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Association of Arte...
Abstract
Ämnesord
Stäng
- Background In this study, the association of the arterial content of oxygen, carbon dioxide, glucose, and lactate with cerebral pressure reactivity, energy metabolism and clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH) was investigated.Methods In this retrospective study, 60 patients with aSAH, treated at the neurointensive care (NIC), Uppsala University Hospital, Sweden, between 2016 and 2021 with arterial blood gas (ABG), intracranial pressure, and cerebral microdialysis (MD) monitoring were included. The first 10 days were divided into an early phase (day 1 to 3) and a vasospasm phase (day 4 to 10).Results Higher arterial lactate was independently associated with higher/worse pressure reactivity index (PRx) in the early phase (beta = 0.32, P = .02), whereas higher pO(2) had the opposite association in the vasospasm phase (beta = -0.30, P = .04). Arterial glucose and pCO(2) were not associated with PRx. Higher arterial lactate (beta = 0.29, P = .05) was independently associated with higher MD-glucose in the vasospasm phase, whereas higher pO(2) had the opposite association in the vasospasm phase (beta = -0.33, P = .03). Arterial glucose and pCO(2) were not associated with MD-glucose. Higher pCO(2) in the early phase, lower arterial glucose in both phases, and lower arterial lactate in the vasospasm phase were associated (P < .05) with better clinical outcome.Conclusions Arterial variables associated with more vasoconstriction (higher pO(2) and lower arterial lactate) were associated with better cerebral pressure reactivity, but worse energy metabolism. In severe aSAH, when cerebral large-vessel vasospasm with exhausted distal vasodilation is common, more vasoconstriction could increase distal vasodilatory reserve and pressure reactivity, but also reduce cerebral blood flow and metabolic supply. The MD may be useful to monitor the net effects on cerebral metabolism in PRx-targeted NIC.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- aneurysmal subarachnoid hemorrhage
- arterial blood gas
- cerebral microdialysis
- cerebral pressure reactivity
- neurointensive care
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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