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Search: L773:0939 6411 OR L773:1873 3441 > (2020-2024) > Effect of fluid vel...

  • Andersson, Sara B. E.Uppsala universitet,Institutionen för farmaceutisk biovetenskap (author)

Effect of fluid velocity and particle size on the hydrodynamic diffusion layer thickness

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Elsevier,2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-488230
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-488230URI
  • https://doi.org/10.1016/j.ejpb.2022.09.016DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • The aim of this study was to determine the thickness of the hydrodynamic diffusion layer (h(HDL)) of three poor water-soluble compounds under laminar fluid flow using a single particle dissolution technique. The single particle dissolution experiments were performed in a flowing aqueous medium using four different fluid velocities (v), ranging from 46 to 103 mm/s. The particles used had an initial radius (r) of 18.8 to 52.3 mu m. The determined h(HDL) values were calculated from both dissolution experiments and computational fluid dynamics (CFD) simulation. In this study, single particle dissolution experiments gave, with one exception, h(HDL) values in the range of 2.09 to 8.85 mu m and corresponding simulations gave h(HDL) values in the range of 2.53 to 4.38 mu m. Hence, we found a semi-quantitative concordance between experimental and simulated determined h(HDL) values. Also, a theoretical relation between the dependence of hHDL on particle radius and flow velocity of the medium was established by a series of CFD simulations in a fluid velocity range of 10-100 mm/s and particle size (radius) range of 5-40 mu m. The outcome suggests a power law relation of the form h(HDL)alpha r(3/5)v(-2/5). In addition, the h(HDL) seems to be independent of the solubility, while it has a diffusion coefficient dependence. In conclusion, the hHDL values were determined under well-defined conditions; hence, this approach can be used to estimate the h(HDL) under different conditions to increase the understanding of the mass transfer mechanisms during the dissolution process.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Frenning, GöranUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)gfr09426 (author)
  • Alderborn, GöranUppsala universitet,Institutionen för farmaceutisk biovetenskap(Swepub:uu)gal29049 (author)
  • Gråsjö, Johan,1962-Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Institutionen för läkemedelskemi(Swepub:uu)jgr13120 (author)
  • Uppsala universitetInstitutionen för farmaceutisk biovetenskap (creator_code:org_t)

Related titles

  • In:European journal of pharmaceutics and biopharmaceutics: Elsevier180, s. 1-100939-64111873-3441

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Andersson, Sara ...
Frenning, Göran
Alderborn, Göran
Gråsjö, Johan, 1 ...
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NATURAL SCIENCES
NATURAL SCIENCES
and Biological Scien ...
and Biophysics
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European journal ...
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Uppsala University

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