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- Dauter, Ulrike MariaKarolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden. (författare)
Cancer-related changes and low-to-moderate exposure to welding fumes : A longitudinal study
- Artikel/kapitelEngelska2022
Förlag, utgivningsår, omfång ...
- 2021-09-27
- Scandinavian Journal of Work, Environment and Health,2022
- electronicrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:uu-492114
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-492114URI
- https://doi.org/10.5271/sjweh.3988DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:151376067URI
- https://lup.lub.lu.se/record/747f5911-c15c-4a74-af29-b7b98540a338URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
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- SwePubSwePub
Klassifikation
Anmärkningar
- Objective This study tested for an association between early cancer-related biomarkers and low-to-moderate exposure to fumes from welding mild steel.Methods Male, non-smoking participants from southern Sweden were recruited and examined (N=338, 171 welders and 167 controls); of these, 78 welders and 96 controls were examined on two occasions six years apart. Exposure to welding fumes was evaluated by measuring respirable dust, welding years, and cumulative exposure. DNA methylation of CpG sites within the cancer-related genes AHRR, F2RL3, and B3GNTL1 was measured by pyrosequencing and relative mitochondrial DNA copy number and telomere length were measured by qPCR in whole-blood samples. Multivariate models were used for longitudinal analysis.Results Median exposure to respirable dust was 0.7 mg/m3 at both timepoints, adjusted for use of personal protective equipment. Compared with controls, welders showed a significant decrease over time in DNA methylation of B3GNTL1 CpG1 and CpG4 [adjusted for age, body mass index, and smoking: β=-0.66, standard error (SE)=0.28; β=-0.48, SE=0.24, respectively]. In addition, exposure to respirable dust and cumulative exposure was associated with a decrease in methylation of F2RL3 CpG2 among all welders (adjusted β=-0.67, SE=0.23 and β=-0.03, SE=0.02, respectively). No significant associations were found for AHRR, mitochondrial DNA copy number, or telomere length.Conclusion Low-to-moderate exposure to welding fumes was associated with a small effect on selected early epigenetic biomarkers of cancer. The direction of the methylation pattern (lower methylation of specific CpG sites) indicates early lung cancer-related changes associated with mild steel welding.
Ämnesord och genrebeteckningar
- MEDICIN OCH HÄLSOVETENSKAP Hälsovetenskap Arbetsmedicin och miljömedicin hsv//swe
- MEDICAL AND HEALTH SCIENCES Health Sciences Occupational Health and Environmental Health hsv//eng
- AHRR
- B3GNTL1
- DNA Methylation
- F2RL3
- lung cancer
- mitochondrial DNA
- occupational exposure
- respirable dust
- telomere length
- B3GNTL1
- DNA Methylation
- F2RL3
- Key terms AHRR
- lung cancer
- mitochondrial DNA
- occupational exposure
- respirable dust
- telomere length
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Alhamdow, AymanKarolinska Institute,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.(Swepub:lu)med-aa10 (författare)
- Cediel-Ulloa, AndreaUppsala University,Karolinska Institute,Uppsala universitet,Fysiologi och miljötoxikologi,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden(Swepub:uu)andce270 (författare)
- Gliga, Anda RoxanaKarolinska Institute(Swepub:lu)an3300gl (författare)
- Albin, MariaKarolinska Institute,Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Miljöepidemiologi,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Environmental Epidemiology,Lund University Research Groups(Swepub:lu)ymed-mal (författare)
- Broberg, KarinKarolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Karolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden.;Lund Univ, Div Occupat & Environm Med, Dept Lab Med, Lund, Sweden.,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Genetisk arbets- och miljömedicin,Forskargrupper vid Lunds universitet,LTH profilområde: Aerosoler,LTH profilområden,Lunds Tekniska Högskola,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Genetic Occupational and Environmental Medicine,Lund University Research Groups,LTH Profile Area: Aerosols,LTH Profile areas,Faculty of Engineering, LTH(Swepub:lu)kgen-kbr (författare)
- Karolinska InstitutetKarolinska Inst, Inst Environm Med, Nobels Vag 13, S-17177 Stockholm, Sweden. (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Scandinavian Journal of Work, Environment and Health: Scandinavian Journal of Work, Environment and Health48:1, s. 21-300355-31401795-990X
Internetlänk
- https://doi.org/10.5271/sjweh.3988Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1732575/FULLTEXT01.pdffulltext:print
- https://www.sjweh.fi/download.php?abstract_id=3988&file_nro=1
- http://dx.doi.org/10.5271/sjweh.3988FULLTEXT
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-492114
- https://doi.org/10.5271/sjweh.3988
- http://kipublications.ki.se/Default.aspx?queryparsed=id:151376067
- https://lup.lub.lu.se/record/747f5911-c15c-4a74-af29-b7b98540a338
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- Scandinavian Journal of Work, Environment and Health (Sök värdpublikationen i LIBRIS)
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