Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study

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Dixon-Suen, Suzanne CCancer Council Victoria (author)

Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study

Article/chapterEnglish2022

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2022-09-06
BMJ Publishing Group Ltd,2022
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LIBRIS-ID:oai:DiVA.org:uu-489540
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489540URI
https://doi.org/10.1136/bjsports-2021-105132DOI
http://kipublications.ki.se/Default.aspx?queryparsed=id:150459871URI
https://lup.lub.lu.se/record/33b1be06-6bf7-43ac-a73c-1357fab4e5bfURI

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Language:English
Summary in:English

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SwePubSwePub

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Subject category:ref swepub-contenttype
Subject category:art swepub-publicationtype

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OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity.RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Cancer och onkologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cancer and Oncology hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Health Sciences Public Health, Global Health, Social Medicine and Epidemiology hsv//eng
Breast
Genetics
Physical activity
Sedentary Behaviour

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Lewis, Sarah J (author)
Martin, Richard M (author)
English, Dallas R (author)
Boyle, Terry (author)
Giles, Graham G (author)
Michailidou, Kyriaki (author)
Bolla, Manjeet K (author)
Wang, Qin (author)
Dennis, Joe (author)
Lush, Michael (author)
Investigators, Abctb (author)
Ahearn, Thomas U (author)
Ambrosone, Christine B (author)
Andrulis, Irene LKarolinska Institutet (author)
Anton-Culver, Hoda (author)
Arndt, Volker (author)
Aronson, Kristan J (author)
Augustinsson, A.Lund University,Lunds universitet,Karolinska Institutet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Cancerepidemiologi & strål,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Biomarkörer och Epi,Institutionen för kliniska vetenskaper, Lund,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Cancerepidemiology and radiation,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Biomarkers and epidemiology,Department of Clinical Sciences, Lund(Swepub:lu)med-aea (author)
Auvinen, Päivi (author)
Beane Freeman, Laura E (author)
Becher, Heiko (author)
Beckmann, Matthias W (author)
Behrens, Sabine (author)
Bermisheva, MarinaUniversity of Melbourne,Cancer Council Victoria (author)
Blomqvist, Carl (author)
Bogdanova, Natalia V (author)
Bojesen, Stig E (author)
Bonanni, Bernardo (author)
Brenner, Hermann (author)
Brüning, Thomas (author)
Buys, Saundra S (author)
Camp, Nicola J (author)
Campa, Daniele (author)
Canzian, Federico (author)
Castelao, Jose E (author)
Cessna, Melissa H (author)
Chang-Claude, Jenny (author)
Chanock, Stephen J (author)
Clarke, Christine L (author)
Conroy, Don M (author)
Couch, Fergus J (author)
Cox, Angela (author)
Cross, Simon S (author)
Czene, KamilaKarolinska Institutet (author)
Daly, Mary B (author)
Devilee, Peter (author)
Dörk, Thilo (author)
Dwek, Miriam (author)
Eccles, Diana M (author)
Eliassen, A Heather (author)
Engel, Christoph (author)
Eriksson, MikaelKarolinska Institutet (author)
Evans, D Gareth (author)
Fasching, Peter A (author)
Fletcher, Olivia (author)
Flyger, Henrik (author)
Fritschi, Lin (author)
Gabrielson, MarikeKarolinska Institutet (author)
Gago-Dominguez, Manuela (author)
García-Closas, Montserrat (author)
García-Sáenz, José A (author)
Goldberg, Mark S (author)
Guénel, Pascal (author)
Gündert, Melanie (author)
Hahnen, Eric (author)
Haiman, Christopher A (author)
Häberle, Lothar (author)
Håkansson, NiclasKarolinska Institutet (author)
Hall, PerKarolinska Institutet (author)
Hamann, Ute (author)
Hart, Steven N (author)
Harvie, Michelle (author)
Hillemanns, Peter (author)
Hollestelle, Antoinette (author)
Hooning, Maartje J (author)
Hoppe, Reiner (author)
Hopper, John (author)
Howell, Anthony (author)
Hunter, David J (author)
Jakubowska, Anna (author)
Janni, Wolfgang (author)
John, Esther M (author)
Jung, Audrey (author)
Kaaks, Rudolf (author)
Keeman, Renske (author)
Kitahara, Cari M (author)
Koutros, Stella (author)
Kraft, Peter (author)
Kristensen, Vessela N (author)
Kubelka-Sabit, Katerina (author)
Kurian, Allison W (author)
Lacey, James V (author)
Lambrechts, Diether (author)
Le Marchand, Loic (author)
Lindblom, Annika (author)
Loibl, Sibylle (author)
Lubiński, Jan (author)
Mannermaa, Arto (author)
Manoochehri, Mehdi (author)
Margolin, SaraKarolinska Institutet (author)
Martinez, Maria Elena (author)
Mavroudis, Dimitrios (author)
Menon, Usha (author)
Mulligan, Anna Marie (author)
Murphy, Rachel A (author)
Collaborators, Nbcs (author)
Nevanlinna, Heli (author)
Nevelsteen, Ines (author)
Newman, William G (author)
Offit, Kenneth (author)
Olshan, Andrew F (author)
Olsson, H.Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Biomarkörer och Epi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lund Melanoma Study Group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Biomarkers and epidemiology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onk-hol (author)
Orr, Nick (author)
Patel, Alpa (author)
Peto, Julian (author)
Plaseska-Karanfilska, Dijana (author)
Presneau, Nadege (author)
Rack, Brigitte (author)
Radice, Paolo (author)
Rees-Punia, Erika (author)
Rennert, Gad (author)
Rennert, Hedy S (author)
Romero, Atocha (author)
Saloustros, Emmanouil (author)
Sandler, Dale P (author)
Schmidt, Marjanka K (author)
Schmutzler, Rita K (author)
Schwentner, Lukas (author)
Scott, Christopher (author)
Shah, Mitul (author)
Shu, Xiao-Ou (author)
Simard, Jacques (author)
Southey, Melissa C (author)
Stone, Jennifer (author)
Surowy, Harald (author)
Swerdlow, Anthony J (author)
Tamimi, Rulla M (author)
Tapper, William J (author)
Taylor, Jack A (author)
Terry, Mary Beth (author)
Tollenaar, Rob A E M (author)
Troester, Melissa A (author)
Truong, Thérèse (author)
Untch, Michael (author)
Vachon, Celine M (author)
Joseph, Vijai (author)
Wappenschmidt, Barbara (author)
Weinberg, Clarice R (author)
Wolk, AlicjaUppsala universitet,Medicinsk epidemiologi,Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:uu)alwol516 (author)
Yannoukakos, Drakoulis (author)
Zheng, Wei (author)
Ziogas, Argyrios (author)
Dunning, Alison M (author)
Pharoah, Paul D P (author)
Easton, Douglas F (author)
Milne, Roger L (author)
Lynch, Brigid M (author)
Karolinska InstitutetCancer Council Victoria (creator_code:org_t)
Breast Cancer Association Consortium

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By the author/editor: Dixon-Suen, Suza ...; Lewis, Sarah J; Martin, Richard ...; English, Dallas ...; Boyle, Terry; Giles, Graham G; show more...; Michailidou, Kyr ...; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Lush, Michael; Investigators, A ...; Ahearn, Thomas U; Ambrosone, Chris ...; Andrulis, Irene ...; Anton-Culver, Ho ...; Arndt, Volker; Aronson, Kristan ...; Augustinsson, A.; Auvinen, Päivi; Beane Freeman, L ...; Becher, Heiko; Beckmann, Matthi ...; Behrens, Sabine; Bermisheva, Mari ...; Blomqvist, Carl; Bogdanova, Natal ...; Bojesen, Stig E; Bonanni, Bernard ...; Brenner, Hermann; Brüning, Thomas; Buys, Saundra S; Camp, Nicola J; Campa, Daniele; Canzian, Federic ...; Castelao, Jose E; Cessna, Melissa ...; Chang-Claude, Je ...; Chanock, Stephen ...; Clarke, Christin ...; Conroy, Don M; Couch, Fergus J; Cox, Angela; Cross, Simon S; Czene, Kamila; Daly, Mary B; Devilee, Peter; Dörk, Thilo; Dwek, Miriam; Eccles, Diana M; Eliassen, A Heat ...; Engel, Christoph; Eriksson, Mikael; Evans, D Gareth; Fasching, Peter ...; Fletcher, Olivia; Flyger, Henrik; Fritschi, Lin; Gabrielson, Mari ...; Gago-Dominguez, ...; García-Closas, M ...; García-Sáenz, Jo ...; Goldberg, Mark S; Guénel, Pascal; Gündert, Melanie; Hahnen, Eric; Haiman, Christop ...; Häberle, Lothar; Håkansson, Nicla ...; Hall, Per; Hamann, Ute; Hart, Steven N; Harvie, Michelle; Hillemanns, Pete ...; Hollestelle, Ant ...; Hooning, Maartje ...; Hoppe, Reiner; Hopper, John; Howell, Anthony; Hunter, David J; Jakubowska, Anna; Janni, Wolfgang; John, Esther M; Jung, Audrey; Kaaks, Rudolf; Keeman, Renske; Kitahara, Cari M; Koutros, Stella; Kraft, Peter; Kristensen, Vess ...; Kubelka-Sabit, K ...; Kurian, Allison ...; Lacey, James V; Lambrechts, Diet ...; Le Marchand, Loi ...; Lindblom, Annika; Loibl, Sibylle; Lubiński, Jan; Mannermaa, Arto; Manoochehri, Meh ...; Margolin, Sara; Martinez, Maria ...; Mavroudis, Dimit ...; Menon, Usha; Mulligan, Anna M ...; Murphy, Rachel A; Collaborators, N ...; Nevanlinna, Heli; Nevelsteen, Ines; Newman, William ...; Offit, Kenneth; Olshan, Andrew F; Olsson, H.; Orr, Nick; Patel, Alpa; Peto, Julian; Plaseska-Karanfi ...; Presneau, Nadege; Rack, Brigitte; Radice, Paolo; Rees-Punia, Erik ...; Rennert, Gad; Rennert, Hedy S; Romero, Atocha; Saloustros, Emma ...; Sandler, Dale P; Schmidt, Marjank ...; Schmutzler, Rita ...; Schwentner, Luka ...; Scott, Christoph ...; Shah, Mitul; Shu, Xiao-Ou; Simard, Jacques; Southey, Melissa ...; Stone, Jennifer; Surowy, Harald; Swerdlow, Anthon ...; Tamimi, Rulla M; Tapper, William ...; Taylor, Jack A; Terry, Mary Beth; Tollenaar, Rob A ...; Troester, Meliss ...; Truong, Thérèse; Untch, Michael; Vachon, Celine M; Joseph, Vijai; Wappenschmidt, B ...; Weinberg, Claric ...; Wolk, Alicja; Yannoukakos, Dra ...; Zheng, Wei; Ziogas, Argyrios; Dunning, Alison ...; Pharoah, Paul D ...; Easton, Douglas ...; Milne, Roger L; Lynch, Brigid M; show less...

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