Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: plea for improved follow-up

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Annebäck, MatildaUppsala universitet,Endokrinkirurgi (author)

Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort : plea for improved follow-up

Article/chapterEnglish2024

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Oxford University Press,2024
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LIBRIS-ID:oai:DiVA.org:uu-497029
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497029URI
https://doi.org/10.1093/bjs/znad366DOI

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Language:English
Summary in:English

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Title in the list of papers of Matilda Annebäck's thesis: Validating the risk of hypoparathyroidism after total thyroidectomy in a population-based cohort: a plea for improved follow-up
BackgroundA previous nationwide study from Sweden showed that the rate of permanent hypoparathyroidism is high and under-rated in the Swedish Quality Register. This retrospective population-based study aimed to validate the rate and diagnosis of permanent hypoparathyroidism found in the previous study. A secondary aim was to assess the relationship between the rate of low parathyroid hormone (PTH) levels within 24 h after surgery and the rate of permanent hypoparathyroidism.MethodsAll patients who underwent total thyroidectomy from 2005 to 2015 in a region of Sweden were included. Data were retrieved from local health records, the National Patient Registry, the Swedish Prescribed Drug Registry, and the Swedish Quality Register. A strict definition of permanent hypoparathyroidism was used, including biochemical data and attempts to stop the treatment.ResultsA total of 1636 patients were included. Altogether, 143 patients (8.7 per cent) developed permanent hypoparathyroidism. Of these, 102 (6.2 per cent) had definitive permanent hypoparathyroidism, whereas 41 (2.5 per cent) had possible permanent hypoparathyroidism, because attempts to stop the treatment were lacking (28) or patients were lost to follow-up (13). The agreement between the Swedish Quality Register and the chart review was 29.3 per cent. A proportion of 23.2 per cent with a PTH level below the reference value corresponded to a 6.7 per cent rate of permanent hypoparathyroidism.ConclusionThe risk of permanent hypoparathyroidism after total thyroidectomy is high. Some patients are overtreated because attempts to stop the treatment are lacking. Quality registers might underestimate the risk of permanent hypoparathyroidism. Approximately one-quarter of all patients with low PTH levels immediately after surgery developed permanent hypoparathyroidism.

Subject headings and genre

MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
Thyroidectomy
hypoparathyroidism
parathyroid hormone
quality register
Surgery
Kirurgi

Added entries (persons, corporate bodies, meetings, titles ...)

Osterman, Carolina (author)
Arlebrink, Jesper (author)
Mellerstedt, Simon (author)
Papathanasakis, Nicolas (author)
Wallin, Göran (author)
Hessman, Ola (author)
Annerbo, Maria (author)
Norlén, OlovUppsala universitet,Endokrinkirurgi(Swepub:uu)olono376 (author)
Uppsala universitetEndokrinkirurgi (creator_code:org_t)

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In:British Journal of Surgery: Oxford University Press111:10007-13231365-2168

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