Prenatal exposure to fluoxetine modulates emotionality and aversive memory in male and female rat offspring

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Linhares, Sarah Sophia G.Univ Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, Natal, RN, Brazil. (författare)

During pregnancy, women are prone to depression, for which selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine. are usually the first-line treatment. However, fluoxetine can cross the placental barrier and affect fetuses, causing changes in serotonin levels early in life. Long-term effects in the brain circuits that control cognitive and emotional behavior are related to early fluoxetine exposure during development. In this study, we aimed to investigate whether fluoxetine exposure (10 mg/kg/day) from the 13th gestational day (GD13) to GD21 may lead to behavioral emotional-cognitive changes in male and female rat offspring approximately 90 days postnatally (similar to PN90). We have analyzed the performance of individuals in the open field and in the plus-maze discriminative avoidance task, which assesses anxiety and learning/memory processing behaviors. We have found that prenatal (GD13-GD21) exposure to fluoxetine strengthened aversive memory and induced higher anxiety levels in males, and quick extinction of aversive memory in females. Taken together, these results suggest that early exposure to fluoxetine impairs the basal state of anxiety and the cognitive functions of rats during adulthood, which may be in a sex-specific manner because males appear more susceptible than females.

Meurer, Ywlliane da Silva R.Univ Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, Natal, RN, Brazil. (författare)
de Aquino, Antonio Carlos QueirozUniv Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, Natal, RN, Brazil. (författare)
Camara, Diego de AquinoUniv Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, Natal, RN, Brazil. (författare)
Brandao, Luiz Eduardo M.Uppsala universitet,Transplantation och regenerativ medicin(Swepub:uu)luima191 (författare)
Fiuza, Felipe PortoEdmond & Lily Safra Int Inst Neurosci, St Dumont Inst, Grad Program Neuroengn, Macaiba, Brazil. (författare)
Lima, Ramon HypolitoEdmond & Lily Safra Int Inst Neurosci, St Dumont Inst, Grad Program Neuroengn, Macaiba, Brazil. (författare)
Engelberth, Rovena Clara J. G.Univ Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, Natal, RN, Brazil. (författare)
Cavalcante, Jeferson SouzaUniv Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, Natal, RN, Brazil.;Univ Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, BR-59072970 Brazi, RN, Brazil. (författare)
Univ Fed Rio Grande do Norte, Biosci Ctr, Dept Physiol, Lab Neurochem Studies, Natal, RN, Brazil.Transplantation och regenerativ medicin (creator_code:org_t)

Ingår i:Behavioural Pharmacology: Lippincott Williams & Wilkins33:8, s. 575-5880955-88101473-5849

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