Sciences, Faculty of Science, University of Sydney, Sydney, NSW 2006, Australia

Lewin, Harris A. (författare): The Genome Center, University of California, Davis, CA 95616;Department of Evolution and Ecology, University of California, Davis, CA 95616;John Muir Institute for the Environment, University of California, Davis, CA 95616

visa färre...

(creator_code:org_t)

2022-09-26
2022
Engelska.
Ingår i: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences (PNAS). - 0027-8424 .- 1091-6490. ; 119:40

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://uu.diva-port... (primary) (Raw object); https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Decrypting the rearrangements that drive mammalian chromosome evolution is critical to understanding the molecular bases of speciation, adaptation, and disease susceptibility. Using 8 scaffolded and 26 chromosome-scale genome assemblies representing 23/26 mammal orders, we computationally reconstructed ancestral karyotypes and syntenic relationships at 16 nodes along the mammalian phylogeny. Three different reference genomes (human, sloth, and cattle) representing phylogenetically distinct mammalian superorders were used to assess reference bias in the reconstructed ancestral karyotypes and to expand the number of clades with reconstructed genomes. The mammalian ancestor likely had 19 pairs of autosomes, with nine of the smallest chromosomes shared with the common ancestor of all amniotes (three still conserved in extant mammals), demonstrating a striking conservation of synteny for similar to 320My of vertebrate evolution. The numbers and types of chromosome rearrangements were classified for transitions between the ancestral mammalian karyotype, descendent ancestors, and extant species. For example, 94 inversions, 16 fissions, and 14 fusions that occurred over 53 My differentiated the therian from the descendent eutherian ancestor. The highest breakpoint rate was observed between the mammalian and therian ancestors (3.9 breakpoints/My). Reconstructed mammalian ancestor chromosomes were found to have distinct evolutionary histories reflected in their rates and types of rearrangements. The distributions of genes, repetitive elements, topologically associating domains, and actively transcribed regions in multispecies homologous synteny blocks and evolutionary breakpoint regions indicate that purifying selection acted over millions of years of vertebrate evolution to maintain syntenic relationships of developmentally important genes and regulatory landscapes of gene-dense chromosomes.

Hitta via bibliotek

Proceedings of the National Academy of Sciences of the United States of America (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Hitta mer i SwePub

Om ämnet

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Medicinsk geneti ...

Artiklar i publikationen: Proceedings of t ...

Av lärosätet: Uppsala universitet

Sök utanför SwePub

Sök vidare i:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se

Evolution of the ancestral mammalian karyotype and syntenic regions

Ämnesord

Publikations- och innehållstyp

Hitta via bibliotek

Till lärosätets databas

Hitta mer i SwePub

Sök utanför SwePub