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Immune signature of...
Immune signature of pheochromocytoma and paraganglioma in context of neuroendocrine neoplasms associated with prognosis
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- Ghosal, Suman (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Vanova, Katerina Hadrava (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Uher, Ondrej (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic.
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- Das, Shaoli (författare)
- NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
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- Patel, Mayank (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Meuter, Leah (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Huynh, Thanh-Truc (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Jha, Abhishek (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Talvacchio, Sara (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Knue, Marianne (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Prodanov, Tamara (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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- Zeiger, Martha A. (författare)
- NCI, Off Surg Scientists Programs, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
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- Nilubol, Naris (författare)
- NCI, Surg Oncol Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
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- Taieb, David (författare)
- Aix Marseille Univ, La Timone Univ Hosp, Dept Nucl Med, Marseille, France.;Aix Marseille Univ, European Ctr Res Med Imaging, Marseille, France.
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- Crona, Joakim (författare)
- Uppsala universitet,Endokrin tumörbiologi,Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA
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- Shankavaram, Uma T. (författare)
- NCI, Radiat Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.
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- Pacak, Karel (författare)
- Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.
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Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA Eunice Kennedy Shriver NICHHD, Sect Med Neuroendocrinol, NIH, Bethesda, MD 20892 USA.;Univ South Bohemia, Fac Sci, Dept Med Biol, Ceske Budejovice 37005, Czech Republic. (creator_code:org_t)
- 2022-11-12
- 2023
- Engelska.
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Ingår i: Endocrine. - : Springer Nature. - 1355-008X .- 1559-0100. ; 79:1, s. 171-179
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- PurposeTo understand prognostic immune cell infiltration signatures in neuroendocrine neoplasms (NENs), particularly pheochromocytoma and paraganglioma (PCPG), we analyzed tumor transcriptomic data from The Cancer Genome Atlas (TCGA) and other published tumor transcriptomic data of NENs.MethodsWe used CIBERSORT to infer immune cell infiltrations from bulk tumor transcriptomic data from PCPGs, in comparison to gastroenteropancreatic neuroendocrine tumors (GEPNETs) and small cell lung carcinomas (SCLCs). PCPG immune signature was validated with NanoString immune panel in an independent cohort. Unsupervised clustering of the immune infiltration scores from CIBERSORT was used to find immune clusters. A prognostic immune score model for PCPGs and the other NENs were calculated as a linear combination of the estimated infiltration of activated CD8+/CD4+ T cells, activated NK cells, and M0 and M2 macrophages.ResultsIn PCPGs, we found five dominant immune clusters, associated with M2 macrophages, monocytes, activated NK cells, M0 macrophages and regulatory T cells, and CD8+/CD4+ T cells respectively. Non-metastatic tumors were associated with activated NK cells and metastatic tumors were associated with M0 macrophages and regulatory T cells. In GEPNETs and SCLCs, M0 macrophages and regulatory T cells were associated with unfavorable outcomes and features, such as metastasis and high-grade tumors. The prognostic immune score model for PCPGs and the NENs could predict non-aggressive and non-metastatic diseases. In PCPGs, the immune score was also an independent predictor of metastasis-free survival in a multivariate Cox regression analysis.ConclusionThe transcriptomic immune signature in PCPG correlates with clinical features like metastasis and prognosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Immunologic signature
- Pheochromocytoma
- Paraganglioma
- Metastasis
- Biomarkers
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- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Ghosal, Suman
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Vanova, Katerina ...
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Uher, Ondrej
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Das, Shaoli
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Patel, Mayank
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Meuter, Leah
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Huynh, Thanh-Tru ...
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Jha, Abhishek
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Talvacchio, Sara
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Knue, Marianne
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Prodanov, Tamara
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Zeiger, Martha A ...
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Nilubol, Naris
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Taieb, David
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Crona, Joakim
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Shankavaram, Uma ...
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Pacak, Karel
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
- Artiklar i publikationen
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Endocrine
- Av lärosätet
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Uppsala universitet