Allosteric Modulators of Dopamine D-2 Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis

Kaczor, Agnieszka A.Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland.;Univ Eastern Finland, Sch Pharm, Yliopistonranta 1,POB 1627, FI-70211 Kuopio, Finland. (författare)

Allosteric Modulators of Dopamine D-2 Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases : Overview, Pharmacology, Structural Aspects and Synthesis

Allosteric modulation of G protein-coupled receptors (GPCRs) is nowadays a hot topic in medicinal chemistry. Allosteric modulators, i.e., compounds which bind in a receptor site topologically distinct from orthosteric sites, exhibit a number of advantages. They are more selective, safer and display a ceiling effect which prevents overdosing. Allosteric modulators of dopamine D-2 receptor are potential drugs against a number of psychiatric and neurological diseases, such as schizophrenia and Parkinson's disease. In this review, an insightful summary of current research on D-2 receptor modulators is presented, ranging from their pharmacology and structural aspects of ligand-receptor interactions to their synthesis.

Wrobel, Tomasz M.Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland. (författare)
Bartuzi, DamianUppsala universitet,Beräkningsbiologi och bioinformatik,Science for Life Laboratory, SciLifeLab,Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland.(Swepub:uu)damba256 (författare)
Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland.;Univ Eastern Finland, Sch Pharm, Yliopistonranta 1,POB 1627, FI-70211 Kuopio, Finland.Med Univ Lublin, Fac Pharm, Dept Synth & Chem Technol Pharmaceut Subst Comp M, 4A Chodzki St, PL-20093 Lublin, Poland. (creator_code:org_t)

Av författaren/redakt...: Kaczor, Agnieszk ...; Wrobel, Tomasz M ...; Bartuzi, Damian

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