Sökning: id:"swepub:oai:DiVA.org:uu-489605" >
An International Mu...
-
Elliott, Jessie A
(författare)
An International Multicenter Study Exploring Whether Surveillance After Esophageal Cancer Surgery Impacts Oncological and Quality of Life Outcomes (ENSURE).
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
-
2022
-
2022
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:uu-489605
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489605URI
-
https://doi.org/10.1097/SLA.0000000000005378DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:152893760URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
OBJECTIVE: To determine the impact of surveillance on recurrence pattern, treatment, survival and health-related quality-of-life (HRQL) following curative-intent resection for esophageal cancer.SUMMARY BACKGROUND DATA: Although therapies for recurrent esophageal cancer may impact survival and HRQL, surveillance protocols after primary curative treatment are varied and inconsistent, reflecting a lack of evidence.METHODS: European iNvestigation of SUrveillance after Resection for Esophageal cancer was an international multicenter study of consecutive patients undergoing surgery for esophageal and esophagogastric junction cancers (2009-2015) across 20 centers (NCT03461341). Intensive surveillance (IS) was defined as annual computed tomography for 3 years postoperatively. The primary outcome measure was overall survival (OS), secondary outcomes included treatment, disease-specific survival, recurrence pattern, and HRQL. Multivariable linear, logistic, and Cox proportional hazards regression analyses were performed.RESULTS: Four thousand six hundred eighty-two patients were studied (72.6% adenocarcinoma, 69.1% neoadjuvant therapy, 45.5% IS). At median followup 60 months, 47.5% developed recurrence, oligometastatic in 39%. IS was associated with reduced symptomatic recurrence (OR 0.17 [0.12-0.25]) and increased tumor-directed therapy (OR 2.09 [1.58-2.77]). After adjusting for confounders, no OS benefit was observed among all patients (HR 1.01 [0.89-1.13]), but OS was improved following IS for those who underwent surgery alone (HR 0.60 [0.47-0.78]) and those with lower pathological (y)pT stages (Tis-2, HR 0.72 [0.58-0.89]). IS was associated with greater anxiety ( P =0.016), but similar overall HRQL.CONCLUSIONS: IS was associated with improved oncologic outcome in select cohorts, specifically patients with early-stage disease at presentation or favorable pathological stage post neoadjuvant therapy. This may inform guideline development, and enhance shared decision-making, at a time when therapeutic options for recurrence are expanding.
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Markar, Sheraz R
(författare)
-
Klevebro, FredrikKarolinska Institutet
(författare)
-
Johar, Asif
(författare)
-
Goense, Lucas
(författare)
-
Lagergren, PernillaKarolinska Institutet
(författare)
-
Zaninotto, Giovanni
(författare)
-
van Hillegersberg, Richard
(författare)
-
van Berge Henegouwen, Mark I
(författare)
-
Nilsson, MagnusKarolinska Institutet
(författare)
-
Hanna, George B
(författare)
-
Reynolds, John V
(författare)
-
Karolinska Institutet
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Annals of Surgery0003-49321528-1140
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Elliott, Jessie ...
-
Markar, Sheraz R
-
Klevebro, Fredri ...
-
Johar, Asif
-
Goense, Lucas
-
Lagergren, Perni ...
-
visa fler...
-
Zaninotto, Giova ...
-
van Hillegersber ...
-
van Berge Henego ...
-
Nilsson, Magnus
-
Hanna, George B
-
Reynolds, John V
-
visa färre...
- Artiklar i publikationen
-
Annals of Surger ...
- Av lärosätet
-
Uppsala universitet
-
Karolinska Institutet