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The population geno...
The population genomic legacy of the second plague pandemic
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- Gopalakrishnan, Shyam (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.
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- Ebenesersdottir, S. Sunna (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.;Univ Iceland, Sch Social Sci, Dept Anthropol, IS-102 Reykjavik, Iceland.
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- Lundström, Inge K. C. (författare)
- Karolinska Institutet
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visa fler...
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- Turner-Walker, Gordon (författare)
- Natl Yunlin Univ Sci & Technol, 123 Univ Rd,Sect 3, Touliu 64002, Yunlin, Taiwan.;Natl Museum Nat Sci, Dept Archaeol & Anthropol, 1 Guanqian Rd, Taichung 404023, Taiwan.
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- Moore, Kristjan H. S. (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.
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- Luisi, Pierre (författare)
- Univ Nacl Cordoba, Fac Filosofia & Humanidades, Cordoba, Argentina.;Inst Pasteur, Microbial Paleogen Unit, 25-28 Rue Dr Roux, F-75015 Paris, France.
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- Margaryan, Ashot (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.
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- Martin, Michael D. (författare)
- Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, N-7491 Trondheim, Norway.
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- Ellegaard, Martin Rene (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, N-7491 Trondheim, Norway.
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- Magnusson, Olafur P. (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.
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- Sigurosson, Asgeir (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.
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- Snorradottir, Steinunn (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.
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- Magnusdottir, Droplaug N. (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.
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- Laffoon, Jason E. (författare)
- Leiden Univ, Fac Archaeol, Dept Archaeol Sci, Leiden, Netherlands.
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- van Dorp, Lucy (författare)
- UCL, UCL Genet Inst, Dept Genet Evolut & Environm, Darwin Bldg,Gower St, London WC1E 6BT, England.
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- Liu, Xiaodong (författare)
- Univ Copenhagen, Dept Biol, Ole Maaloes Vej 5, DK-2200 Copenhagen, Denmark.
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- Moltke, Ida (författare)
- Univ Copenhagen, Dept Biol, Ole Maaloes Vej 5, DK-2200 Copenhagen, Denmark.
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- Avila-Arcos, Maria C. (författare)
- Univ Nacl Autonoma Mexico, Int Lab Human Genome Res, Lab Int Invest Genoma Humano LIIGH, 3001 Blvd Juriquilla, Queretaro 76230, Mexico.
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- Schraiber, Joshua G. (författare)
- Illumina Inc, Illumina Artificial Intelligence Lab, San Diego, CA USA.
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- Rasmussen, Simon (författare)
- Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, Blegdamsvej 3, DK-2200 Copenhagen, Denmark.
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- Juan, David (författare)
- Inst Evolutionary Biol UPF CSIC, PRBB, Dr Aiguader 88, Barcelona 08003, Spain.
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- Gelabert, Pere (författare)
- Inst Evolutionary Biol UPF CSIC, PRBB, Dr Aiguader 88, Barcelona 08003, Spain.;Univ Vienna, Dept Evolutionary Anthropol, Vienna, Austria.
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- de-Dios, Toni (författare)
- Inst Evolutionary Biol UPF CSIC, PRBB, Dr Aiguader 88, Barcelona 08003, Spain.
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- Fotakis, Anna K. (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.
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- Iraeta-Orbegozo, Miren (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.
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- Vågene, Åshild J. (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Max Planck Inst Sci Human Hist, Kahlaische Str 10, D-07745 Jena, Germany.;Univ Tubingen, Inst Archaeol Sci, Tubingen, Germany.
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- Denham, Sean Dexter (författare)
- Univ Stavanger, Museum Archaeol, Stavanger, Norway.
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- Christophersen, Axel (författare)
- Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, N-7491 Trondheim, Norway.
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- Stenøien, Hans K. (författare)
- Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, N-7491 Trondheim, Norway.
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- Vieira, Filipe G. (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.
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- Liu, Shanlin (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;BGI Shenzhen, China Natl GeneBank, Shenzhen 518083, Peoples R China.
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- Günther, Torsten (författare)
- Uppsala universitet,Människans evolution
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- Kivisild, Toomas (författare)
- Katholieke Univ Leuven, Herestr 49, B-3000 Leuven, Belgium.;Univ Tartu, Inst Genom, Riia 23b, EE-51010 Tartu, Estonia.
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- Moseng, Ole Georg (författare)
- Univ South Eastern Norway, Dept Business Hist & Social Sci, Notodden, Norway.
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- Skar, Birgitte (författare)
- Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, N-7491 Trondheim, Norway.
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- Cheung, Christina (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Univ Paris Diderot, EA Ecoanthropol UMR 7206, Museum Natl Hist Nat, CNRS, Paris, France.
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- Sandoval-Velasco, Marcela (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.
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- Wales, Nathan (författare)
- Univ York, Dept Archaeol, Kings Manor & Principals House,Exhibit Sq, York YO1 7EP, N Yorkshire, England.
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- Schroeder, Hannes (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.
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- Campos, Paula F. (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental, Terminal Cruzeiros Porto Leixoes, Ave Gen Norton Matos, Matosinhos, Portugal.
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- Guomundsdottir, Valdis B. (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.;Univ Iceland, Sch Social Sci, Dept Anthropol, IS-102 Reykjavik, Iceland.
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- Sicheritz-Ponten, Thomas (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Asian Inst Med Sci & Technol AIMST, Fac Appl Sci, Ctr Excellence Om Driven Computat Biodiscovery CO, Bedong 08100, Kedah, Malaysia.
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- Peterson, Bent (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Asian Inst Med Sci & Technol AIMST, Fac Appl Sci, Ctr Excellence Om Driven Computat Biodiscovery CO, Bedong 08100, Kedah, Malaysia.
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- Halgunset, Jostein (författare)
- St Olavs Hosp HF, Biobank1, Trondheim, Norway.
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- Gilbert, Edmund (författare)
- RCSI, Sch Pharm & Biomol Sci, Dublin, Ireland.;RCSI, FutureNeuro SFI Res Ctr, Dublin, Ireland.
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- Cavalleri, Gianpiero L. (författare)
- RCSI, Sch Pharm & Biomol Sci, Dublin, Ireland.;RCSI, FutureNeuro SFI Res Ctr, Dublin, Ireland.
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- Hovig, Eivind (författare)
- Oslo Univ Hosp, Inst Canc Res, Dept Tumor Biol, Oslo, Norway.;Univ Oslo, Ctr Bioinformat, Dept Informat, Oslo, Norway.
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- Kockum, Ingrid (författare)
- Karolinska Inst, Ctr Mol Med, Dept Clin Neurosci, Neuroimmunol Unit, Stockholm, Sweden.
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- Olsson, Tomas (författare)
- Karolinska Institutet
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- Alfredsson, Lars (författare)
- Karolinska Institutet
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- Hansen, Thomas F. (författare)
- Copenhagen Mental Hlth Serv, Inst Biol Psychiat, Copenhagen, Denmark.;Copenhagen Univ Hosp, Danish Headache Ctr, Dept Neurol, DK-2600 Glostrup, Denmark.
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- Werge, Thomas (författare)
- Copenhagen Mental Hlth Serv, Inst Biol Psychiat, Copenhagen, Denmark.;Univ Copenhagen, Dept Clin Med, Copenhagen, Denmark.;Lundbeck Fdn Initiat Integrat Psychiat Res, IPSYCH, Copenhagen, Denmark.;Lundbeck Fdn Ctr Geogenet, Globe Inst, Oster Voldgade 5-7, DK-1350 Copenhagen K, Denmark.
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- Willerslev, Eske (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Univ Cambridge, Dept Zool, Cambridge CB2 3EJ, England.
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- Balloux, Francois (författare)
- UCL, UCL Genet Inst, Dept Genet Evolut & Environm, Darwin Bldg,Gower St, London WC1E 6BT, England.
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- Marques-Bonet, Tomas (författare)
- Inst Evolutionary Biol UPF CSIC, PRBB, Dr Aiguader 88, Barcelona 08003, Spain.;Catalan Inst Res & Adv Studies ICREA, Passeig Lluis Companys 23, Barcelona 08010, Spain.;Barcelona Inst Sci & Technol BIST, Ctr Genom Regulat CRG, CNAG CRG, Baldiri & Reixac 4, Barcelona 08028, Spain.;Univ Autonoma Barcelona, Inst Catala Paleontol Miquel Crusafont, Edifici ICTA ICP,C Columnes S-N, E-08193 Barcelona, Spain.
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- Lalueza-Fox, Carles (författare)
- Inst Evolutionary Biol UPF CSIC, PRBB, Dr Aiguader 88, Barcelona 08003, Spain.;Museu Ciencies Nat Barcelona, Barcelona 08019, Spain.
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- Nielsen, Rasmus (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Univ Calif Berkeley, Dept Integrat Biol, 3060 Valley Life Sci Bldg 3140, Berkeley, CA 94720 USA.
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- Stefansson, Kari (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.;Univ Iceland, Fac Med, Reykjavik, Iceland.
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- Holgason, Agnar (författare)
- AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.;Univ Iceland, Sch Social Sci, Dept Anthropol, IS-102 Reykjavik, Iceland.
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- Gilbert, M. Thomas P. (författare)
- Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark.;Norwegian Univ Sci & Technol NTNU, NTNU Univ Museum, N-7491 Trondheim, Norway.
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Univ Copenhagen, GLOBE Inst, Fac Hlth & Med Sci, Oster Farimagsgade 5A, DK-1353 Copenhagen, Denmark AMGEN Inc, deCODE Genet, Sturlugata 8, IS-102 Reykjavik, Iceland.;Univ Iceland, Sch Social Sci, Dept Anthropol, IS-102 Reykjavik, Iceland. (creator_code:org_t)
- Elsevier, 2022
- 2022
- Engelska.
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Ingår i: Current Biology. - : Elsevier. - 0960-9822 .- 1879-0445. ; 32:21, s. 4743-4751.e6
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Human populations have been shaped by catastrophes that may have left long-lasting signatures in their genomes. One notable example is the second plague pandemic that entered Europe in ca. 1,347 CE and repeatedly returned for over 300 years, with typical village and town mortality estimated at 10%–40%.1 It is assumed that this high mortality affected the gene pools of these populations. First, local population crashes reduced genetic diversity. Second, a change in frequency is expected for sequence variants that may have affected survival or susceptibility to the etiologic agent (Yersinia pestis).2 Third, mass mortality might alter the local gene pools through its impact on subsequent migration patterns. We explored these factors using the Norwegian city of Trondheim as a model, by sequencing 54 genomes spanning three time periods: (1) prior to the plague striking Trondheim in 1,349 CE, (2) the 17th–19th century, and (3) the present. We find that the pandemic period shaped the gene pool by reducing long distance immigration, in particular from the British Isles, and inducing a bottleneck that reduced genetic diversity. Although we also observe an excess of large FST values at multiple loci in the genome, these are shaped by reference biases introduced by mapping our relatively low genome coverage degraded DNA to the reference genome. This implies that attempts to detect selection using ancient DNA (aDNA) datasets that vary by read length and depth of sequencing coverage may be particularly challenging until methods have been developed to account for the impact of differential reference bias on test statistics.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
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Gopalakrishnan, ...
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Ebenesersdottir, ...
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Lundström, Inge ...
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Turner-Walker, G ...
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Moore, Kristjan ...
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Luisi, Pierre
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Margaryan, Ashot
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Martin, Michael ...
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Ellegaard, Marti ...
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Magnusson, Olafu ...
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Sigurosson, Asge ...
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Snorradottir, St ...
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Magnusdottir, Dr ...
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Laffoon, Jason E ...
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van Dorp, Lucy
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Liu, Xiaodong
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Moltke, Ida
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Avila-Arcos, Mar ...
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Schraiber, Joshu ...
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Rasmussen, Simon
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Juan, David
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Gelabert, Pere
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de-Dios, Toni
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Fotakis, Anna K.
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Iraeta-Orbegozo, ...
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Vågene, Åshild J ...
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Denham, Sean Dex ...
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Christophersen, ...
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Stenøien, Hans K ...
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Vieira, Filipe G ...
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Liu, Shanlin
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Günther, Torsten
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Kivisild, Toomas
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Moseng, Ole Geor ...
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Skar, Birgitte
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Cheung, Christin ...
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Sandoval-Velasco ...
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Wales, Nathan
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Schroeder, Hanne ...
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Campos, Paula F.
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Guomundsdottir, ...
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Sicheritz-Ponten ...
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Peterson, Bent
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Halgunset, Joste ...
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Gilbert, Edmund
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Cavalleri, Gianp ...
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Hovig, Eivind
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Kockum, Ingrid
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Olsson, Tomas
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Alfredsson, Lars
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Hansen, Thomas F ...
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Werge, Thomas
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Willerslev, Eske
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Balloux, Francoi ...
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Marques-Bonet, T ...
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Lalueza-Fox, Car ...
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Nielsen, Rasmus
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Stefansson, Kari
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Holgason, Agnar
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Gilbert, M. Thom ...
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