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The paradigm of miR...
The paradigm of miRNA and siRNA influence in Oral-biome
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- Sinha, Adrija (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Bhattacharjee, Rahul (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Bhattacharya, Basudha (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Nandi, Aditya (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Shekhar, Ramya (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Jana, Ankit (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Saha, Koustav (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Kumar, Lamha (author)
- Indian Inst Sci Educ & Res, Sch Biol, Thiruvananthapuram, India.
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- Patro, Swadheena (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Dent Sci, Bhubaneswar, Odisha, India.
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- Panda, Pritam Kumar, PhD Student, 1991- (author)
- Uppsala universitet,Materialteori
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- Kaushik, Nagendra Kumar (author)
- Kwangwoon Univ, Plasma Biosci Res Ctr, Dept Elect & Biol Phys, Seoul 01897, South Korea.
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- Suar, Mrutyunjay (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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- Verma, Suresh K. (author)
- Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India.
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Kalinga Inst Ind Technol KIIT DU, KIIT Sch Biotechnol, Bhubaneswar, Odisha, India Indian Inst Sci Educ & Res, Sch Biol, Thiruvananthapuram, India. (creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
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In: Biomedicine and Pharmacotherapy. - : Elsevier. - 0753-3322 .- 1950-6007. ; 159
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Abstract
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- Short nucleotide sequences like miRNA and siRNA have attracted a lot of interest in Oral-biome investigations. miRNA is a small class of non-coding RNA that regulates gene expression to provide effective regulation of post-transcription. On contrary, siRNA is 21-25 nucleotide dsRNA impairing gene function post-transcriptionally through inhibition of mRNA for homologous dependent gene silencing. This review highlights the application of miRNA in oral biome including oral cancer, dental implants, periodontal diseases, gingival fibroblasts, oral submucous fibrosis, radiation-induced oral mucositis, dental Pulp, and oral lichenoid disease. Moreover, we have also discussed the application of siRNA against the aforementioned disease along with the impact of miRNA and siRNA to the various pathways and molecular effectors pertaining to the dental diseases. The influence of upregulation and downregulation of molecular effector post-treatment with miRNA and siRNA and their impact on the clinical setting has been elucidated. Thus, the mentioned details on application of miRNA and siRNA will provide a novel gateway to the scholars to not only mitigate the long-lasting issue in dentistry but also develop new theragnostic approaches.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- MicroRNA
- Small-interfering RNA
- Biomarker
- Therapeutic strategy
- Dental diseases
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- By the author/editor
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Sinha, Adrija
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Bhattacharjee, R ...
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Bhattacharya, Ba ...
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Nandi, Aditya
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Shekhar, Ramya
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Jana, Ankit
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Saha, Koustav
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Kumar, Lamha
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Patro, Swadheena
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Panda, Pritam Ku ...
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Kaushik, Nagendr ...
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Suar, Mrutyunjay
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Verma, Suresh K.
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Dentistry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Biomedicine and ...
- By the university
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Uppsala University