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International Valid...
International Validation of a Nomogram to Predict Recurrence after Resection of Grade 1 and 2 Nonfunctioning Pancreatic Neuroendocrine Tumors
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Heidsma, Charlotte M (författare)
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van Roessel, Stijn (författare)
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van Dieren, Susan (författare)
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visa fler...
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Engelsman, Anton F (författare)
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Strobel, Oliver (författare)
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Buechler, Markus W (författare)
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Schimmack, Simon (författare)
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Perinel, Julie (författare)
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Adham, Mustapha (författare)
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Deshpande, Vikram (författare)
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- Kjaer, Josefine (författare)
- Uppsala universitet,Endokrinkirurgi
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- Norlén, Olov (författare)
- Uppsala universitet,Endokrinkirurgi
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Gill, Anthony J (författare)
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Samra, Jaswinder S (författare)
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Mittal, Anubhav (författare)
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Hoogwater, Frederik J H (författare)
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Primavesi, Florian (författare)
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Stättner, Stefan (författare)
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Besselink, Marc G (författare)
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van Eijck, Casper H J (författare)
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Nieveen van Dijkum, E J M (författare)
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visa färre...
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(creator_code:org_t)
- 2021-07-29
- 2022
- Engelska.
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Ingår i: Neuroendocrinology. - : S. Karger. - 0028-3835 .- 1423-0194. ; 112:6, s. 571-579
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://www.karger.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Despite the low recurrence rate of resected nonfunctional pancreatic neuroendocrine tumors (NF-pNETs), nearly all patients undergo long-term surveillance. A prediction model for recurrence may help select patients for less intensive surveillance or identify patients for adjuvant therapy. The objective of this study was to assess the external validity of a recently published model predicting recurrence within 5 years after surgery for NF-pNET in an international cohort. This prediction model includes tumor grade, lymph node status and perineural invasion as predictors.METHODS: Retrospectively, data were collected from 7 international referral centers on patients who underwent resection for a grade 1-2 NF-pNET between 1992 and 2018. Model performance was evaluated by calibration statistics, Harrel's C-statistic, and area under the curve (AUC) of the receiver operating characteristic curve for 5-year recurrence-free survival (RFS). A sub-analysis was performed in pNETs >2 cm. The model was improved to stratify patients into 3 risk groups (low, medium, high) for recurrence.RESULTS: Overall, 342 patients were included in the validation cohort with a 5-year RFS of 83% (95% confidence interval [CI]: 78-88%). Fifty-eight patients (17%) developed a recurrence. Calibration showed an intercept of 0 and a slope of 0.74. The C-statistic was 0.77 (95% CI: 0.70-0.83), and the AUC for the prediction of 5-year RFS was 0.74. The prediction model had a better performance in tumors >2 cm (C-statistic 0.80).CONCLUSIONS: External validity of this prediction model for recurrence after curative surgery for grade 1-2 NF-pNET showed accurate overall performance using 3 easily accessible parameters. This model is available via www.pancreascalculator.com.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Nyckelord
- Nonfunctional pancreatic neuroendocrine tumors
- Prediction model
- Recurrence
- Risk factors
- Surgery
- Kirurgi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
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Heidsma, Charlot ...
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van Roessel, Sti ...
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van Dieren, Susa ...
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Engelsman, Anton ...
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Strobel, Oliver
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Buechler, Markus ...
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visa fler...
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Schimmack, Simon
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Perinel, Julie
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Adham, Mustapha
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Deshpande, Vikra ...
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Kjaer, Josefine
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Norlén, Olov
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Gill, Anthony J
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Samra, Jaswinder ...
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Mittal, Anubhav
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Hoogwater, Frede ...
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Primavesi, Flori ...
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Stättner, Stefan
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Besselink, Marc ...
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van Eijck, Caspe ...
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Nieveen van Dijk ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kirurgi
- Artiklar i publikationen
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Neuroendocrinolo ...
- Av lärosätet
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Uppsala universitet