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Additive and Multip...
Additive and Multiplicative Interactions Between Genetic Risk Score and Family History and Lifestyle in Relation to Risk of Type 2 Diabetes
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Ding, Ming (författare)
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- Ahmad, Shafqat (författare)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA;Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA
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Qi, Lu (författare)
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Hu, Yang (författare)
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Bhupathiraju, Shilpa N (författare)
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Guasch-Ferré, Marta (författare)
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Jensen, Majken K (författare)
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Chavarro, Jorge E (författare)
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Ridker, Paul M (författare)
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Willett, Walter C (författare)
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Chasman, Daniel I (författare)
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Hu, Frank B (författare)
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Kraft, Peter (författare)
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Department of Nutrition, Harvard TH. Chan School of Public Health, Boston, Massachusetts, USA;Division of Preventive Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA (creator_code:org_t)
- 2019-10-24
- 2020
- Engelska.
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Ingår i: American Journal of Epidemiology. - : Oxford University Press. - 0002-9262 .- 1476-6256. ; 189:5, s. 445-460
- Relaterad länk:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- We examined interactions between lifestyle factors and genetic risk of type 2 diabetes (T2D-GR), captured by genetic risk score (GRS) and family history (FH). Our initial study cohort included 20,524 European-ancestry participants, of whom 1,897 developed incident T2D, in the Nurses' Health Study (1984-2016), Nurses' Health Study II (1989-2016), and Health Professionals Follow-up Study (1986-2016). The analyses were replicated in 19,183 European-ancestry controls and 2,850 incident T2D cases in the Women's Genome Health Study (1992-2016). We defined 2 categories of T2D-GR: high GRS (upper one-third) with FH and low GRS or without FH. Compared with participants with the healthiest lifestyle and low T2D-GR, the relative risk of T2D for participants with the healthiest lifestyle and high T2D-GR was 2.24 (95% confidence interval (CI): 1.76, 2.86); for participants with the least healthy lifestyle and low T2D-GR, it was 4.05 (95% CI: 3.56, 4.62); and for participants with the least healthy lifestyle and high T2D-GR, it was 8.72 (95% CI: 7.46, 10.19). We found a significant departure from an additive risk difference model in both the initial and replication cohorts, suggesting that adherence to a healthy lifestyle could lead to greater absolute risk reduction among those with high T2D-GR. The public health implication is that a healthy lifestyle is important for diabetes prevention, especially for individuals with high GRS and FH of T2D.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Medicinsk vetenskap
- Medical Science
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- Av författaren/redakt...
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Ding, Ming
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Ahmad, Shafqat
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Qi, Lu
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Hu, Yang
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Bhupathiraju, Sh ...
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Guasch-Ferré, Ma ...
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visa fler...
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Jensen, Majken K
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Chavarro, Jorge ...
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Ridker, Paul M
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Willett, Walter ...
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Chasman, Daniel ...
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Hu, Frank B
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Kraft, Peter
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visa färre...
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