Atrial Functional Mitral Regurgitation: A JACC: Cardiovascular Imaging Expert Panel Viewpoint

Atrial Functional Mitral Regurgitation : A JACC: Cardiovascular Imaging Expert Panel Viewpoint

Functional or secondary mitral regurgitation (MR) is associated with increased cardiovascular morbidity and mortality. Mechanistically, secondary MR is attributable to an imbalance between mitral leaflet tethering and closure forces, leading to poor coaptation. The pathophysiology of functional MR is most often the result of abnormalities in left ventricular function and remodeling, seen in ischemic or nonischemic conditions. Less commonly and more recently recognized is the scenario in which left ventricular geometry and function are preserved, the culprit being mitral annular enlargement associated with left atrial dilatation, termed atrial functional mitral regurgitation (AFMR). This most commonly occurs in the setting of chronic atrial fibrillation or heart failure with preserved ejection fraction. There is variability in the published reports and in current investigations as to the definition of AFMR. This paper reviews the pathophysiology of AFMR and focus on the need for a collective definition of AFMR to facilitate consistency in reported data and enhance much-needed research into outcomes and treatment strategies in AFMR.

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kardiologi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Cardiac and Cardiovascular Systems hsv//eng
atrial fibrillation
atrial functional mitral regurgitation
functional mitral regurgitation
heart failure with preserved ejection fraction
ventricular functional mitral regurgitation

Levine, Robert A (author)
Flachskampf, Frank,1957-Uppsala universitet,Klinisk fysiologi(Swepub:uu)frafl698 (author)
Grayburn, Paul (author)
Gillam, Linda (author)
Leipsic, Jonathon (author)
Thomas, James D (author)
Kwong, Raymond Y (author)
Vandervoort, Pieter (author)
Chandrashekhar, Y (author)
Uppsala universitetKlinisk fysiologi (creator_code:org_t)

By the author/editor: Zoghbi, William ...; Levine, Robert A; Flachskampf, Fra ...; Grayburn, Paul; Gillam, Linda; Leipsic, Jonatho ...; show more...; Thomas, James D; Kwong, Raymond Y; Vandervoort, Pie ...; Chandrashekhar, ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

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