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COVID‐19 outcomes i...
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Lim, Yeong JerHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
(författare)
COVID‐19 outcomes in haematopoietic cell transplant recipients : A systematic review and meta‐analysis
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
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2022-06-14
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USA :John Wiley & Sons,2022
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-490689
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-490689URI
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https://doi.org/10.1002/jha2.465DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Up-to-date information on coronavirus disease 2019 (COVID-19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID-19 mitigation strategies. We performed a meta-analysis to address this knowledge gap. All studies with at least five patients who reported COVID-19-related deaths in HCT recipients were included. The primary outcome was COVID-19-related death. Secondary outcomes were COVID-19-related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID-19-related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%–24%), while MV and ITU admission rates were 14% (95% CI 11%–17%) and 18% (95% CI 14%–22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID-19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09–3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38–3.20) or in the context of active graft-versus-host disease (RR 2.38, 95% CI 1.10–5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID-19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID-19 outcomes.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Khan, UmairHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
(författare)
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Karpha, IndraniHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
(författare)
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Ross, AndrewHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK
(författare)
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Saif, MuhammadHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK
(författare)
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Remberger, Mats,Professor,1955-Uppsala universitet,Institutionen för medicinska vetenskaper,KFUE, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)matre804
(författare)
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Kalakonda, NageshHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
(författare)
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Pettitt, Andrew R.Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
(författare)
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Floisand, YngvarHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine University of Oslo Oslo Norway
(författare)
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Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UKHaemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK
(creator_code:org_t)
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Ingår i:eJHaemUSA : John Wiley & Sons3:3, s. 862-8722688-6146
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Lim, Yeong Jer
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Khan, Umair
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Karpha, Indrani
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Ross, Andrew
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Saif, Muhammad
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Remberger, Mats, ...
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visa fler...
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Kalakonda, Nages ...
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Pettitt, Andrew ...
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Floisand, Yngvar
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eJHaem
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Uppsala universitet