Sökning: WFRF:(Lampinen Maria) >
Genetic and shared ...
Genetic and shared environmental risk factors do not lead to eosinophil activation in healthy twins of IBD patients
-
- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.
-
- Lundström, Maria Ling (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
-
- Lampinen, Maria (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
-
visa fler...
-
- Schoultz, Ida, 1979- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Dept Med Sci, Örebro, Sweden.
-
- Bodin, Lennart, 1941- (författare)
- Karolinska Institutet,Örebro universitet,Handelshögskolan vid Örebro Universitet,Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden,Örebro Univ, Dept Stat, Örebro, Sweden.;Karolinska Inst, Inst Environm Med, Stockholm, Sweden.
-
- Carlson, Marie, 1957- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
-
visa färre...
-
(creator_code:org_t)
- 2020-08-20
- 2020
- Engelska.
-
Ingår i: Scandinavian Journal of Gastroenterology. - : Taylor & Francis. - 0036-5521 .- 1502-7708. ; 55:10, s. 1163-1170
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://www.tandfonl...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
http://kipublication...
-
visa färre...
Abstract
Ämnesord
Stäng
- Objective: To examine the role of eosinophils in the pre-diagnostic phase of inflammatory bowel disease (IBD), we studied the influence of genetic and shared environmental risk factors in a twin cohort of IBD.Material and methods: We analysed eosinophil derived neurotoxin (EDN) and eosinophil cationic protein (ECP) in faecal samples from twin pairs with Crohn's disease (n = 37) or ulcerative colitis (n = 21) and from external healthy controls (n = 44). Eosinophils stained with eosinophil peroxidase (EPO) were quantified in rectal biopsies. Ratios with 95% confidence intervals were calculated.Results: Twins with Crohn' disease displayed higher levels of EDN (Ratio = 2.98, 1.65-5.37) and ECP (Ratio 1.83, 1.24-2.70) than their healthy siblings. Levels did not differ between healthy twin-siblings and external controls (EDN, Ratio = 1.52, 0.79-2.94 and ECP, Ratio = 0.93, 0.56-1.54). Higher levels of EDN (Ratio = 2.43, 1.13-5.24) and ECP (Ratio = 1.53, 0.92-2.53) were observed among twins with ulcerative colitis vs their healthy siblings. Levels did not differ between healthy twin-siblings and external controls (EDN, Ratio = 1.08, 0.51-2.25 and ECP, Ratio = 1.29, 0.74-2.26). Using intra-class correlation coefficient (ICC), we found no agreement in levels of EDN or ECP in discordant pairs, except for ECP in monozygotic Crohn's disease pairs (ICC = 0.63). In contrast, agreement was observed in monozygotic pairs concordant for Crohn's disease (EDN, ICC = 0.67 and ECP, ICC = 0.66). The number of eosinophils in rectum was increased in twins with ulcerative colitis vs their healthy sibling (Ratio = 2.22, 1.50-3.27).Conclusions: Activation of eosinophils in IBD seems to be a consequence of inflammation rather than an effect of genetic and shared environmental risk factors alone.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
Nyckelord
- Inflammatory bowel disease
- eosinophils
- twins
- faecal markers
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas