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  • Tislevoll, Benedicte SjoUniv Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway. (author)

Early response evaluation by single cell signaling profiling in acute myeloid leukemia

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2023-01-07
  • Springer Nature,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-495907
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-495907URI
  • https://doi.org/10.1038/s41467-022-35624-4DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of extracellular-signal-regulated kinase (ERK) 1/2 and p38 mitogen-activated protein kinase (MAPK) phosphorylation in the myeloid cell compartment 24 h post-chemotherapy is a significant predictor of patient 5-year overall survival in this cohort. Validation by RNA sequencing shows induction of MAPK target gene expression in patients with high phosphoERK1/2 24 h post-chemotherapy, while proteomics confirm an increase of the p38 prime target MAPK activated protein kinase 2 (MAPKAPK2). In this study, we demonstrate that mass cytometry can be a valuable tool for early response evaluation in AML and elucidate the potential of functional signaling analyses in precision oncology diagnostics.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Hellesoy, MonicaHaukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway. (author)
  • Fagerholt, Oda Helen EckUniv Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway. (author)
  • Gullaksen, Stein-ErikHaukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway. (author)
  • Srivastava, AashishK2 Haukeland Univ Hosp, Clin Lab, Genome Core Facil, Bergen, Norway. (author)
  • Birkeland, EvenUniv Bergen, Prote Facil Univ Bergen Probe, Bergen, Norway. (author)
  • Kleftogiannis, DimitriosUniv Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.;Univ Bergen, Ctr Canc, Dept Informat, Biomarkers & Computat Biol Unit, Bergen, Norway. (author)
  • Ayuda-Duran, PilarNorwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, Montebello, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway. (author)
  • Piechaczyk, LaureNorwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, Montebello, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Univ Oslo, Facu Med, Oslo, Norway. (author)
  • Tadele, Dagim ShiferawOslo Univ Hosp, Dept Mol Genet, Div Lab Med, Oslo, Norway.;Cleveland Clin, Dept Translat Hematol & Oncol Res, Cleveland, OH 44106 USA. (author)
  • Skavland, JornUniv Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway. (author)
  • Baliakas, Panagiotis,1977-Uppsala universitet,Science for Life Laboratory, SciLifeLab,Cancerprecisionsmedicin(Swepub:uu)panba345 (author)
  • Hovland, RandiHaukeland Hosp, Ctr Med Genet & Mol Med, Bergen, Norway. (author)
  • Andresen, VibekeUniv Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway. (author)
  • Seternes, Ole MortenUiT Arctic Univ Norway, Dept Pharm, N-9037 Tromso, Norway. (author)
  • Tvedt, Tor Henrik AndersonOslo Univ Hosp, Dept Hematol, Oslo, Norway. (author)
  • Aghaeepour, NimaStanford Univ, Dept Anesthesiol Perioperat & Pain Med, Sch Med, Stanford, CA 94121 USA.;Stanford Univ, Dept Pediat, Sch Med, Stanford, CA 94121 USA.;Stanford Univ, Dept Biomed Informat, Sch Med, Stanford, CA 94121 USA. (author)
  • Gavasso, SoniaUniv Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.;Univ Bergen, Ctr Clin Treatment Res NeuroSysMed, Dept Clin Sci, Bergen, Norway. (author)
  • Porkka, KimmoHelsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Helsinki, Finland. (author)
  • Jonassen, IngeUniv Bergen, Ctr Canc, Dept Informat, Biomarkers & Computat Biol Unit, Bergen, Norway. (author)
  • Floisand, YngvarUniv Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Oslo Univ Hosp, Dept Hematol, Oslo, Norway. (author)
  • Enserink, JorritNorwegian Radium Hosp, Inst Canc Res, Dept Mol Cell Biol, Montebello, N-0379 Oslo, Norway.;Univ Oslo, Fac Med, Ctr Canc Cell Reprogramming, Inst Clin Med, N-0318 Oslo, Norway.;Univ Oslo, Fac Math & Nat Sci, Sect Biochem & Mol Biol, N-0037 Oslo, Norway. (author)
  • Blaser, NelloUniv Bergen, Dept Informat, Bergen, Norway. (author)
  • Gjertsen, Bjorn ToreUniv Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.;Haukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway. (author)
  • Univ Bergen, Ctr Canc Biomarkers CCBIO, Dept Clin Sci, Bergen, Norway.Haukeland Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway. (creator_code:org_t)

Related titles

  • In:Nature Communications: Springer Nature14:12041-1723

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