SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Zou Runyu)
 

Sökning: WFRF:(Zou Runyu) > (2023) > Association between...

  • Bellavia, AndreaUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA. (författare)

Association between chemical mixtures and female fertility in women undergoing assisted reproduction in Sweden and Estonia

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier,2023
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-495408
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495408URI
  • https://doi.org/10.1016/j.envres.2022.114447DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:151531011URI
  • https://res.slu.se/id/publ/119215URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Objective: Women of reproductive age are exposed to ubiquitous chemicals such as phthalates, parabens, and per -and polyfluoroalkyl substances (PFAS), which have potential endocrine disrupting properties and might affect fertility. Our objective was to investigate associations between potential endocrine-disrupting chemicals (EDCs) and female fertility in two cohorts of women attending fertility clinics.Methods: In a total population of 333 women in Sweden and Estonia, we studied the associations between chemicals and female fertility, evaluating ovarian sensitivity index (OSI) as an indicator of ovarian response, as well as clinical pregnancy and live birth from fresh and frozen embryo transfers. We measured 59 chemicals in follicular fluid samples and detected 3 phthalate metabolites, di-2-ethylhexyl phthalate (DEHP) metabolites, 1 paraben, and 6 PFAS in > 90% of the women. Associations were evaluated using multivariable-adjusted linear or logistic regression, categorizing EDCs into quartiles of their distributions, as well as with Bayesian Kernel Ma-chine Regression.Results: We observed statistically significant lower OSI at higher concentrations of the sum of DEHP metabolites in the Swedish cohort (Q4 vs Q1, beta =-0.21, 95% CI:-0.38,-0.05) and methylparaben in the Estonian cohort (Q3 vs Q1, beta =-0.22, 95% CI:-0.44,-0.01). Signals of potential associations were also observed at higher concentrations of PFUnDA in both the combined population (Q2 vs. Q1,beta =-0.16, 95% CI-0.31,-0.02) and the Estonian population (Q2 vs. Q1,beta =-0.27, 95% CI-0.45,-0.08), and for PFOA in the Estonian population (Q4 vs. Q1, beta =-0.31, 95% CI-0.61,-0.01). Associations of chemicals with clinical pregnancy and live birth presented wide confidence intervals.Conclusions: Within a large chemical mixture, we observed significant inverse associations levels of DEHP me-tabolites and methylparaben, and possibly PFUnDA and PFOA, with OSI, suggesting that these chemicals may contribute to altered ovarian function and infertility in women.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Zou, RunyuUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (författare)
  • Björvang, Richelle D.Karolinska Institutet (författare)
  • Roos, KristineTallinn Univ Technol, Dept Chem & Biotechnol, Akad Tee 15, EE-12618 Tallinn, Estonia.;Nova Vita Clin AS, Tallinn, Estonia. (författare)
  • Sjunnesson, YlvaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)47737 (författare)
  • Hallberg, IdaSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för kliniska vetenskaper (KV),Department of Clinical Sciences(Swepub:slu)48827 (författare)
  • Holte, JanUppsala universitet,Reproduktionsbiologi,Carl von Linnekliniken, Uppsala, Sweden.(Swepub:uu)janho845 (författare)
  • Pikki, AnneCarl von Linnekliniken, Uppsala, Sweden.;Uppsala Univ, Dept Womens & Childrens Hlth, Uppsala, Sweden. (författare)
  • Lenters, VirissaUniv Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (författare)
  • Portengen, LützenUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands. (författare)
  • Koekkoek, JaccoVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Sect Environm & Hlth, Amsterdam, Netherlands. (författare)
  • Lamoree, MarjaVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Sect Environm & Hlth, Amsterdam, Netherlands. (författare)
  • Van Duursen, MajorieVrije Univ Amsterdam, Amsterdam Inst Life & Environm, Sect Environm & Hlth, Amsterdam, Netherlands. (författare)
  • Vermeulen, RoelUniv Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (författare)
  • Salumets, AndresKarolinska Institutet (författare)
  • Velthut-Meikas, AgneTallinn Univ Technol, Dept Chem & Biotechnol, Akad Tee 15, EE-12618 Tallinn, Estonia. (författare)
  • Damdimopoulou, PauliinaKarolinska Institutet (författare)
  • Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA USA.Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands.;Univ Utrecht, Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands. (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Sammanhörande titlar

  • Ingår i:Environmental Research: Elsevier216:Part 10013-93511096-0953

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy