Novel Benchmark Values for Redo Liver Transplantation Does the Outcome Justify the Effort?

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Novel Benchmark Values for Redo Liver Transplantation Does the Outcome Justify the Effort?

Abbassi, Fariba (författare): Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.

Gero, Daniel (författare): Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.

Muller, Xavier (författare): Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France.

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Bueno, Alba (författare): Kings Coll Hosp London, Inst Liver Studies, London, England.

Figiel, Wojciech (författare): Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Warsaw, Poland.

Robin, Fabien (författare): Univ Hosp Rennes, Dept HPB Surg & Transplantat, Rennes, France.

Laroche, Sophie (författare): Hop Paul Brousse, Hepatobiliary Ctr, Dept Surg & Transplantat, Villejuif, France.

Picard, Benjamin (författare): Hop Beaujon, APHP Nord, DMU PARABOL, Dept Anesthesiol Crit Care & Perioperat Med, Clichy, Nord, France.

Shankar, Sadhana (författare): Leeds Teaching Hosp trust, Dept Abdominal Transplant & Hepatobiliary Surg, Leeds, W Yorkshire, England.

Ivanics, Tommy (författare): Uppsala universitet,Gastrointestinalkirurgi,Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada.;Henry Ford Hosp, Dept Surg, Detroit, MI USA.

van Reeven, Marjolein (författare): Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.

van Leeuwen, Otto B. (författare): Univ Groningen, Univ Med Ctr Groningen, Div HPB Surg & Liver Transplantat, Groningen, Netherlands.

Braun, Hillary J. (författare): Univ Calif San Francisco, Div Transplant Surg, San Francisco, CA USA.

Monbaliu, Diethard (författare): Univ Hosp Leuven, Dept Abdominal Transplant Surg & Transplant Coord, Leuven, Belgium.

Breton, Antoine (författare): Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France.

Vachharajani, Neeta (författare): Washington Univ, St Louis Sch Med, Div Abdominal Transplantat, Dept Surg, St Louis, MO USA.

Bonaccorsi Riani, Eliano (författare): Univ Hosp St Luc, Dept Abdominal & Transplant Surg, Brussels, Belgium.

Nowak, Greg (författare): Karolinska Univ, Hosp Huddinge, Dept Transplantat Surg, Stockholm, Sweden.

McMillan, Robert R. (författare): Houston Methodist Hosp, Weill Cornell Med Ctr, Houston, TX USA.

Abu-Gazala, Samir (författare): Hosp Univ Penn, Penn Transplant Inst, Dept Surg, Philadelphia, PA USA.

Nair, Amit (författare): Univ Rochester, Div Transplantat & Hepatobiliary Surg, Rochester, MN USA.

Bruballa, Rocio (författare): Hosp Italiano Buenos Aires, HPB & Liver Transplant Unit, Buenos Aires, Argentina.

Paterno, Flavio (författare): Univ Hosp, Rutgers New Jersey Med Sch, Div Liver Transplant, Newark, NJ USA.

Weppler Sears, Deborah (författare): Cleveland Clin Florida, Dept Abdominal & Transplant Surg, Weston, FL USA.

Pinna, Antonio D. (författare): Cleveland Clin Florida, Dept Abdominal & Transplant Surg, Weston, FL USA.

Guarrera, James V. (författare): Univ Hosp, Rutgers New Jersey Med Sch, Div Liver Transplant, Newark, NJ USA.

de Santibanes, Eduardo (författare): Hosp Italiano Buenos Aires, HPB & Liver Transplant Unit, Buenos Aires, Argentina.

de Santibanes, Martin (författare): Hosp Italiano Buenos Aires, HPB & Liver Transplant Unit, Buenos Aires, Argentina.

Hernandez-Alejandro, Roberto (författare): Univ Rochester, Div Transplantat & Hepatobiliary Surg, Rochester, MN USA.

Olthoff, Kim (författare): Hosp Univ Penn, Penn Transplant Inst, Dept Surg, Philadelphia, PA USA.

Ghobrial, R. Mark (författare): Houston Methodist Hosp, Weill Cornell Med Ctr, Houston, TX USA.

Ericzon, Bo-Goran (författare): Karolinska Institutet

Ciccarelli, Olga (författare): Univ Hosp St Luc, Dept Abdominal & Transplant Surg, Brussels, Belgium.

Chapman, William C. (författare): Washington Univ, St Louis Sch Med, Div Abdominal Transplantat, Dept Surg, St Louis, MO USA.

Mabrut, Jean-Yves (författare): Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France.

Pirenne, Jacques (författare): Univ Hosp Leuven, Dept Abdominal Transplant Surg & Transplant Coord, Leuven, Belgium.

Mullhaupt, Beat (författare): Univ Hosp Zurich, Dept Gastroenterol & Hepatol, Zurich, Switzerland.

Ascher, Nancy L. (författare): Univ Calif San Francisco, Div Transplant Surg, San Francisco, CA USA.

Porte, Robert J. (författare): Univ Groningen, Univ Med Ctr Groningen, Div HPB Surg & Liver Transplantat, Groningen, Netherlands.

de Meijer, Vincent E. (författare): Univ Groningen, Univ Med Ctr Groningen, Div HPB Surg & Liver Transplantat, Groningen, Netherlands.

Polak, Wojciech G. (författare): Univ Med Ctr Rotterdam, Erasmus MC Transplant Inst, Dept Surg, Div HPB & Transplant Surg, Rotterdam, Netherlands.

Sapisochin, Gonzalo (författare): Univ Toronto, Univ Hlth Network, Multiorgan Transplant Program, Toronto, ON, Canada.

Attia, Magdy (författare): Leeds Teaching Hosp trust, Dept Abdominal Transplant & Hepatobiliary Surg, Leeds, W Yorkshire, England.

Soubrane, Olivier (författare): Hop Beaujon, APHP Nord, DMU DIGEST, Dept HPB Surg & Liver Transplantat, Clichy, France.

Weiss, Emmanuel (författare): Hop Beaujon, APHP Nord, DMU PARABOL, Dept Anesthesiol Crit Care & Perioperat Med, Clichy, Nord, France.

Adam, Rene A. (författare): Hop Paul Brousse, Hepatobiliary Ctr, Dept Surg & Transplantat, Villejuif, France.

Cherqui, Daniel (författare): Hop Paul Brousse, Hepatobiliary Ctr, Dept Surg & Transplantat, Villejuif, France.

Boudjema, Karim (författare): Univ Hosp Rennes, Dept HPB Surg & Transplantat, Rennes, France.

Zieniewicz, Krzysztof (författare): Med Univ Warsaw, Dept Gen Transplant & Liver Surg, Warsaw, Poland.

Jassem, Wayel (författare): Kings Coll Hosp London, Inst Liver Studies, London, England.

Dutkowski, Philipp (författare): Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.

Clavien, Pierre-Alain (författare): Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland.

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Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland Croix Rousse Hosp, Dept Gen Abdominal & Transplant Surg, Lyon, France. (creator_code:org_t)

Lippincott Williams & Wilkins, 2022
2022
Engelska.
Ingår i: Annals of Surgery. - : Lippincott Williams & Wilkins. - 0003-4932 .- 1528-1140. ; 276:5, s. 860-867

Relaterad länk:: https://urn.kb.se/re...; visa fler...; https://doi.org/10.1...; http://kipublication...; visa färre...

Tidskriftsartikel (refereegranskat)

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Objective: To define benchmark cutoffs for redo liver transplantation (redo-LT). Background: In the era of organ shortage, redo-LT is frequently discussed in terms of expected poor outcome and wasteful resources. However, there is a lack of benchmark data to reliably evaluate outcomes after redo-LT. Methods: We collected data on redo-LT between January 2010 and December 2018 from 22 high-volume transplant centers. Benchmark cases were defined as recipients with model of end stage liver disease (MELD) score <= 25, absence of portal vein thrombosis, no mechanical ventilation at the time of surgery, receiving a graft from a donor after brain death. Also, high-urgent priority and early redo-LT including those for primary nonfunction (PNF) or hepatic artery thrombosis were excluded. Benchmark cutoffs were derived from the 75th percentile of the medians of all benchmark centers. Results: Of 1110 redo-LT, 373 (34%) cases qualified as benchmark cases. Among these cases, the rate of postoperative complications until discharge was 76%, and increased up to 87% at 1-year, respectively. One-year overall survival rate was excellent with 90%. Benchmark cutoffs included Comprehensive Complication Index CCI (R) at 1-year of <= 72, and in-hospital and 1-year mortality rates of <= 13% and <= 15%, respectively. In contrast, patients who received a redo-LT for PNF showed worse outcomes with some values dramatically outside the redoLT benchmarks. Conclusion: This study shows that redo-LT achieves good outcome when looking at benchmark scenarios. However, this figure changes in high-risk redo-LT, as for example in PNF. This analysis objectifies for the first-time results and efforts for redo-LT and can serve as a basis for discussion about the use of scarce resources.

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Av författaren/redakt...: Abbassi, Fariba; Gero, Daniel; Muller, Xavier; Bueno, Alba; Figiel, Wojciech; Robin, Fabien; visa fler...; Laroche, Sophie; Picard, Benjamin; Shankar, Sadhana; Ivanics, Tommy; van Reeven, Marj ...; van Leeuwen, Ott ...; Braun, Hillary J ...; Monbaliu, Dietha ...; Breton, Antoine; Vachharajani, Ne ...; Bonaccorsi Riani ...; Nowak, Greg; McMillan, Robert ...; Abu-Gazala, Sami ...; Nair, Amit; Bruballa, Rocio; Paterno, Flavio; Weppler Sears, D ...; Pinna, Antonio D ...; Guarrera, James ...; de Santibanes, E ...; de Santibanes, M ...; Hernandez-Alejan ...; Olthoff, Kim; Ghobrial, R. Mar ...; Ericzon, Bo-Gora ...; Ciccarelli, Olga; Chapman, William ...; Mabrut, Jean-Yve ...; Pirenne, Jacques; Mullhaupt, Beat; Ascher, Nancy L.; Porte, Robert J.; de Meijer, Vince ...; Polak, Wojciech ...; Sapisochin, Gonz ...; Attia, Magdy; Soubrane, Olivie ...; Weiss, Emmanuel; Adam, Rene A.; Cherqui, Daniel; Boudjema, Karim; Zieniewicz, Krzy ...; Jassem, Wayel; Dutkowski, Phili ...; Clavien, Pierre- ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kardiologi

Artiklar i publikationen: Annals of Surger ...

Av lärosätet: Uppsala universitet; Karolinska Institutet

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Novel Benchmark Values for Redo Liver Transplantation Does the Outcome Justify the Effort?

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