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  • Ghosal, SumanEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)

Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • 2022-11-12
  • Springer Nature,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-497304
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-497304URI
  • https://doi.org/10.1007/s12020-022-03218-1DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • PurposeTo understand prognostic immune cell infiltration signatures in neuroendocrine neoplasms (NENs), particularly pheochromocytoma and paraganglioma (PCPG), we analyzed tumor transcriptomic data from The Cancer Genome Atlas (TCGA) and other published tumor transcriptomic data of NENs.MethodsWe used CIBERSORT to infer immune cell infiltrations from bulk tumor transcriptomic data from PCPGs, in comparison to gastroenteropancreatic neuroendocrine tumors (GEPNETs) and small cell lung carcinomas (SCLCs). PCPG immune signature was validated with NanoString immune panel in an independent cohort. Unsupervised clustering of the immune infiltration scores from CIBERSORT was used to find immune clusters. A prognostic immune score model for PCPGs and the other NENs were calculated as a linear combination of the estimated infiltration of activated CD8+/CD4+ T cells, activated NK cells, and M0 and M2 macrophages.ResultsIn PCPGs, we found five dominant immune clusters, associated with M2 macrophages, monocytes, activated NK cells, M0 macrophages and regulatory T cells, and CD8+/CD4+ T cells respectively. Non-metastatic tumors were associated with activated NK cells and metastatic tumors were associated with M0 macrophages and regulatory T cells. In GEPNETs and SCLCs, M0 macrophages and regulatory T cells were associated with unfavorable outcomes and features, such as metastasis and high-grade tumors. The prognostic immune score model for PCPGs and the NENs could predict non-aggressive and non-metastatic diseases. In PCPGs, the immune score was also an independent predictor of metastasis-free survival in a multivariate Cox regression analysis.ConclusionThe transcriptomic immune signature in PCPG correlates with clinical features like metastasis and prognosis.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • Vanova, Katerina HadravaEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Uher, OndrejEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic. (author)
  • Das, ShaoliNCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. (author)
  • Patel, MayankEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Meuter, LeahEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Huynh, Thanh-TrucEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Jha, AbhishekEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Talvacchio, SaraEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Knue, MarianneEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Prodanov, TamaraEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Zeiger, Martha A.NCI, Off Surg Scientists Programs, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. (author)
  • Nilubol, NarisNCI, Surg Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. (author)
  • Taieb, DavidAix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, Marseille, France.;Aix Marseille Univ, European Ctr Res Med Imaging, Marseille, France. (author)
  • Crona, JoakimUppsala universitet,Endokrin tumörbiologi,Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA(Swepub:uu)joacr310 (author)
  • Shankavaram, Uma T.NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA. (author)
  • Pacak, KarelEunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA. (author)
  • Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic. (creator_code:org_t)

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  • In:Endocrine: Springer Nature79:1, s. 171-1791355-008X1559-0100

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