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Acute central nervo...
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Anastasopoulou, StavroulaKarolinska Institutet
(författare)
Acute central nervous system toxicity during treatment of pediatric acute lymphoblastic leukemia : phenotypes, risk factors and genotypes
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
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2022-03-31
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Ferrata Storti Foundation,2020
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-496029
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-496029URI
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https://doi.org/10.3324/haematol.2021.280016DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:151068615URI
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Språk:engelska
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Sammanfattning på:engelska
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Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Central nervous system (CNS) toxicity is common at diagnosis and during treatment of pediatric acute lymphoblastic leukemia (ALL). We studied CNS toxicity in 1,464 children aged 1.0-17.9 years, diagnosed with ALL and treated according to the Nordic Society of Pediatric Hematology and Oncology ALL2008 protocol. Genome-wide association studies, and a candidate single-nucleotide polymorphism (SNP; n=19) study were performed in 1,166 patients. Findings were validated in an independent Australian cohort of children with ALL (n=797) in whom two phenotypes were evaluated: diverse CNS toxicities (n=103) and methotrexate-related CNS toxicity (n=48). In total, 135/1,464 (9.2%) patients experienced CNS toxicity for a cumulative incidence of 8.7% (95% confidence interval: 7.31-10.20) at 12 months from diagnosis. Patients aged >= 10 years had a higher risk of CNS toxicity than had younger patients (16.3% vs. 7.4%; P < 0.001). The most common CNS toxicities were posterior reversible encephalopathy syndrome (n=52, 43 with seizures), sinus venous thrombosis (n=28, 9 with seizures), and isolated seizures (n=16). The most significant SNP identified by the genome-wide association studies did not reach genomic significance (lowest P-value: 1.11x10(-6)), but several were annotated in genes regulating neuronal functions. In candidate SNP analysis, ATXN1 rs68082256, related to epilepsy, was associated with seizures in patients < 10 years (P=0.01). ATXN1 rs68082256 was validated in the Australian cohort with diverse CNS toxicities (P=0.04). The role of ATXN1 as well as the novel SNP in neurotoxicity in pediatric ALL should be further explored.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Nielsen, Rikke LinnemannUniv Hosp, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark.;Tech Univ Denmark, Dept Hlth Technol, Lyngby, Denmark.;Novo Nordisk Res Ctr Oxford, Oxford, Oxfordshire, England.
(författare)
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Als-Nielsen, BodilUniv Hosp, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark.
(författare)
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Banerjee, JoannaUniv Helsinki, Helsinki Univ Hosp, Div Pediat Hematol & Oncol & Stem Cell Transplanta, Helsinki, Finland.
(författare)
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Eriksson, Mats A.Karolinska Institutet
(författare)
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Helenius, MarianneUniv Hosp, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark.;Tech Univ Denmark, Dept Hlth Technol, Lyngby, Denmark.
(författare)
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Heyman, Mats M.Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Childhood Canc Res Unit, Stockholm, Sweden.;Karolinska Inst, Dept Womens & Childrens Hlth, Neuropediat Unit, Stockholm, Sweden.
(författare)
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Johannsdottir, Inga MariaOslo Univ Hosp, Dept Pediat Hematol Oncol, Oslo, Norway.
(författare)
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Jonsson, Olafur GisliLandspitali Univ Hosp, Dept Pediat, Reykjavik, Iceland.
(författare)
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MacGregor, StuartQIMR Berghofer Med Res Inst, Brisbane, Qld, Australia.
(författare)
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Mateos, Marion K.Sydney Childrens Hosp Randwick, Kids Canc Ctr, Sydney, NSW, Australia.;Univ New South Wales, Sch Clin Med, Discipline Paediat & Child Hlth, Sydney, NSW, Australia.;Univ New South Wales, Childrens Canc Inst, Lowy Canc Res Ctr, Sydney, NSW, Australia.
(författare)
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Mayoh, ChelseaUniv New South Wales, Sch Clin Med, Discipline Paediat & Child Hlth, Sydney, NSW, Australia.;Univ New South Wales, Childrens Canc Inst, Lowy Canc Res Ctr, Sydney, NSW, Australia.
(författare)
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Mikkel, SirjeUniv Tartu, Dept Hematol & Oncol, Tartu, Estonia.
(författare)
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Myrberg, Ida HedKarolinska Institutet
(författare)
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Niinimäki, RiittaUniv Oulu, Oulu Univ Hosp, Dept Children & Adolescents, PEDEGO Res Unit, Oulu, Finland.
(författare)
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Schmiegelow, KjeldUniv Hosp, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark.;Univ Copenhagen, Inst Clin Med, Fac Med, Copenhagen, Denmark.
(författare)
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Taskinen, MerviUniv Helsinki, Helsinki Univ Hosp, Div Pediat Hematol & Oncol & Stem Cell Transplanta, Helsinki, Finland.
(författare)
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Vaitkeviciene, GodaVilnius Univ, Vilnius Univ Hosp Santaros Klin, Childrens Hosp, Vilnius, Lithuania.
(författare)
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Warnqvist, AnnaKarolinska Institutet
(författare)
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Wolthers, BenjaminUniv Hosp, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark.
(författare)
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Harila-Saari, Arja H.Uppsala universitet,Barnonkologisk och neurologisk forskning(Swepub:uu)arjha456
(författare)
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Ranta, SusannaKarolinska Institutet
(författare)
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Karolinska InstitutetUniv Hosp, Dept Pediat & Adolescent Med, Rigshosp, Copenhagen, Denmark.;Tech Univ Denmark, Dept Hlth Technol, Lyngby, Denmark.;Novo Nordisk Res Ctr Oxford, Oxford, Oxfordshire, England.
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Haematologica: Ferrata Storti Foundation107:10, s. 2318-23280390-60781592-8721
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Anastasopoulou, ...
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Nielsen, Rikke L ...
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Als-Nielsen, Bod ...
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Banerjee, Joanna
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Eriksson, Mats A ...
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Helenius, Marian ...
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visa fler...
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Heyman, Mats M.
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Johannsdottir, I ...
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Jonsson, Olafur ...
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MacGregor, Stuar ...
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Mateos, Marion K ...
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Mayoh, Chelsea
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Mikkel, Sirje
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Myrberg, Ida Hed
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Niinimäki, Riitt ...
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Schmiegelow, Kje ...
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Taskinen, Mervi
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Vaitkeviciene, G ...
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Warnqvist, Anna
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Wolthers, Benjam ...
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Harila-Saari, Ar ...
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Ranta, Susanna
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