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Plasma expansion an...
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Luther, TomasUppsala universitet,Anestesiologi och intensivvård
(author)
Plasma expansion and renal perfusion in critical COVID-19 with AKI: a prospective case control study
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LIBRIS-ID:oai:DiVA.org:uu-498343
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-498343URI
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Language:English
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Summary in:English
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Subject category:vet swepub-contenttype
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Subject category:ovr swepub-publicationtype
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Introduction: A decrease in renal perfusion during acute kidney injury (AKI) due to critical COVID-19 have previously been demonstrated. The objective of this study was to compare the effects of plasma expansion with a standardized fluid bolus on renal perfusion in critically ill patients with AKI compared to similar patients without AKI. Methods: A case control study design was used to investigate group differences before and after a standardized intervention. ICU-treated COVID-19 patients without underlying kidney disease were assigned to two groups based on KDIGO Creatinine criteria for AKI. Renal perfusion was assessed by magnetic resonance imaging using phase contrast and arterial spin labeling before and directly after plasma expansion with 7.5ml/kg Ringer’s Acetate (Baxter). Mean arterial pressure (MAP) was recorded before plasma infusion and compared with maximum value after. Data was analyzed with a mixed model repeated measures ANOVA for all kidneys using a random effect to account for research subjects. Results: Nine patients with AKI and eight without were included in the study. The hemodynamic response to plasma expansion was similar in both groups with increases in MAP by 18 mmHg (CI 8-28) and 20 mmHg (CI 10-31) in patients with and without AKI respectively. Total renal perfusion and cortical perfusion was not significantly changed by plasma expansion in either group. There were however there was a reduction of medullary perfusion in patients without AKI from 55 (CI 39-79) to 34 (CI 24-48) ml/min/100g (P = 0.0027).Conclusion: Plasma expansion with a standardized fluid bolus did not increase renal perfusion in critically ill patients with COVID-19.
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Eckerbom, Per,1974-Uppsala universitet,Radiologi(Swepub:uu)perec430
(author)
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Cox, EleanorSir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Not-tingham, Nottingham, UK and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK
(author)
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Lipcsey, MiklósUppsala universitet,Hedenstiernalaboratoriet(Swepub:uu)milip123
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Bülow Anderberg, SaraUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)sarbu486
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Hultström, Michael,1978-Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi(Swepub:uu)mihul498
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Weis, Jan,1956-Uppsala universitet,Radiologi,Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden(Swepub:uu)janweis
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Palm, Fredrik,1973-Uppsala universitet,Integrativ Fysiologi(Swepub:uu)fredpalm
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Francis, SusanSir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Not-tingham, Nottingham, UK and NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK
(author)
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Liss, Per,1960-Uppsala universitet,Radiologi,Institutionen för medicinsk cellbiologi(Swepub:uu)perliss
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Frithiof, RobertUppsala universitet,Hedenstiernalaboratoriet(Swepub:uu)robfr118
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Uppsala universitetAnestesiologi och intensivvård
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Luther, Tomas
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Eckerbom, Per, 1 ...
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Cox, Eleanor
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Lipcsey, Miklós
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Bülow Anderberg, ...
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Hultström, Micha ...
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Weis, Jan, 1956-
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Palm, Fredrik, 1 ...
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Francis, Susan
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Liss, Per, 1960-
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Frithiof, Robert
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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Uppsala University