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  • Batra, GoravUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Sweden; Uppsala Univ, Sweden (författare)

Biomarker-Based Prediction of Recurrent Ischemic Events in Patients With Acute Coronary Syndromes

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • Elsevier,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-489594
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489594URI
  • https://doi.org/10.1016/j.jacc.2022.08.767DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190216URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • BACKGROUND: In patients with acute coronary syndrome (ACS), there is residual and variable risk of recurrent ischemic events.OBJECTIVES: This study aimed to develop biomarker-based prediction models for 1-year risk of cardiovascular (CV) death and myocardial infarction (MI) in patients with ACS undergoing percutaneous coronary intervention.METHODS: We included 10,713 patients from the PLATO (A Comparison of Ticagrelor [AZD6140] and Clopidogrel in Patients With Acute Coronary Syndrome) trial in the development cohort and externally validated in 3,508 patients from the TRACER (Thrombin Receptor Antagonist for Clinical Event Reduction in Acute Coronary Syndrome) trial. Variables contributing to risk of CV death/MI were assessed using Cox regression models, and a score was derived using subsets of variables approximating the full model.RESULTS: There were 632 and 190 episodes of CV death/MI in the development and validation cohorts. The most important predictors of CV death/MI were the biomarkers, growth differentiation factor 15, and N-terminal pro-B-type natriuretic peptide, which had greater prognostic value than all candidate variables. The final model included 8 items: age (A), biomarkers (B) (growth differentiation factor 15 and N-terminal pro-B-type natriuretic peptide), and clinical variables (C) (extent of coronary artery disease, previous vascular disease, Killip class, ACS type, P2Y12 inhibitor). The model, named ABC-ACS ischemia, was well calibrated and showed good discriminatory ability for 1-year risk of CV death/MI with C-indices of 0.71 and 0.72 in the development and validation cohorts, respectively. For CV death, the score performed better, with C-indices of 0.80 and 0.84 in the development and validation cohorts, respectively.CONCLUSIONS: An 8-item score for the prediction of CV death/MI was developed and validated for patients with ACS undergoing percutaneous coronary intervention. The ABC-ACS ischemia score showed good calibration and discrimination and might be useful for risk prediction and decision support in patients with ACS. (A Comparison of Ticagrelor [AZD6140] and Clopidogrel in Patients With Acute Coronary Syndrome [PLATO]; NCT00391872; Trial to Assess the Effects of Vorapaxar [SCH 530348; MK-5348] in Preventing Heart Attack and Stroke in Participants With Acute Coronary Syndrome [TRACER]; NCT00527943)

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lindbäck, JohanUppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden(Swepub:uu)jolin255 (författare)
  • Becker, Richard C.Univ Cincinnati, Coll Med, Div Cardiovasc Hlth & Dis, Heart Lung & Vasc Inst, Cincinnati, OH USA. (författare)
  • Harrington, Robert A.Stanford Univ, Dept Med, Stanford, CA USA. (författare)
  • Held, Claes,1956-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala Univ, Sweden; Uppsala Univ, Sweden(Swepub:uu)clahe947 (författare)
  • James, Stefan,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden; Uppsala Univ, Sweden(Swepub:uu)stjam367 (författare)
  • Kempf, TiborHannover Med Sch, Div Mol & Translat Cardiol, Dept Cardiol & Angiol, Hannover, Germany. (författare)
  • Lopes, Renato D.Duke Univ, Med Ctr, Dept Med, Div Cardiol,Duke Clin Res Inst, Durham, NC USA. (författare)
  • Mahaffey, Kenneth W.Stanford Univ, Stanford Ctr Clin Res, Dept Med, Stanford, CA USA. (författare)
  • Steg, Philippe GabrielUniv Paris, Hop Bichat, Assistance Publ Hop Paris, Inst Natl Sante & Rech Med,Unite 1148, Paris, France. (författare)
  • Storey, Robert F.Univ Sheffield, Dept Infect Immun & Cardiovasc Dis, Sheffield, England. (författare)
  • Swahn, EvaLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US(Swepub:liu)evasw45 (författare)
  • Wollert, Kai C.Hannover Med Sch, Div Mol & Translat Cardiol, Dept Cardiol & Angiol, Hannover, Germany. (författare)
  • Siegbahn, Agneta,1947-Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk kemi,Uppsala Univ, Sweden; Uppsala Univ, Sweden(Swepub:uu)agsie424 (författare)
  • Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala Univ, Sweden; Uppsala Univ, Sweden(Swepub:uu)larswall (författare)
  • Uppsala universitetUppsala kliniska forskningscentrum (UCR) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of the American College of Cardiology: Elsevier80:18, s. 1735-17470735-10971558-3597

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