SwePub
Sök i LIBRIS databas

  Extended search

WFRF:(Lazarevic S.)
 

Search: WFRF:(Lazarevic S.) > (2020-2023) > Differences Sustain...

  • Foeldvari, IvanSchon Klin Hamburg Eilbek, Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany. (author)

Differences Sustained Between Diffuse and Limited Forms of Juvenile Systemic Sclerosis in an Expanded International Cohort

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • 2022-06-08
  • John Wiley & Sons,2022
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-496022
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-496022URI
  • https://doi.org/10.1002/acr.24609DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Objective To evaluate the baseline clinical characteristics of juvenile systemic sclerosis (SSc) patients in the international juvenile SSc inception cohort, and to compare these characteristics between the classically defined juvenile diffuse cutaneous SSc (dcSSc) and limited cutaneous SSc (lcSSc) subtypes and among those with overlap features. Methods A cross-sectional study was performed using baseline visit data. Information on demographic characteristics, organ system evaluation, treatment, and patient- and physician-reported outcomes was extracted and summary statistics applied. Comparisons between juvenile dcSSc and lcSSc subtypes and patients with and without overlap features were performed using chi-square and Mann-Whitney U tests. Results At data extraction, 150 juvenile SSc patients were enrolled across 42 centers; 83% were White, 80% were female, juvenile dcSSc predominated (72%), and 17% of the cohort had overlap features. Significant differences were found between juvenile dcSSc and juvenile lcSSc regarding modified Rodnan skin thickness score, the presence of Gottron's papules, digital tip ulceration, results of the 6-minute walk test, and composite pulmonary and cardiac involvement. All of these were more frequent in dcSSc except for cardiac involvement. Juvenile dcSSc patients had significantly worse scores for physician-rated disease activity and damage. A significantly higher occurrence of Gottron's papules and musculoskeletal and composite pulmonary involvement, and a significantly lower frequency of Raynaud's phenomenon, were seen in those with overlap features. Conclusion Results from a large international juvenile SSc cohort demonstrate significant differences between juvenile dcSSc and juvenile lcSSc patients, including more globally severe disease and increased frequency of interstitial lung disease in juvenile dcSSc patients, while those with lcSSc have more frequent cardiac involvement. Those with overlap features had an unexpected higher frequency of interstitial lung disease.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Klotsche, JensGerman Rheumatism Res Ctr, Berlin, Germany. (author)
  • Kasapcopur, OzgurIstanbul Univ Cerrahpasa, Cerrahpasa Med Sch, Istanbul, Turkey. (author)
  • Adrovic, AmraIstanbul Univ Cerrahpasa, Cerrahpasa Med Sch, Istanbul, Turkey. (author)
  • Terreri, Maria TeresaUniv Fed Sao Paulo, Sao Paulo, Brazil. (author)
  • Sakamoto, Ana PaulaUniv Fed Sao Paulo, Sao Paulo, Brazil. (author)
  • Stanevicha, ValdaRiga Stradins Univ, Univ Children Hosp, Riga, Latvia. (author)
  • Sztajnbok, FlavioUniv Estado, Rio De Janeiro, Brazil. (author)
  • Anton, JordiUniv Barcelona, Esplugues, Hosp St Joan de Deu, Barcelona, Spain. (author)
  • Feldman, BrianHosp Sick Children, SickKids, Toronto, ON, Canada. (author)
  • Alexeeva, EkaterinaSechenov First Moscow State Med Univ, Minist Hlth Russian Federat, Natl Med Res Ctr Childrens Hlth, Moscow, Russia. (author)
  • Katsicas, MariaHosp Pediat JP Garrahan, Buenos Aires, DF, Argentina. (author)
  • Smith, VanessaUniv Ghent, Ghent, Belgium.;Ghent Univ Hosp, Ghent, Belgium. (author)
  • Avcin, TadejUniv Med Ctr Ljubljana, Univ Childrens Hosp, Ljubljana, Slovenia. (author)
  • Marrani, EdoardoMeyer Childrens Hosp, Florence, Italy. (author)
  • Kostik, MikhailSt Petersburg State Pediat Med Univ, St Petersburg, Russia. (author)
  • Lehman, ThomasHosp Special Surg, 535 E 70th St, New York, NY 10021 USA. (author)
  • Sifuentes-Giraldo, Walter-AlbertoUniv Hosp Ramon y Cajal, Madrid, Spain. (author)
  • Vasquez-Canizares, NataliaChildrens Hosp Montefiore, Bronx, NY USA. (author)
  • Appenzeller, SimoneUniv Estadual Campinas, Sch Med Sci, Sao Paulo, Brazil. (author)
  • Janarthanan, MaheshSri Ramachandra Univ, Chennai, Tamil Nadu, India. (author)
  • Moll, MonikaUniv Tubingen, Tubingen, Germany. (author)
  • Nemcova, DanaCharles Univ Prague, Prague, Czech Republic. (author)
  • Patwardhan, AnjaliUniv Missouri, Columbia, MO 65211 USA. (author)
  • Santos, Maria JoseHosp Garcia de Orta, Almada, Portugal. (author)
  • Sawhney, SujataSir Ganga Ram Hosp, Delhi, India. (author)
  • Schonenberg-Meinema, DienekeUniv Amsterdam, Amsterdam Univ Med Ctr, Emma Childrens Hosp, Amsterdam, Netherlands. (author)
  • Battagliotti, CristinaHosp Ninos Dr Orlando Alassia, Santa Fe, Argentina. (author)
  • Berntson, Lillemor,1957-Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa(Swepub:uu)liber604 (author)
  • Bica, BlancaHosp Univ Clementino Fraga Filho, Rio De Janeiro, Brazil.;Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil. (author)
  • Brunner, JurgenMed Univ Innsbruck, Innsbruck, Austria. (author)
  • Costa-Reis, PatriciaUniv Lisbon, Hosp Santa Maria, Lisbon, Portugal. (author)
  • Eleftheriou, DespinaGreat Ormond St Hosp Children NHS Fdn Trust, London, England. (author)
  • Harel, LioraTel Aviv Univ, Fac Med, Schneider Childrens Med Ctr Israel Sackler, Petah Tiqwa, Israel. (author)
  • Horneff, GerdAsklepios Kln St Augustin, St Augustin, Germany. (author)
  • Kaiser, DanielaKinderspital, Luzerner Kantonsspital, Luzern, Switzerland. (author)
  • Kallinich, TilmannCharite, Berlin, Germany.;German Rheumatism Res Ctr Berlin, Berlin, Germany. (author)
  • Lazarevic, DraganaUniv Nis, Clin Ctr Nis, Nish, Serbia. (author)
  • Minden, KirstenCharite, Berlin, Germany.;German Rheumatism Res Ctr Berlin, Berlin, Germany. (author)
  • Nielsen, SusanRigshosp, Copenhagen, Denmark. (author)
  • Nuruzzaman, FarzanaStony Brook Childrens Hosp, Stony Brook, NY USA. (author)
  • Uziel, YosefTel Aviv Univ, Meir Med Ctr, Tel Aviv, Israel. (author)
  • Helmus, NicolaSchon Klin Hamburg Eilbek, Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany. (author)
  • Torok, Kathryn S.Univ Pittsburgh, Childrens Hosp Pittsburgh, Pittsburgh, PA 15224 USA. (author)
  • Schon Klin Hamburg Eilbek, Hamburg Ctr Pediat & Adolescent Rheumatol, Hamburg, Germany.German Rheumatism Res Ctr, Berlin, Germany. (creator_code:org_t)

Related titles

  • In:Arthritis care & research: John Wiley & Sons74:10, s. 1575-15842151-464X2151-4658

Internet link

Find in a library

To the university's database

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view