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Polyphenolics from Syzygium brachythyrsum Inhibits Oxidized Low-Density Lipoprotein-Induced Macrophage-Derived Foam Cell Formation and Inflammation
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- Chen, Xue-Lian (author)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Liang, Pu-Lin (author)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Gong, Ming-Jiong (author)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Xu, Ya (author)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Zhang, Liang (author)
- Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Peoples R China.
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- Qiu, Xiao-Hui (author)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Zhang, Jing (author)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Huang, Zhi-Hai (author)
- Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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- Xu, Wen (author)
- Uppsala universitet,Institutionen för farmaceutisk biovetenskap,Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China.
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Guangzhou Univ Chinese Med, Clin Coll 2, Key Lab Qual Evaluat Chinese Med, Guangdong Prov Med Prod Adm, Guangzhou 510006, Peoples R China Anhui Agr Univ, State Key Lab Tea Plant Biol & Utilizat, Hefei 230036, Peoples R China. (creator_code:org_t)
- 2022-11-07
- 2022
- English.
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In: Foods. - : MDPI. - 2304-8158. ; 11:21
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Evidence suggests that the immunomodulatory property of polyphenols may also contribute to the reduction of cardiovascular risk. In the present study, we investigated the polyphenol extraction (PE) from Syzygium brachythyrsum, a functional food resource in south China, regarding the protective effect on inhibiting foam cell formation and the underlying molecular mechanism based on an ox-LDL-induced RAW264.7 macrophage model. The results of Oil Red O staining, Dil-ox-LDL fluorescent staining, and cholesterol efflux experiments showed that PE, and its two phenolics brachythol B (BB) and ethyl gallate (EG), significantly inhibited the foam cell formation, which may be associated with reducing the expression of SR-A1 and CD36 while increasing expression of SR-B1, ABCG1, and PPAR gamma. In addition, BB and EG also reduce the inflammatory response by down-regulating the expression of NF-kappa B and MAPK signal pathway proteins, thereby inhibiting the expression of inflammatory factors. Altogether, PE and its two components BB and EG attenuated foam cell formation and macrophage inflammation response.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- Syzygium brachythyrsum
- polyphenols
- foam cell
- ox-LDL
- cholesterol
- inflammation
Publication and Content Type
- ref (subject category)
- art (subject category)
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