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COVID‐19 outcomes i...
COVID‐19 outcomes in haematopoietic cell transplant recipients : A systematic review and meta‐analysis
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- Lim, Yeong Jer (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
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- Khan, Umair (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
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- Karpha, Indrani (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
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- Ross, Andrew (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK
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- Saif, Muhammad (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK
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- Remberger, Mats, Professor, 1955- (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,KFUE, Uppsala University Hospital, Uppsala, Sweden
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- Kalakonda, Nagesh (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
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- Pettitt, Andrew R. (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Institute of Systems, Molecular and Integrative Biology University of Liverpool Liverpool UK
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- Floisand, Yngvar (author)
- Haemato‐oncology Department Clatterbridge Cancer Centre NHS Foundation Trust Liverpool UK;Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine University of Oslo Oslo Norway
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(creator_code:org_t)
- 2022-06-14
- 2022
- English.
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In: eJHaem. - USA : John Wiley & Sons. - 2688-6146. ; 3:3, s. 862-872
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Abstract
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- Up-to-date information on coronavirus disease 2019 (COVID-19) outcomes and risk factors in haematopoietic cell transplantation (HCT) recipients is required to inform on decisions about cancer treatment and COVID-19 mitigation strategies. We performed a meta-analysis to address this knowledge gap. All studies with at least five patients who reported COVID-19-related deaths in HCT recipients were included. The primary outcome was COVID-19-related death. Secondary outcomes were COVID-19-related mechanical ventilation (MV) and intensive care unit (ITU) admission. The cumulative COVID-19-related death rate among HCT recipients was 21% (95% confidence interval [CI] 18%–24%), while MV and ITU admission rates were 14% (95% CI 11%–17%) and 18% (95% CI 14%–22%), respectively. Subgroup analysis showed higher death rates in patients who developed COVID-19 within 12 months of HCT (risk ratio [RR] 1.82, 95% CI 1.09–3.03), within 6 months of receiving immunosuppressant drugs (RR 2.11, 95% CI 1.38–3.20) or in the context of active graft-versus-host disease (RR 2.38, 95% CI 1.10–5.16). Our findings support the idea that HCT should remain an integral part of cancer treatment during the COVID-19 pandemic but also highlight the need to prioritise preventative measures in those patients who are at increased risk of adverse COVID-19 outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
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eJHaem
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Lim, Yeong Jer
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Khan, Umair
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Karpha, Indrani
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Ross, Andrew
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Saif, Muhammad
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Remberger, Mats, ...
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Kalakonda, Nages ...
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Pettitt, Andrew ...
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Floisand, Yngvar
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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eJHaem
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Uppsala University