Search: WFRF:(Harvey James T)
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Genetic loci and pr...
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Gorski, MathiasUniv Regensburg, Dept Genet Epidemiol, Regensburg, Germany.;Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany.,University Hospital Regensburg,University of Regensburg
(author)
Genetic loci and prioritization of genes for kidney function decline derived from a meta-analysis of 62 longitudinal genome-wide association studies
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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Elsevier,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-490015
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-490015URI
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https://doi.org/10.1016/j.kint.2022.05.021DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151151706URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-41692URI
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https://lup.lub.lu.se/record/f928a6b3-f791-4a10-acf1-27d4afcbc5cfURI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual eGFR-decline and meta-analyzed 62 longitudinal studies with eGFR assessed twice over time in all 343,339 individuals and in high-risk groups. We also explored different covariate adjustment. Twelve genomewide significant independent variants for eGFR-decline unadjusted or adjusted for eGFR- baseline (11 novel, one known for this phenotype), including nine variants robustly associated across models were identified. All loci for eGFR-decline were known for cross-sectional eGFR and thus distinguished a subgroup of eGFR loci. Seven of the nine variants showed variant- by-age interaction on eGFR cross section (further about 350,000 individuals), which linked genetic associations for eGFR-decline with agedependency of genetic cross- section associations. Clinically important were two to four-fold greater genetic effects on eGFR-decline in high-risk subgroups. Five variants associated also with chronic kidney disease progression mapped to genes with functional in- silico evidence (UMOD, SPATA7, GALNTL5, TPPP). An unfavorable versus favorable nine-variant genetic profile showed increased risk odds ratios of 1.35 for kidney failure (95% confidence intervals 1.03- 1.77) and 1.27 for acute kidney injury (95% confidence intervals 1.08-1.50) in over 2000 cases each, with matched controls). Thus, we provide a large data resource, genetic loci, and prioritized genes for kidney function decline, which help inform drug development pipelines revealing important insights into the age-dependency of kidney function genetics.
Subject headings and genre
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Rasheed, HumairaNorwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Fac Med & Hlth Sci,NTNU, Trondheim, Norway.;Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, Avon, England.
(author)
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Teumer, AlexanderUniv Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Med Univ Bialystok, Dept Populat Med & Lifestyle Dis Prevent, Bialystok, Poland.
(author)
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Thomas, Laurent F.Norwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Fac Med & Hlth Sci,NTNU, Trondheim, Norway.;Norwegian Univ Sci & Technol, NTNU, Dept Clin & Mol Med, Trondheim, Norway.;Norwegian Univ Sci & Technol, BioCore Bioinformat Core Facil, Trondheim, Norway.
(author)
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Graham, Sarah E.Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA.
(author)
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Sveinbjornsson, GardardeCODE Genet Amgen Inc, Reykjavik, Iceland.
(author)
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Winkler, Thomas W.
(author)
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Guenther, FelixUniv Regensburg, Dept Genet Epidemiol, Regensburg, Germany.;Ludwig Maximilians Univ Munchen, Dept Stat, Stat Consulting Unit StaBLab, Munich, Germany.
(author)
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Stark, Klaus J.Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany.
(author)
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Chai, Jin-FangNatl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.
(author)
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Tayo, Bamidele O.Loyola Univ Chicago, Dept Publ Hlth Sci, Maywood, IL USA.
(author)
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Wuttke, MatthiasUniv Freiburg, Inst Genet Epidemiol, Dept Biometry Epidemiol & Med Bioinformat, Fac Med, Freiburg, Germany.;Univ Freiburg, Med Ctr, Freiburg, Germany.;Univ Freiburg, Div Renal, Dept Med 4, Fac Med, Freiburg, Germany.
(author)
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Li, YongUniv Freiburg, Inst Genet Epidemiol, Dept Biometry Epidemiol & Med Bioinformat, Fac Med, Freiburg, Germany.;Univ Freiburg, Med Ctr, Freiburg, Germany.
(author)
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Tin, AdrienneUniv Mississippi, Med Ctr, Memory Impairment & Neurodegenerat Dementia MIND, Jackson, MS 39216 USA.;Univ Mississippi, Med Ctr, Dept Med, Div Nephrol, Jackson, MS 39216 USA.
(author)
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Ahluwalia, Tarunveer S.Steno Diabet Ctr Copenhagen, Gentofte, Denmark.;Univ Copenhagen, Dept Biol, Bioinformat Ctr, Copenhagen, Denmark.
(author)
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Ärnlöv, Johan,1970-Högskolan Dalarna,Karolinska Institutet,Medicinsk vetenskap,Karolinska Institutet, Stockholm(Swepub:du)jan
(author)
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Asvold, Bjorn OlavNorwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Fac Med & Hlth Sci,NTNU, Trondheim, Norway.;Trondheim Reg & Univ Hosp, St Olavs Hosp, Med Clin, Dept Endocrinol, Trondheim, Norway.
(author)
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Bakker, Stephan J. L.Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
(author)
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Banas, BernhardUniv Hosp Regensburg, Dept Nephrol, Regensburg, Germany.
(author)
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Bansal, NishaUniv Washington, Div Nephrol, Seattle, WA 98195 USA.;Univ Washington, Kidney Res Inst, Seattle, WA 98195 USA.
(author)
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Biggs, Mary L.Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA.;Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
(author)
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Biino, GinevraNatl Res Council Italy, Inst Mol Genet, Pavia, Italy.
(author)
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Bohnke, MichaelUniv Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
(author)
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Boerwinkle, EricUniv Texas Hlth Sci Ctr Houston, Ctr Human Genet, Houston, TX 77030 USA.
(author)
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Bottinger, Erwin P.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Hasso Plattner Inst, Digital Hlth Ctr, Potsdam, Germany.;Univ Potsdam, Potsdam, Germany.
(author)
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Brenner, HermannGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;Heidelberg Univ, Network Aging Res, Heidelberg, Germany.
(author)
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Brumpton, BenNorwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Fac Med & Hlth Sci,NTNU, Trondheim, Norway.;Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, Avon, England.;Trondheim Reg & Univ Hosp, St Olavs Hosp, Clin Thorac & Occupat Med, Trondheim, Norway.
(author)
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Carroll, Robert J.Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA.
(author)
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Chaker, LayalUniv Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
(author)
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Chalmers, JohnUniv New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.
(author)
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Chee, Miao-LiSingapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
(author)
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Chee, Miao-LingSingapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
(author)
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Cheng, Ching-YuNatl Univ Hlth Syst, Singapore, Singapore.;Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore.;Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore.
(author)
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Chu, Audrey Y.Merck & Co Inc, Genet, Kenilworth, NJ USA.
(author)
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Ciullo, MarinaCNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Italy.
(author)
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Cocca, MassimilianoIRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Trieste, Italy.
(author)
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Cook, James P.Univ Liverpool, Dept Hlth Data Sci, Liverpool, Merseyside, England.
(author)
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Coresh, JosefJohns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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Cusi, DanieleNatl Res Council Italy, Inst Biomed Technol, Milan, Italy.;Bio4Dreams Business Nursery Life Sci, Milan, Italy.
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de Borst, Martin H.Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
(author)
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Degenhardt, FraukeChristian Albrechts Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
(author)
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Eckardt, Kai-UweCharite Univ Med Berlin, Dept Nephrol & Med Intens Care, Berlin, Germany.;Friedrich Alexander Univ Erlangen Nurnberg FAU, Dept Nephrol & Hypertens, Erlangen, Germany.
(author)
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Endlich, KarlhansDZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Dept Anat & Cell Biol, Greifswald, Germany.
(author)
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Evans, Michele K.NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, US Natl Inst Hlth, Baltimore, MD 21224 USA.
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Feitosa, Mary F.Washington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO USA.
(author)
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Franke, AndreChristian Albrechts Univ Kiel, Inst Clin Mol Biol, Kiel, Germany.
(author)
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Freitag-Wolf, SandraUniv Kiel, Univ Hosp Schleswig Holstein, Inst Med Informat & Stat, Kiel, Germany.
(author)
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Fuchsberger, ChristianUniv Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.;Univ Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
(author)
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Gampawar, PiyushMed Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria.
(author)
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Gansevoort, Ron T.Univ Groningen, Univ Med Ctr Groningen, Dept Internal Med, Div Nephrol, Groningen, Netherlands.
(author)
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Ghanbari, MohsenUniv Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Mashhad Univ Med Sci, Sch Med, Dept Genet, Mashhad, Razavi Khorasan, Iran.
(author)
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Ghasemi, SaharUniv Med Greifswald, Inst Community Med, Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.
(author)
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Giedraitis, VilmantasUppsala universitet,Geriatrik,Molekylär geriatrik(Swepub:uu)vigie517
(author)
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Gieger, ChristianGerman Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany.;German Ctr Diabet Res DZD, Neuherberg, Germany.
(author)
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Gudbjartsson, Daniel F.deCODE Genet Amgen Inc, Reykjavik, Iceland.;Univ Iceland, Iceland Sch Engn & Nat Sci, Reykjavik, Iceland.
(author)
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Hallan, SteinNorwegian Univ Sci & Technol, NTNU, Dept Clin & Mol Med, Trondheim, Norway.;Trondheim Reg & Univ Hosp, St Olavs Hosp, Dept Nephrol, Trondheim, Norway.
(author)
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Hamet, PavelCHUM, Montreal Univ Hosp Res Ctr, Montreal, PQ, Canada.;Medpharmgene, Montreal, PQ, Canada.;CRCHUM, Montreal, PQ, Canada.
(author)
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Hishida, AsahiNagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi, Japan.
(author)
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Ho, KevinGeisinger, KHRI, Danville, PA USA.;Geisinger, Dept Nephrol, Danville, PA USA.
(author)
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Hofer, EdithMed Univ Graz, Clin Div Neurogeriatr, Dept Neurol, Graz, Austria.;Med Univ Graz, Inst Med Informat Stat & Documentat, Graz, Austria.
(author)
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Holleczek, BerndGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
(author)
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Holm, HilmadeCODE Genet Amgen Inc, Reykjavik, Iceland.
(author)
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Hoppmann, AnselmUniv Freiburg, Inst Genet Epidemiol, Dept Biometry Epidemiol & Med Bioinformat, Fac Med, Freiburg, Germany.;Univ Freiburg, Med Ctr, Freiburg, Germany.
(author)
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Horn, KatrinUniv Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.
(author)
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Hutri-Kahonen, NinaTampere Univ Hosp, Dept Pediat, Tampere, Finland.;Tampere Univ, Dept Pediat, Fac Med & Hlth Technol, Tampere, Finland.
(author)
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Hveem, KristianNorwegian Univ Sci & Technol, KG Jebsen Ctr Genet Epidemiol, Dept Publ Hlth & Nursing, Fac Med & Hlth Sci,NTNU, Trondheim, Norway.
(author)
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Hwang, Shih-JenNHLBI, Framingham Heart Study, Framingham, MA USA.;NHLBI, Populat Sci Branch, Div Intramural Res, NIH, Bldg 10, Bethesda, MD 20892 USA.
(author)
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Ikram, M. ArfanUniv Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
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Josyula, Navya ShilpaGeisinger Res, Biomed & Translat Informat Inst, Rockville, MD USA.
(author)
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Jung, BettinaUniv Hosp Regensburg, Dept Nephrol, Regensburg, Germany.;Kliniken Sudostbayern, Dept Nephrol & Rheumatol, Traunstein, Germany.;KfH Kidney Ctr Traunstein, Traunstein, Germany.
(author)
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Kahonen, MikaTampere Univ Hosp, Dept Clin Physiol, Tampere, Finland.;Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Hlth Technol, Dept Clin Physiol, Tampere, Finland.
(author)
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Karabegovic, IrmaUniv Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
(author)
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Khor, Chiea-ChuenSingapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.;Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore.
(author)
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Koenig, WolfgangTech Univ Munich, Deutsch Herzzentrum Munchen, Munich, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Univ Ulm, Inst Epidemiol & Med Biometry, Ulm, Germany.
(author)
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Kramer, HollyLoyola Univ Chicago, Dept Publ Hlth Sci, Maywood, IL USA.;Loyola Univ, Div Nephrol & Hypertens, Chicago, IL 60611 USA.
(author)
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Kramer, Bernhard K.Heidelberg Univ, Med Fac Mannheim, Dept Med Nephrol Hypertensiol Rheumatol Endocrino, Mannheim, Germany.
(author)
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Kuehnel, BrigitteGerman Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.
(author)
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Kuusisto, JohannaKuopio Univ Hosp, Dept Med, Kuopio, Finland.;Univ Eastern Finland, Ctr Med & Clin Res, Sch Med, Kuopio, Finland.
(author)
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Laakso, MarkkuKuopio Univ Hosp, Dept Med, Kuopio, Finland.;Univ Eastern Finland, Ctr Med & Clin Res, Sch Med, Kuopio, Finland.
(author)
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Lange, Leslie A.Univ Colorado Denver Anschutz Med Campus, Sch Med, Div Biomed Informat & Personalized Med, Aurora, CO USA.
(author)
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Lehtimaki, TerhoFimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Dept Clin Chem, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland.
(author)
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Li, ManUniv Utah, Dept Med, Div Nephrol & Hypertens, Salt Lake City, UT 84112 USA.
(author)
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Lieb, WolfgangUniv Kiel, Inst Epidemiol, Kiel, Germany.;Univ Kiel, Biobank Popgen, Kiel, Germany.
(author)
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Lind, LarsUppsala universitet,Klinisk epidemiologi(Swepub:uu)larslind
(author)
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Lindgren, Cecilia M.Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England.;Broad Inst MIT & Harvard, Cambridge, MA 02142 USA.;Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Nuffield Dept Womens & Reprod Hlth, Womens Ctr, John Radcliffe Hosp, Level 3, Oxford, England.;Univ Oxford, Li Ka Shing Ctr Hlth Informat & Discovery, Big Data Inst, Oxford, England.
(author)
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Loos, Ruth J. F.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA.
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Lukas, Mary AnnGlaxoSmithKline, Clin Sci, Albuquerque, NM USA.
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Lyytikainen, Leo-PekkaFimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Dept Clin Chem, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland.
(author)
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Mahajan, AnubhaUniv Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England.
(author)
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Matias-Garcia, Pamela R.German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany.;Tech Univ Munich, TUM Sch Med, Munich, Germany.
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Meisinger, ChristaGerman Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Independent Res Grp Clin Epidemiol, Neuherberg, Germany.;Univ Augsburg, Univ Hosp Augsburg, Chair Epidemiol, Augsburg, Germany.
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Meitinger, ThomasDZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.;Helmholtz Zentrum Munchen, Inst Human Genet, Neuherberg, Germany.;Tech Univ Munich, Inst Human Genet, Munich, Germany.
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Melander, O.Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Diabetes - kardiovaskulär sjukdom,Diabetes - Cardiovascular Disease(Swepub:lu)endo-mor
(author)
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Milaneschi, YuriVrije Univ, Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth, Amsterdam, Netherlands.;Vrije Univ, Amsterdam UMC, Amsterdam Neurosci, Amsterdam, Netherlands.;GGZ inGeest, Amsterdam, Netherlands.
(author)
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Mishra, Pashupati P.Fimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Dept Clin Chem, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland.
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Mononen, NinaFimlab Labs, Dept Clin Chem, Tampere, Finland.;Tampere Univ, Dept Clin Chem, Fac Med & Hlth Technol, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland.
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Morris, Andrew P.Univ Liverpool, Dept Hlth Data Sci, Liverpool, Merseyside, England.;Univ Oxford, Wellcome Ctr Human Genet, Oxford, England.;Univ Manchester, Ctr Musculoskeletal Res, Ctr Genet & Genom Versus Arthrit, Manchester, Lancs, England.
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Mychaleckyj, Josyf C.Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA.
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Nadkarni, Girish N.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Dept Med, Div Nephrol, New York, NY 10029 USA.
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Naito, MarikoNagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi, Japan.;Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Oral Epidemiol, Hiroshima, Japan.
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Nakatochi, MasahiroNagoya Univ, Grad Sch Med, Dept Integrated Hlth Sci, Publ Hlth Informat Unit, Nagoya, Aichi, Japan.
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Nalls, Mike A.NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA.;Data Tecn Int, Glen Echo, MD USA.
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Nauck, MatthiasDZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany.
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Nikus, KjellTampere Univ Hosp, Ctr Heart, Dept Cardiol, Tampere, Finland.;Tampere Univ, Finnish Cardiovasc Res Ctr Tampere, Dept Cardiol, Fac Med & Hlth Technol, Tampere, Finland.
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Ning, BotingBoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
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Nolte, Ilja M.Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
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Nutile, TeresaCNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy.
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O'Donoghue, Michelle L.Brigham & Womens Hosp, Div Cardiovasc, 75 Francis St, Boston, MA 02115 USA.;TIMI Study Grp, Boston, MA USA.
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O'Connell, JeffreyUniv Maryland, Sch Med, Baltimore, MD 21201 USA.
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Olafsson, IsleifurLandspitali Univ Hosp, Dept Clin Biochem, Reykjavik, Iceland.
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Orho-Melander, MarjuLund Univ, Diabet & Cardiovasc Dis Genet Epidemiol, Dept Clin Sci Malmö, Malmö, Sweden.
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Parsa, AfshinNIDDK, Div Kidney Urol & Hematol Dis, NIH, Bethesda, MD 20892 USA.;Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA.
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Pendergrass, Sarah A.Geisinger Res, Biomed & Translat Informat Inst, Danville, PA USA.
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Penninx, Brenda W. J. H.Vrije Univ, Amsterdam UMC, Dept Psychiat, Amsterdam Publ Hlth, Amsterdam, Netherlands.;Vrije Univ, Amsterdam UMC, Amsterdam Neurosci, Amsterdam, Netherlands.;GGZ inGeest, Amsterdam, Netherlands.
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Pirastu, MarioUOS Sassari, Natl Res Council Italy, Inst Genet & Biomed Res, Sassari, Italy.
(author)
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Preuss, Michael H.Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.
(author)
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Psaty, Bruce M.Univ Washington, Dept Hlth Serv, Dept Epidemiol, Cardiovasc Hlth Res Unit,Dept Med, Seattle, WA 98195 USA.
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Raffield, Laura M.Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA.
(author)
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Raitakari, Olli T.Univ Turku, Ctr Populat Hlth Res, Turku, Finland.;Turku Univ Hosp, Turku, Finland.;Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland.
(author)
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Rheinberger, MyriamUniv Hosp Regensburg, Dept Nephrol, Regensburg, Germany.;Kliniken Sudostbayern, Dept Nephrol & Rheumatol, Traunstein, Germany.;KfH Kidney Ctr Traunstein, Traunstein, Germany.
(author)
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Rice, Kenneth M.Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
(author)
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Rizzi, FedericaUniv Milan, Dept Hlth Sci, Milan, Italy.;ePhood SRL, ePhood Sci Unit, Milan, Italy.
(author)
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Rosenkranz, Alexander R.Med Univ Graz, Div Nephrol, Dept Internal Med, Graz, Austria.
(author)
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Rossing, PeterSteno Diabet Ctr Copenhagen, Gentofte, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.
(author)
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Rotter, Jerome I.Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90509 USA.
(author)
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Ruggiero, DanielaCNR, Inst Genet & Biophys Adriano Buzzati Traverso, Naples, Italy.;IRCCS Neuromed, Pozzilli, Italy.
(author)
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Ryan, Kathleen A.Univ Maryland, Sch Med, Div Endocrinol Diabet & Nutr, Baltimore, MD 21201 USA.
(author)
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Sabanayagam, CharumathiSingapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore.
(author)
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Salvi, ErikaUniv Milan, Dept Hlth Sci, Milan, Italy.;Fdn IRCCS Ist Neurol Carlo Besta, Neuroalgol Unit, Milan, Italy.
(author)
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Schmidt, HelenaMed Univ Graz, Ctr Mol Med, Inst Mol Biol & Biochem, Graz, Austria.
(author)
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Schmidt, ReinholdMed Univ Graz, Clin Div Neurogeriatr, Dept Neurol, Graz, Austria.
(author)
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Scholz, MarkusUniv Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany.;Univ Leipzig, LIFE Res Ctr Civilizat Dis, Leipzig, Germany.
(author)
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Schoettker, BenGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;Heidelberg Univ, Network Aging Res, Heidelberg, Germany.
(author)
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Schulz, C.-A.Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups(Swepub:lu)med-csc
(author)
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Sedaghat, SanazUniv Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA.
(author)
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Shaffer, Christian M.Vanderbilt Univ, Med Ctr, Dept Biomed Informat, Nashville, TN USA.
(author)
-
Sieber, Karsten B.GlaxoSmithKline, Human Genet, Collegeville, PA USA.
(author)
-
Sim, XuelingNatl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore.;Natl Univ Hlth Syst, Singapore, Singapore.
(author)
-
Sims, MarioUniv Mississippi, Med Ctr, Dept Med, Jackson, MS 39216 USA.
(author)
-
Snieder, HaroldUniv Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
(author)
-
Stanzick, Kira J.Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany.
(author)
-
Thorsteinsdottir, UnnurdeCODE Genet Amgen Inc, Reykjavik, Iceland.;Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland.
(author)
-
Stocker, HannahGerman Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;Heidelberg Univ, Network Aging Res, Heidelberg, Germany.
(author)
-
Strauch, KonstantinGerman Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Genet Epidemiol, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Chair Genet Epidemiol, IBE, Fac Med, Munich, Germany.;Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Med Biostat Epidemiol & Informat, Mainz, Germany.
(author)
-
Stringham, Heather M.Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA.;Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA.
(author)
-
Sulem, PatrickdeCODE Genet Amgen Inc, Reykjavik, Iceland.
(author)
-
Szymczak, SilkeUniv Kiel, Univ Hosp Schleswig Holstein, Inst Med Informat & Stat, Kiel, Germany.;Univ Lubeck, Univ Hosp Schleswig Holstein, Inst Med Biometry & Stat, Campus Lubeck, Lubeck, Germany.
(author)
-
Taylor, Kent D.Harbor UCLA Med Ctr, Inst Translat Genom & Populat Sci, Dept Pediat, Lundquist Inst Biomed Innovat, Torrance, CA 90509 USA.
(author)
-
Thio, Chris H. L.Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
(author)
-
Tremblay, JohanneCHUM, Montreal Univ Hosp Res Ctr, Montreal, PQ, Canada.;Medpharmgene, Montreal, PQ, Canada.;CRCHUM, Montreal, PQ, Canada.
(author)
-
Vaccargiu, SimonaUOS Sassari, Natl Res Council Italy, Inst Genet & Biomed Res, Sassari, Italy.
(author)
-
van der Harst, PimUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands.;Netherlands Heart Inst, Durrer Ctr Cardiovasc Res, Utrecht, Netherlands.
(author)
-
van der Most, Peter J.Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands.
(author)
-
Verweij, NiekUniv Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands.
(author)
-
Volker, UweDZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Greifswald, Germany.
(author)
-
Wakai, KenjiNagoya Univ, Grad Sch Med, Dept Prevent Med, Nagoya, Aichi, Japan.
(author)
-
Waldenberger, MelanieGerman Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, Neuherberg, Germany.;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, Neuherberg, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, Munich, Germany.
(author)
-
Wallentin, Lars,1943-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)larswall
(author)
-
Wallner, StefanUniv Hosp Regensburg, Inst Clin Chem & Lab Med, Regensburg, Germany.
(author)
-
Wang, JudyWashington Univ, Sch Med, Dept Genet, Div Stat Genom, St Louis, MO USA.
(author)
-
Waterworth, Dawn M.GlaxoSmithKline, Human Genet, Collegeville, PA USA.
(author)
-
White, Harvey D.Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand.;Univ Auckland, Auckland, New Zealand.
(author)
-
Willer, Cristen J.Univ Michigan, Dept Internal Med, Div Cardiol, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA.;Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
(author)
-
Wong, Tien-YinSingapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore.
(author)
-
Woodward, MarkUniv New South Wales, George Inst Global Hlth, Sydney, NSW, Australia.;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.;Univ Oxford, George Inst Global Hlth, Oxford, England.
(author)
-
Yang, QiongBoston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA.
(author)
-
Yerges-Armstrong, Laura M.GlaxoSmithKline, Human Genet, Collegeville, PA USA.
(author)
-
Zimmermann, MartinaUniv Regensburg, Dept Genet Epidemiol, Regensburg, Germany.
(author)
-
Zonderman, Alan B.NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, US Natl Inst Hlth, Baltimore, MD 21224 USA.
(author)
-
Bergler, TobiasUniv Hosp Regensburg, Dept Nephrol, Regensburg, Germany.
(author)
-
Stefansson, KarideCODE Genet Amgen Inc, Reykjavik, Iceland.;Univ Iceland, Sch Hlth Sci, Fac Med, Reykjavik, Iceland.
(author)
-
Boger, Carsten A.Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany.;Kliniken Sudostbayern, Dept Nephrol & Rheumatol, Traunstein, Germany.;KfH Kidney Ctr Traunstein, Traunstein, Germany.
(author)
-
Pattaro, CristianUniv Lubeck, Eurac Res, Inst Biomed, Bolzano, Italy.
(author)
-
Koettgen, AnnaUniv Freiburg, Inst Genet Epidemiol, Dept Biometry Epidemiol & Med Bioinformat, Fac Med, Freiburg, Germany.;Univ Freiburg, Med Ctr, Freiburg, Germany.;Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
(author)
-
Kronenberg, FlorianMed Univ Innsbruck, Inst Genet Epidemiol, Dept Genet & Pharmacol, Innsbruck, Austria.
(author)
-
Heid, Iris M.Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany.,University of Regensburg
(author)
-
Univ Regensburg, Dept Genet Epidemiol, Regensburg, Germany.;Univ Hosp Regensburg, Dept Nephrol, Regensburg, Germany.University Hospital Regensburg
(creator_code:org_t)
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Lifelines Cohort Study
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et al.
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