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The Development of ...
The Development of Eletriptan Hydrobromide Immediate Release Buccal Films Using Central Composite Rotatable Design : An In Vivo and In Vitro Approach
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- Siddique, Waqar (författare)
- Univ Sargodha, Coll Pharm, Sargodha 40100, Pakistan.;Univ South Asia, Dept Pharm, Lahore 54000, Pakistan.
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- Zaman, Muhammad (författare)
- Univ Cent Punjab, Fac Pharm, Lahore 54000, Pakistan.
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- Sarfraz, Rai Muhammad (författare)
- Univ Sargodha, Coll Pharm, Sargodha 40100, Pakistan.
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- Hammad Butt, Muhammad (författare)
- Uppsala universitet,Institutionen för läkemedelskemi
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- Rehman, Atta Ur (författare)
- Forman Christian Coll, Dept Pharm, Lahore 54000, Pakistan.
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- Fassih, Noman (författare)
- Uppsala universitet,Institutionen för medicinsk cellbiologi
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- Albadrani, Ghadeer M. (författare)
- Princess Nourah Bint Abdulrahman Univ, Coll Sci, Dept Biol, POB 84428, Riyadh 11671, Saudi Arabia.
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- Bayram, Roula (författare)
- Batterjee Med Coll, Dept Pharmaceut Sci, Pharm Program, Jeddah 21442, Saudi Arabia.
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- Alfaifi, Mohammad Y. (författare)
- King Khalid Univ, Fac Sci, Biol Dept, Abha 9004, Saudi Arabia.
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- Abdel-Daim, Mohamed M. (författare)
- Batterjee Med Coll, Dept Pharmaceut Sci, Pharm Program, Jeddah 21442, Saudi Arabia.;Suez Canal Univ, Fac Vet Med, Pharmacol Dept, Ismailia 41522, Egypt.
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Univ Sargodha, Coll Pharm, Sargodha 40100, Pakistan;Univ South Asia, Dept Pharm, Lahore 54000, Pakistan. Univ Cent Punjab, Fac Pharm, Lahore 54000, Pakistan. (creator_code:org_t)
- 2022-09-23
- 2022
- Engelska.
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Ingår i: Polymers. - : MDPI. - 2073-4360. ; 14:19
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- The objective is to develop immediate release buccal films of Eletriptan Hydrobromide (EHBR) using hydroxypropyl methylcellulose (HPMC) E5. The buccal films have the ability to disintegrate rapidly and provide both systemic and local effects. The solvent casting method was employed to prepare the films and the central composite rotatable design (CCRD) model was used for film optimization. All the formulated films were characterized for physicochemical evaluation (Fourier transform infrared spectroscopy (FTIR), X-ray Diffraction (XRD), differential scanning calorimetry (DSC), and Scanning electron microscopy (SEM), in in-vitro, ex-vivo, and in-vivo drug release. The fabricated films were transparent, colorless, and evenly distributed. The FTIR spectra showed no chemical interaction between the drug and excipients. In in-vitro analysis, the film has the highest% drug release (102.61 +/- 1.13), while a maximum of 92.87 +/- 0.87% drug was diffused across the cellulose membrane having a pore size of 0.45 mu m. In the ex-vivo study, drug diffusion across the goat mucosa was performed and 80.9% of the drug was released in 30 min. In-vivo results depict a mean half-life (t1/2) of 4.54 +/- 0.18 h and a C-max of 128 +/- 0.87 (ng/mL); T-max was achieved in 1 h. Furthermore, instability and histopathological studies buccal films were proven to be safe and act as an effective dosage form. In a nutshell, optimized and safe instant release EHBR buccal films were prepared that have the tendency to provide effect effectively.
Ämnesord
- NATURVETENSKAP -- Kemi -- Polymerkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Polymer Chemistry (hsv//eng)
Nyckelord
- anti-migraine
- buccal films
- rapid onset
- oral cavity
- characterization
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Siddique, Waqar
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Zaman, Muhammad
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Sarfraz, Rai Muh ...
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Hammad Butt, Muh ...
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Rehman, Atta Ur
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Fassih, Noman
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Albadrani, Ghade ...
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Bayram, Roula
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Alfaifi, Mohamma ...
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Abdel-Daim, Moha ...
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- NATURVETENSKAP
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Polymers
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Uppsala universitet