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- Marwa, Karol J.Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania. (författare)
Lumefantrine plasma concentrations in uncontrolled conditions among patients treated with artemether-lumefantrine for uncomplicated plasmodium falciparum malaria in Mwanza, Tanzania
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
- Elsevier,2022
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-487234
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-487234URI
- https://doi.org/10.1016/j.ijid.2022.08.020DOI
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- Språk:engelska
- Sammanfattning på:engelska
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- Background: Therapeutic efficacy of artemether-lumefantrine is highly dependent on adequate systemic exposure to the partner drug lumefantrine particularly day 7 lumefantrine plasma concentration. There has been contradicting findings on the role of the cut-off values in predicting treatment outcomes among malaria patients in malaria endemic regions. This study assesses the day 3 and 7 lumefantrine plasma concentrations including related determinant factors and their influence on treatment outcomes among treated Tanzanian children and adults in uncontrolled conditions (real life condition).Methods: Data was nested from an efficacy study employing the WHO protocol, 2015 for monitoring antimalarial drug efficacy. Lumefantrine plasma concentration was measured by high performance liquid chromatography with ultraviolet (HPLC-UV).Results: Lumefantrine plasma concentrations below 175ng/ml and 20 0ng/ml on day 3 and 7 did not affect adequate clinical and parasitological response (ACPR) and recurrence of infection ( p = 0.428 and 0.239 respectively). Age and baseline parasitemia were not as-sociated to day 3 median lumefantrine plasma concentrations (p = 0.08 and 0.31 respectively) and day 7 lumefantrine plasma concentrations (p = 0.07 and 0.41 respectively). However, the day 3 and day 7 lumefantrine plasma concentrations were significantly higher in males compared to females ( p = 0.03 and 0.042 respectively).Conclusion: Lumefantrine plasma concentrations below cut-off points (175ng/ml and 20 0ng/ml) on day 3 and 7 did not influence treatment outcomes.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Medicinsk bioteknologi Medicinsk bioteknologi hsv//swe
- MEDICAL AND HEALTH SCIENCES Medical Biotechnology Medical Biotechnology hsv//eng
- Lumefantrine
- day 7 concentration
- day 3 concentration
- treatment outcomes and Tanzania
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Liwa, Anthony C.Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania. (författare)
- Konje, EvelineCatholic Univ Hlth & Allied Sci, Dept Epidemiol & Biostat, Mwanza, Tanzania. (författare)
- Mwita, StanleyCatholic Univ Hlth & Allied Sci, Sch Pharm, Mwanza, Tanzania. (författare)
- Kamugisha, ErasmusCatholic Univ Hlth & Allied Sci, Dept Biochem, Mwanza, Tanzania. (författare)
- Swedberg, GöteUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi(Swepub:uu)goteswed (författare)
- Catholic Univ Hlth & Allied Sci, Dept Pharmacol, Mwanza, Tanzania.Catholic Univ Hlth & Allied Sci, Dept Epidemiol & Biostat, Mwanza, Tanzania. (creator_code:org_t)
Sammanhörande titlar
- Ingår i:International Journal of Infectious Diseases: Elsevier123, s. 192-1991201-97121878-3511
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- International Journal of Infectious Diseases (Sök värdpublikationen i LIBRIS)
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- Av författaren/redakt...
- Marwa, Karol J.
- Liwa, Anthony C.
- Konje, Eveline
- Mwita, Stanley
- Kamugisha, Erasm ...
- Swedberg, Göte
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