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Early Mid-pregnancy...
Early Mid-pregnancy Blood-Based Proteins as Possible Biomarkers of Increased Infant Birth Size in Sex-Stratified Analyses
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- Lindberger, Emelie (author)
- Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning
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- Ahlsson, Fredrik, 1967- (author)
- Uppsala universitet,Perinatal, neonatal och barnkardiologisk forskning
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- Junus, Katja, 1982- (author)
- Uppsala universitet,Klinisk obstetrik
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- Kunovac Kallak, Theodora, 1985- (author)
- Uppsala universitet,Reproduktiv hälsa
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- Lager, Susanne (author)
- Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning
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- Nordlöf-Callbo, Paliz (author)
- Uppsala universitet,Klinisk obstetrik
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- Wikström, Anna-Karin, 1965- (author)
- Uppsala universitet,Klinisk obstetrik
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- Sundström Poromaa, Inger, 1964- (author)
- Uppsala universitet,Reproduktiv hälsa
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(creator_code:org_t)
- 2022-09-30
- 2023
- English.
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In: Reproductive Sciences. - : Springer. - 1933-7191 .- 1933-7205. ; 30, s. 1165-1175
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- The objective of this study was to evaluate the associations of 92 maternal blood-based proteins with increased infant birth size. The study was performed at the Uppsala University Hospital, Sweden, and included 857 mother and child dyads. The mean age of the women was 30.3 years, and 53.2% were nulliparous. Blood samples were collected at mean 18 + 2 weeks' gestation, and the Olink cardiovascular II panel was used to measure 92 proteins, either known to be or suspected to be markers of cardiovascular and inflammatory disease in humans. Multiple linear regression models adjusted for maternal age, parity, pre-conception BMI, height, and smoking were performed to evaluate the association of each individual protein with infant birth size. We also performed sex-stratified analyses. Eight proteins (Matrix metalloproteinase-12 (MMP-12), Prostasin (PRSS8), Adrenomedullin (ADM), Pappalysin-1 (PAPP-A), Angiotensin-converting enzyme 2 (ACE2), Sortilin (SORT1), Lectin-like oxidized LDL receptor 1 (LOX-1), and Thrombomodulin (TM)) were associated with infant birth size after false discovery rate adjustment. In the analyses including only female infants, ten proteins (MMP-12, Growth/differentiation factor 2 (GDF-2), PRSS8, SORT1, ADM, Interleukin-1 receptor antagonist protein (IL-1ra), Leptin (LEP), ACE2, TM, and Tumor necrosis factor receptor superfamily member 11A (TNFRSF11A)) were associated with infant birth size. Two proteins (PAPP-A and PRSS8) were associated with infant birth size among male infants. Our study suggests several proteins as potential biomarkers for increased birth weight, and our findings could act as a base for future research to identify new potential markers that could be added to improve screening for large infants.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- Biomarkers
- Birth weight
- Pregnancy
- Proteins
Publication and Content Type
- ref (subject category)
- art (subject category)
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