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The Dynamics of Ada...
The Dynamics of Adaptation to Stress from Standing Genetic Variation and de novo Mutations
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- Ament-Velásquez, Sandra Lorena, Ph.D. 1988- (author)
- Stockholms universitet,Avdelningen för populationsgenetik,Stockholm Univ, Dept Zool, Div Populat Genet, Svante Arrheniusvag 18 B, S-10691 Stockholm, Sweden.
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- Gilchrist, Ciaran (author)
- Stockholms universitet,Avdelningen för populationsgenetik,Stockholm Univ, Dept Zool, Div Populat Genet, Svante Arrheniusvag 18 B, S-10691 Stockholm, Sweden.
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- Rêgo, Alexandre (author)
- Stockholms universitet,Avdelningen för populationsgenetik,Stockholm Univ, Dept Zool, Div Populat Genet, Svante Arrheniusvag 18 B, S-10691 Stockholm, Sweden.
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- Bendixsen, Devin P. (author)
- Stockholms universitet,Avdelningen för populationsgenetik,Stockholm Univ, Dept Zool, Div Populat Genet, Svante Arrheniusvag 18 B, S-10691 Stockholm, Sweden.
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- Brice, Claire (author)
- Stockholms universitet,Avdelningen för populationsgenetik,Stockholm Univ, Dept Zool, Div Populat Genet, Svante Arrheniusvag 18 B, S-10691 Stockholm, Sweden.
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- Grosse-Sommer, Julie Michelle (author)
- Stockholms universitet,Avdelningen för populationsgenetik,Maastricht University, The Netherlands,Maastricht Univ, Fac Sci & Engn, Paul Henri Spaaklaan 1, NL-6229 EN Maastricht, Netherlands.
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- Rafati, Nima (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Stelkens, Rike, 1978- (author)
- Stockholms universitet,Avdelningen för populationsgenetik,Stockholm Univ, Dept Zool, Div Populat Genet, Svante Arrheniusvag 18 B, S-10691 Stockholm, Sweden.
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(creator_code:org_t)
- 2022-11-05
- 2022
- English.
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In: Molecular biology and evolution. - : Oxford University Press. - 0737-4038 .- 1537-1719. ; 39:11
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Abstract
Subject headings
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- Adaptation from standing genetic variation is an important process underlying evolution in natural populations, but we rarely get the opportunity to observe the dynamics of fitness and genomic changes in real time. Here, we used experimental evolution and Pool-Seq to track the phenotypic and genomic changes of genetically diverse asexual populations of the yeast Saccharomyces cerevisiae in four environments with different fitness costs. We found that populations rapidly and in parallel increased in fitness in stressful environments. In contrast, allele frequencies showed a range of trajectories, with some populations fixing all their ancestral variation in <30 generations and others maintaining diversity across hundreds of generations. We detected parallelism at the genomic level (involving genes, pathways, and aneuploidies) within and between environments, with idiosyncratic changes recurring in the environments with higher stress. In particular, we observed a tendency of becoming haploid-like in one environment, whereas the populations of another environment showed low overall parallelism driven by standing genetic variation despite high selective pressure. This work highlights the interplay between standing genetic variation and the influx of de novo mutations in populations adapting to a range of selective pressures with different underlying trait architectures, advancing our understanding of the constraints and drivers of adaptation.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
Keyword
- microbial experimental evolution
- yeast
- adaptation dynamics
- environmental stress
- parallelism
- time series
- Pool-Seq
- Ecology and Evolution
Publication and Content Type
- ref (subject category)
- art (subject category)
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